GB1435863A - Aminoquinoline derivatives - Google Patents

Aminoquinoline derivatives

Info

Publication number
GB1435863A
GB1435863A GB2590774A GB2590774A GB1435863A GB 1435863 A GB1435863 A GB 1435863A GB 2590774 A GB2590774 A GB 2590774A GB 2590774 A GB2590774 A GB 2590774A GB 1435863 A GB1435863 A GB 1435863A
Authority
GB
United Kingdom
Prior art keywords
substituted
hydrogen
prepared
alkyl
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2590774A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Publication of GB1435863A publication Critical patent/GB1435863A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

1435863 1 - [p - (4 - Quinolyl)amino benzoyl] - 4 - phenyl piperazines UPJOHN CO 11 June 1974 [15 June 1973] 25907/74 Heading C2C [Also in Division A5] Novel compounds of the Formula I and pharmaceutically acceptable acid addition salts thereof wherein R 1 and R 2 are each hydrogen, halogen, alkyl, alkoxy or trihalomethyl and R 3 is hydrogen or alkyl, where the alkyl radicals in the above radicals have 1 to 4 carbonatoms may be prepared by condensing a 4-chloroquinoline II with a compound of the Formula III The intermediates of the Formula III wherein R 3 is hydrogen are prepared by reaction of an R 2 substituted aniline with diethanolamine to form an R 2 substituted 1-phenyl piperazine followed by condensation with p-nitrobenzoylchloride to yield 1-(p-nitrobenzoyl)-4-(R 2 substituted phenyl)piperazine and finally reduction of the nitro group to an amino group. Various R 1 substituted-4-chloroquinolines disclosed are prepared by known methods.
GB2590774A 1973-06-15 1974-06-11 Aminoquinoline derivatives Expired GB1435863A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US37034273A 1973-06-15 1973-06-15

Publications (1)

Publication Number Publication Date
GB1435863A true GB1435863A (en) 1976-05-19

Family

ID=23459233

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2590774A Expired GB1435863A (en) 1973-06-15 1974-06-11 Aminoquinoline derivatives

Country Status (7)

Country Link
JP (1) JPS5019759A (en)
BE (1) BE816356A (en)
DE (1) DE2428193C2 (en)
FR (1) FR2233062B1 (en)
GB (1) GB1435863A (en)
NL (1) NL7407962A (en)
ZA (1) ZA743269B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4140775A (en) * 1978-05-05 1979-02-20 The Upjohn Company Piperazino methyl phenyl aminoquinolines
US4167567A (en) * 1978-05-05 1979-09-11 The Upjohn Company Antihypertensive 4-aminoquinolines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE754587A (en) * 1969-08-08 1971-02-08 Upjohn Co NEW P- (TRIHALOMETHYLQUINOLYLAMINO) BENZAMIDES AND THEIR PREPARATION PROCESS
BE754586A (en) * 1969-08-08 1971-02-08 Upjohn Co PHARMACEUTICAL PREPARATIONS BASED ON P- (4-QUINOLYLAMINO) BENZAMIDE AND THEIR USE

Also Published As

Publication number Publication date
JPS5019759A (en) 1975-03-01
DE2428193A1 (en) 1975-01-09
FR2233062A1 (en) 1975-01-10
BE816356A (en) 1974-12-16
DE2428193C2 (en) 1985-07-11
NL7407962A (en) 1974-12-17
ZA743269B (en) 1975-05-28
FR2233062B1 (en) 1978-07-28

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee