GB1425961A - Prostanoic acid derivatives - Google Patents
Prostanoic acid derivativesInfo
- Publication number
- GB1425961A GB1425961A GB1422273A GB1422273A GB1425961A GB 1425961 A GB1425961 A GB 1425961A GB 1422273 A GB1422273 A GB 1422273A GB 1422273 A GB1422273 A GB 1422273A GB 1425961 A GB1425961 A GB 1425961A
- Authority
- GB
- United Kingdom
- Prior art keywords
- compounds
- etherified
- formula
- prostaglandins
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- WGJJROVFWIXTPA-OALUTQOASA-N prostanoic acid Chemical class CCCCCCCC[C@H]1CCC[C@@H]1CCCCCCC(O)=O WGJJROVFWIXTPA-OALUTQOASA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 9
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 5
- 229940094443 oxytocics prostaglandins Drugs 0.000 abstract 4
- 150000003180 prostaglandins Chemical class 0.000 abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004043 oxo group Chemical group O=* 0.000 abstract 2
- 101000837626 Homo sapiens Thyroid hormone receptor alpha Proteins 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 102100028702 Thyroid hormone receptor alpha Human genes 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 239000003153 chemical reaction reagent Substances 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 125000001188 haloalkyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 230000001590 oxidative effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/93—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems condensed with a ring other than six-membered
- C07D307/935—Not further condensed cyclopenta [b] furans or hydrogenated cyclopenta [b] furans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0016—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing only hydroxy, etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0025—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing keto groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
- C07C405/0008—Analogues having the carboxyl group in the side-chains replaced by other functional groups
- C07C405/0033—Analogues having the carboxyl group in the side-chains replaced by other functional groups containing sulfur
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
- C07D309/12—Oxygen atoms only hydrogen atoms and one oxygen atom directly attached to ring carbon atoms, e.g. tetrahydropyranyl ethers
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT2306372 | 1972-04-13 | ||
| IT2366272 | 1972-04-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1425961A true GB1425961A (en) | 1976-02-25 |
Family
ID=26328323
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2731375A Expired GB1425962A (en) | 1972-04-13 | 1973-03-23 | Lactols and lactones |
| GB1422273A Expired GB1425961A (en) | 1972-04-13 | 1973-03-23 | Prostanoic acid derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2731375A Expired GB1425962A (en) | 1972-04-13 | 1973-03-23 | Lactols and lactones |
Country Status (18)
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO150117C (no) * | 1974-09-17 | 1984-08-22 | Erba Farmitalia | Analogifremgangsmaate for fremstilling av terapeutisk aktive prostaglandinderivater |
| DK155317C (da) * | 1974-09-25 | 1989-08-14 | Erba Carlo Spa | 13,14-dehydro-prostaglandin-f2alfa-derivater til anvendelse i midler med abortfremkaldende aktivitet |
| IT1053781B (it) * | 1974-09-25 | 1981-10-10 | Erba C S P A Ora Farmitalia | Omega nor cicloalcil 13.14 deidro prostaglandine |
| US4169145A (en) * | 1974-09-25 | 1979-09-25 | Carlo Erba S.P.A. | ω-Nor-cycloalkyl-13,14-dehydro-prostaglandins |
| AU501803B2 (en) * | 1975-03-21 | 1979-06-28 | Farmitalia Carlo Erba S.P.A. | Fluoro-prostaglandins |
| US4029681A (en) * | 1976-02-13 | 1977-06-14 | The Upjohn Company | 13,14-Didehydro-PG analogs |
| US4207422A (en) * | 1976-07-26 | 1980-06-10 | The Upjohn Company | 2-Decarboxy-2-hydroxymethyl-3,7-inter-m-phenylene-13,14-didehydro-PGA, PGD, and PGE compounds |
| US4058564A (en) * | 1976-07-26 | 1977-11-15 | The Upjohn Company | Aliphatic 2-decarboxy-2-hydroxymethyl-13,14-didehydro-PG compounds |
| US4140721A (en) * | 1976-07-26 | 1979-02-20 | The Upjohn Company | 2-Decarboxy-2-hydroxymethyl-13,14-didehydro-17-phenyl-PGA, PGD and PGE compounds |
| DE2655004C3 (de) * | 1976-12-02 | 1980-06-19 | Schering Ag, 1000 Berlin Und 4619 Bergkamen | Verfahren zur Herstellung von bicyclischen Laktonen |
| JPS5662969A (en) * | 1979-10-26 | 1981-05-29 | Mitsubishi Gas Chem Co Inc | Preventing method for corrosion of metal surface |
| US4288632A (en) | 1980-04-03 | 1981-09-08 | American Cyanamid Company | 1-Hydroxymethyl-11,16-dihydroxy-prosten-1-ol derivatives |
| US4310700A (en) | 1980-04-03 | 1982-01-12 | American Cyanamid Company | 1-Hydroxylmethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives |
| US4291174A (en) * | 1980-04-03 | 1981-09-22 | American Cyanamid Company | 1-Hydroxymethyl-15-hydroxy-prosten-1-ol derivatives |
| US4288630A (en) | 1980-04-03 | 1981-09-08 | American Cyanamid Company | 1-Hydroxymethyl-11,15-dihydroxy-prosten-1-ol-derivatives |
| US4291175A (en) * | 1980-04-03 | 1981-09-22 | American Cyanamid Company | 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives |
| US4288629A (en) | 1980-04-03 | 1981-09-08 | American Cyanamid Company | 1-Hydroxymethyl-11-deoxy-15-hydroxy-prosten-1-ol-derivatives |
| US4288633A (en) | 1980-04-03 | 1981-09-08 | American Cyanamid Company | 1-Hydroxymethyl-11-deoxy-16-hydroxy-prosten-1-ol-derivatives |
| CH656877A5 (de) * | 1981-11-27 | 1986-07-31 | Erba Farmitalia | Optisch aktive oder racemische prostaglandinderivate. |
| CZ306366B6 (cs) * | 2015-06-03 | 2016-12-21 | Univerzita Pardubice | Způsob přípravy intermediátu přípravy prostaglandinového derivátu alfaprostolu |
| CN110256385A (zh) * | 2019-07-10 | 2019-09-20 | 上海玉函化工有限公司 | 一种前列腺素类药物中间体的制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3728382A (en) * | 1970-05-04 | 1973-04-17 | Upjohn Co | 15-methyl and 15-ethyl prostaglandin analogs |
| US3711515A (en) * | 1970-11-27 | 1973-01-16 | Upjohn Co | Tricyclic lactone alkene or alkenyne |
-
1973
- 1973-03-23 GB GB2731375A patent/GB1425962A/en not_active Expired
- 1973-03-23 GB GB1422273A patent/GB1425961A/en not_active Expired
- 1973-03-30 US US05/346,249 patent/US3935254A/en not_active Expired - Lifetime
- 1973-04-10 AT AT315173A patent/AT351177B/de not_active IP Right Cessation
- 1973-04-10 DK DK193573A patent/DK147468C/da not_active IP Right Cessation
- 1973-04-12 CS CS2593A patent/CS174195B2/cs unknown
- 1973-04-12 CA CA168,551A patent/CA1016166A/en not_active Expired
- 1973-04-12 SU SU731919945A patent/SU656510A3/ru active
- 1973-04-12 NO NO1537/73A patent/NO143575C/no unknown
- 1973-04-12 SE SE7305181A patent/SE406762B/xx unknown
- 1973-04-13 HU HUEA128A patent/HU169182B/hu unknown
- 1973-04-13 CH CH538273A patent/CH591441A5/xx not_active IP Right Cessation
- 1973-04-13 NL NLAANVRAGE7305222,A patent/NL182400C/xx not_active IP Right Cessation
- 1973-04-13 JP JP4204973A patent/JPS577148B2/ja not_active Expired
- 1973-04-13 DE DE2318785A patent/DE2318785C2/de not_active Expired
- 1973-04-13 FR FR7313538A patent/FR2187334B1/fr not_active Expired
- 1973-04-13 CH CH424376A patent/CH599149A5/xx not_active IP Right Cessation
- 1973-05-08 IL IL42223A patent/IL42223A/en unknown
-
1975
- 1975-02-05 US US05/547,247 patent/US4035392A/en not_active Expired - Lifetime
- 1975-08-26 FR FR7526314A patent/FR2279744A1/fr active Granted
- 1975-11-13 US US05/631,656 patent/US4035414A/en not_active Expired - Lifetime
- 1975-11-13 US US05/631,655 patent/US4021477A/en not_active Expired - Lifetime
-
1977
- 1977-01-20 HK HK32/77A patent/HK3277A/xx unknown
- 1977-12-30 MY MY132/77A patent/MY7700132A/xx unknown
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |