GB1428493A - Heterocyclic amides processes for their preparation and pharma ceutical compositions containing them - Google Patents
Heterocyclic amides processes for their preparation and pharma ceutical compositions containing themInfo
- Publication number
- GB1428493A GB1428493A GB2084273A GB2084273A GB1428493A GB 1428493 A GB1428493 A GB 1428493A GB 2084273 A GB2084273 A GB 2084273A GB 2084273 A GB2084273 A GB 2084273A GB 1428493 A GB1428493 A GB 1428493A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- reacting
- compounds
- acid
- pyrimidinecarboxamides
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- -1 Heterocyclic amides Chemical class 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- 239000002253 acid Substances 0.000 abstract 4
- 150000001875 compounds Chemical class 0.000 abstract 4
- 239000004215 Carbon black (E152) Substances 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229930195733 hydrocarbon Natural products 0.000 abstract 2
- 235000005152 nicotinamide Nutrition 0.000 abstract 2
- 150000005480 nicotinamides Chemical class 0.000 abstract 2
- FUXJMHXHGDAHPD-UHFFFAOYSA-N pyrimidine-2-carboxamide Chemical class NC(=O)C1=NC=CC=N1 FUXJMHXHGDAHPD-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 2
- KPIVDNYJNOPGBE-UHFFFAOYSA-N 2-aminonicotinic acid Chemical class NC1=NC=CC=C1C(O)=O KPIVDNYJNOPGBE-UHFFFAOYSA-N 0.000 abstract 1
- NUILQFNJMVDDJG-UHFFFAOYSA-N 4-aminopyrimidine-2-carboxylic acid Chemical class NC1=CC=NC(C(O)=O)=N1 NUILQFNJMVDDJG-UHFFFAOYSA-N 0.000 abstract 1
- QJZZQGUDXLIHNT-UHFFFAOYSA-N 6-acetamidopyridine-3-carbonyl chloride Chemical compound CC(=O)NC1=CC=C(C(Cl)=O)C=N1 QJZZQGUDXLIHNT-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 150000001408 amides Chemical class 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000001262 anti-secretory effect Effects 0.000 abstract 1
- 230000000767 anti-ulcer Effects 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 230000000850 deacetylating effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 230000005176 gastrointestinal motility Effects 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/81—Amides; Imides
- C07D213/82—Amides; Imides in position 3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Priority Applications (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2084273A GB1428493A (en) | 1973-05-02 | 1973-05-02 | Heterocyclic amides processes for their preparation and pharma ceutical compositions containing them |
| DE19742419535 DE2419535C3 (de) | 1973-05-02 | 1974-04-23 | 6-Aminonicotinsäureamide, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
| CH577274A CH590234A5 (enExample) | 1973-05-02 | 1974-04-26 | |
| CA198,244A CA1025865A (fr) | 1973-05-02 | 1974-04-26 | Procedes de preparation de nouvelles amides heterocycliques |
| SE7405743A SE401502B (sv) | 1973-05-02 | 1974-04-29 | Sett att frasmtella nya substituerade nikotinsyraamider |
| FR7414933A FR2227866B1 (enExample) | 1973-05-02 | 1974-04-30 | |
| SU7402020311A SU576927A3 (ru) | 1973-05-02 | 1974-04-30 | Способ получени гетероциклических амидов или их солей |
| JP49049238A JPS523937B2 (enExample) | 1973-05-02 | 1974-05-01 | |
| US05/465,931 US3970661A (en) | 1973-05-02 | 1974-05-01 | 2-Amino, 5-carbamoyl pyridine compounds |
| AU68427/74A AU483565B2 (en) | 1973-05-02 | 1974-05-01 | Heterocyclic amides, processes for their preparation and pharmaceutical compositions containing them |
| US05/615,452 US3970663A (en) | 1973-05-02 | 1975-09-22 | Certain amino-nicotinamide derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB2084273A GB1428493A (en) | 1973-05-02 | 1973-05-02 | Heterocyclic amides processes for their preparation and pharma ceutical compositions containing them |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1428493A true GB1428493A (en) | 1976-03-17 |
Family
ID=10152644
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2084273A Expired GB1428493A (en) | 1973-05-02 | 1973-05-02 | Heterocyclic amides processes for their preparation and pharma ceutical compositions containing them |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3970661A (enExample) |
| JP (1) | JPS523937B2 (enExample) |
| CA (1) | CA1025865A (enExample) |
| CH (1) | CH590234A5 (enExample) |
| FR (1) | FR2227866B1 (enExample) |
| GB (1) | GB1428493A (enExample) |
| SE (1) | SE401502B (enExample) |
| SU (1) | SU576927A3 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2663026B1 (fr) * | 1990-06-07 | 1992-08-07 | Synthelabo | Derives de [(1-arylpyrrolidin-2-yl) methyl] piperazine, leur preparation et leur application en therapeutique. |
| FR2684374B1 (fr) * | 1991-12-02 | 1995-05-19 | Synthelabo | Derives substitues de 1-[(1-arylpyrrolidin-2-yl)methyl]piperazine, leur preparation et leur application en therapeutique. |
| US7176310B1 (en) | 2002-04-09 | 2007-02-13 | Ucb Sa | Pyrimidinecarboxamide derivatives and their use as anti-inflammatory agents |
| FR2928070A1 (fr) * | 2008-02-27 | 2009-09-04 | Sumitomo Chemical Co | Composition agricole, utilisation d'un compose pour sa production et procede pour matriser ou prevenir les maladies des plantes. |
| US20170247326A1 (en) * | 2014-09-10 | 2017-08-31 | Epizyme, Inc. | Substituted Pyrrolidine Carboxamide Compounds |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3105072A (en) * | 1963-09-24 | Preparation thereof |
-
1973
- 1973-05-02 GB GB2084273A patent/GB1428493A/en not_active Expired
-
1974
- 1974-04-26 CH CH577274A patent/CH590234A5/xx not_active IP Right Cessation
- 1974-04-26 CA CA198,244A patent/CA1025865A/fr not_active Expired
- 1974-04-29 SE SE7405743A patent/SE401502B/xx unknown
- 1974-04-30 SU SU7402020311A patent/SU576927A3/ru active
- 1974-04-30 FR FR7414933A patent/FR2227866B1/fr not_active Expired
- 1974-05-01 US US05/465,931 patent/US3970661A/en not_active Expired - Lifetime
- 1974-05-01 JP JP49049238A patent/JPS523937B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2227866B1 (enExample) | 1978-06-30 |
| SE401502B (sv) | 1978-05-16 |
| JPS523937B2 (enExample) | 1977-01-31 |
| US3970661A (en) | 1976-07-20 |
| SU576927A3 (ru) | 1977-10-15 |
| JPS5018472A (enExample) | 1975-02-26 |
| FR2227866A1 (enExample) | 1974-11-29 |
| CA1025865A (fr) | 1978-02-07 |
| DE2419535A1 (de) | 1974-12-12 |
| DE2419535B2 (de) | 1977-01-13 |
| CH590234A5 (enExample) | 1977-07-29 |
| AU6842774A (en) | 1975-11-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |