GB1438600A - Aminoquinoline derivatives - Google Patents
Aminoquinoline derivativesInfo
- Publication number
- GB1438600A GB1438600A GB2590574A GB2590574A GB1438600A GB 1438600 A GB1438600 A GB 1438600A GB 2590574 A GB2590574 A GB 2590574A GB 2590574 A GB2590574 A GB 2590574A GB 1438600 A GB1438600 A GB 1438600A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- prepared
- piperazine
- trihalomethyl
- june
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
- C07D215/42—Nitrogen atoms attached in position 4
- C07D215/44—Nitrogen atoms attached in position 4 with aryl radicals attached to said nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
- A61K31/515—Barbituric acids; Derivatives thereof, e.g. sodium pentobarbital
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/74—Synthetic polymeric materials
- A61K31/765—Polymers containing oxygen
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Quinoline Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1438600 1 - [p - (4 - Quinolylamino)- benzoyl]piperazine-4-oxides UPJOHN CO 11 June 1974 [15 June 1973] 25905/74 Heading C2C [Also in Division A5] Novel compounds of the Formula I wherein R 1 is hydrogen, halogen, alkyl, alkoxy or trihalomethyl, R 2 is alkyl, benzyl, phenyl or phenyl monosubstituted with halogen, alkyl, alkoxy or trihalomethyl, R 3 is hydrogen or alkyl where alkyl groups above have 1 to 4 carbon atoms, hydrates and pharmaceutically acceptable acid additon salts thereof may be prepared by oxidation to form the 4-oxide group on the piperazine ring, optionally followed by salt and/or hydrate formation. The intermediates of the Formula II may be prepared by condensation of an appropriate 4-chloroquinoline with an appropriate 1-p-amino benzoyl)piperazine. Various 4-chloroquinolines disclosed are prepared by known methods.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US37034173A | 1973-06-15 | 1973-06-15 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1438600A true GB1438600A (en) | 1976-06-09 |
Family
ID=23459230
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2590574A Expired GB1438600A (en) | 1973-06-15 | 1974-06-11 | Aminoquinoline derivatives |
Country Status (7)
Country | Link |
---|---|
JP (1) | JPS5019762A (en) |
BE (1) | BE816354A (en) |
DE (1) | DE2428190A1 (en) |
FR (1) | FR2233061B1 (en) |
GB (1) | GB1438600A (en) |
NL (1) | NL7407961A (en) |
ZA (1) | ZA743271B (en) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6132575U (en) * | 1984-07-30 | 1986-02-27 | 東北三國工業株式会社 | plunger type pump |
JPS61186772U (en) * | 1985-05-15 | 1986-11-21 | ||
JPS623971U (en) * | 1985-06-24 | 1987-01-10 | ||
JPH0220788U (en) * | 1988-07-26 | 1990-02-13 |
-
1974
- 1974-05-21 ZA ZA00743271A patent/ZA743271B/en unknown
- 1974-05-31 JP JP49061034A patent/JPS5019762A/ja active Pending
- 1974-06-11 DE DE19742428190 patent/DE2428190A1/en not_active Withdrawn
- 1974-06-11 GB GB2590574A patent/GB1438600A/en not_active Expired
- 1974-06-14 BE BE145439A patent/BE816354A/en not_active IP Right Cessation
- 1974-06-14 NL NL7407961A patent/NL7407961A/xx not_active Application Discontinuation
- 1974-06-14 FR FR7420748A patent/FR2233061B1/fr not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NL7407961A (en) | 1974-12-17 |
JPS5019762A (en) | 1975-03-01 |
DE2428190A1 (en) | 1975-01-09 |
ZA743271B (en) | 1975-05-28 |
BE816354A (en) | 1974-12-16 |
FR2233061B1 (en) | 1978-07-28 |
FR2233061A1 (en) | 1975-01-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed | ||
PCNP | Patent ceased through non-payment of renewal fee |