GB1413892A - 2-pyrimidinyl-thio-acetic acids and their derivatives - Google Patents
2-pyrimidinyl-thio-acetic acids and their derivativesInfo
- Publication number
- GB1413892A GB1413892A GB1506873A GB1506873A GB1413892A GB 1413892 A GB1413892 A GB 1413892A GB 1506873 A GB1506873 A GB 1506873A GB 1506873 A GB1506873 A GB 1506873A GB 1413892 A GB1413892 A GB 1413892A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkoxy
- alkyl
- hydrogen
- halogen
- alkoxyphenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KCLKMYQLVMTDRL-UHFFFAOYSA-N 2-pyrimidin-2-ylethanethioic s-acid Chemical class OC(=S)CC1=NC=CC=N1 KCLKMYQLVMTDRL-UHFFFAOYSA-N 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 10
- 125000003545 alkoxy group Chemical group 0.000 abstract 7
- 125000000217 alkyl group Chemical group 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical class 0.000 abstract 5
- 125000005036 alkoxyphenyl group Chemical group 0.000 abstract 4
- -1 2 - Pyrimidinylthio Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 abstract 1
- 230000002484 anti-cholesterolemic effect Effects 0.000 abstract 1
- VHKHLJZIHLSVLW-UHFFFAOYSA-N ethyl 2-(4-chloropyrimidin-2-yl)sulfanylacetate Chemical compound CCOC(=O)CSC1=NC=CC(Cl)=N1 VHKHLJZIHLSVLW-UHFFFAOYSA-N 0.000 abstract 1
- YDXPGTAZHLTZPW-UHFFFAOYSA-N ethyl 2-[(4-oxo-6-phenyl-1h-pyrimidin-2-yl)sulfanyl]acetate Chemical compound N1C(SCC(=O)OCC)=NC(=O)C=C1C1=CC=CC=C1 YDXPGTAZHLTZPW-UHFFFAOYSA-N 0.000 abstract 1
- 125000003106 haloaryl group Chemical group 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/06—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/38—One sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/56—One oxygen atom and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/60—Three or more oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C23—COATING METALLIC MATERIAL; COATING MATERIAL WITH METALLIC MATERIAL; CHEMICAL SURFACE TREATMENT; DIFFUSION TREATMENT OF METALLIC MATERIAL; COATING BY VACUUM EVAPORATION, BY SPUTTERING, BY ION IMPLANTATION OR BY CHEMICAL VAPOUR DEPOSITION, IN GENERAL; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL
- C23F—NON-MECHANICAL REMOVAL OF METALLIC MATERIAL FROM SURFACE; INHIBITING CORROSION OF METALLIC MATERIAL OR INCRUSTATION IN GENERAL; MULTI-STEP PROCESSES FOR SURFACE TREATMENT OF METALLIC MATERIAL INVOLVING AT LEAST ONE PROCESS PROVIDED FOR IN CLASS C23 AND AT LEAST ONE PROCESS COVERED BY SUBCLASS C21D OR C22F OR CLASS C25
- C23F11/00—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent
- C23F11/08—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids
- C23F11/10—Inhibiting corrosion of metallic material by applying inhibitors to the surface in danger of corrosion or adding them to the corrosive agent in other liquids using organic inhibitors
- C23F11/14—Nitrogen-containing compounds
- C23F11/149—Heterocyclic compounds containing nitrogen as hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US00240266A US3814761A (en) | 1972-03-31 | 1972-03-31 | (2-pyrimidinylthio)alkanoic acids,esters,amides and hydrazides |
| US38443973A | 1973-08-01 | 1973-08-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1413892A true GB1413892A (en) | 1975-11-12 |
Family
ID=26933281
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1506873A Expired GB1413892A (en) | 1972-03-31 | 1973-03-29 | 2-pyrimidinyl-thio-acetic acids and their derivatives |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US3814761A (https=) |
| JP (1) | JPS4913186A (https=) |
| BE (1) | BE797622A (https=) |
| CA (1) | CA967571A (https=) |
| CH (1) | CH590243A5 (https=) |
| DE (1) | DE2314160A1 (https=) |
| FR (1) | FR2182917B1 (https=) |
| GB (1) | GB1413892A (https=) |
| NL (1) | NL7304481A (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0411706A1 (en) * | 1989-07-31 | 1991-02-06 | Shell Internationale Researchmaatschappij B.V. | Sulphonamide herbicides |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3901887A (en) * | 1972-03-31 | 1975-08-26 | American Home Prod | (2-pyrimidinylthio) alkanoic acids, esters, amides and hydrazides |
| US3974162A (en) * | 1972-12-21 | 1976-08-10 | American Home Products Corporation | 4-Pyrimidinylthioacetic acid derivatives |
| US3920648A (en) * | 1973-06-08 | 1975-11-18 | Sandoz Ag | Hypolipidemic 5-phenyl-2-oxyacetic and 2-mercaptoacetic acids and esters |
| US3950339A (en) * | 1974-10-15 | 1976-04-13 | American Home Products Corporation | Substituted-2-(pyrimidinylthio)acetamidoximes and acetonitriles |
| US4188484A (en) * | 1976-03-17 | 1980-02-12 | L'Instituto Farmaceutico S.p.A. | (2-Pyrimidinyl-thio)-alkanoic acid amides and their preparation |
| JPS5642260Y2 (https=) * | 1977-07-29 | 1981-10-02 | ||
| JPS5642259Y2 (https=) * | 1977-07-29 | 1981-10-02 | ||
| JPS55111319A (en) * | 1979-02-13 | 1980-08-27 | Electric Power Dev Co Ltd | Method of transportation for high viscosity fluid |
| JPS5661234A (en) * | 1979-10-25 | 1981-05-26 | Electric Power Dev Co Ltd | Conversion of granular substance to slurry and device therefor |
| IT1211096B (it) * | 1981-08-20 | 1989-09-29 | Lpb Ist Farm | Pirimidine e s.triazinici adattivita' ipolipidemizzante. |
| US4404302A (en) * | 1982-05-27 | 1983-09-13 | Ferro Corporation | Acylated hindered hexahydropyrimidines and their use as light stabilizing agents |
| US4612375A (en) * | 1983-05-02 | 1986-09-16 | Riker Laboratories, Inc. | Substituted 4-hydrazino-pyrimides as intermediates for triazolo [4,3-c]pyrimidines |
| US4629769A (en) * | 1985-09-30 | 1986-12-16 | Texaco Inc. | 4,4,6-trimethylhexahydropyrimidine as an epoxy curing agent |
| EP0347811B1 (en) * | 1988-06-20 | 1994-03-30 | Kumiai Chemical Industry Co., Ltd. | Alkanoic acid derivatives and herbicidal compositions |
| US20030191144A1 (en) * | 2001-06-12 | 2003-10-09 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
| WO2002100836A2 (en) * | 2001-06-12 | 2002-12-19 | Active Pass Pharmaceuticals, Inc. | Compounds, compositions and methods for modulating beta-amyloid production |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2530570A (en) * | 1950-11-21 | Pyrimidylmercapto-carboxylic acids | ||
| US2621182A (en) * | 1952-12-09 | Office | ||
| US3943134A (en) * | 1973-11-08 | 1976-03-09 | Sankyo Company Limited | Process for preparing acetonin |
| US3904625A (en) * | 1974-04-08 | 1975-09-09 | Petrolite Corp | Use of ion exchange resins in preparing tetrahydropyrimidines |
| US4001232A (en) * | 1974-08-17 | 1977-01-04 | Bayer Aktiengesellschaft | Process for preparing 1-substituted 2-methyl-tetrahydropyrimidines |
-
1972
- 1972-03-31 US US00240266A patent/US3814761A/en not_active Expired - Lifetime
-
1973
- 1973-03-22 DE DE19732314160 patent/DE2314160A1/de active Pending
- 1973-03-29 GB GB1506873A patent/GB1413892A/en not_active Expired
- 1973-03-30 FR FR7311602A patent/FR2182917B1/fr not_active Expired
- 1973-03-30 CH CH461873A patent/CH590243A5/xx not_active IP Right Cessation
- 1973-03-30 CA CA167,592A patent/CA967571A/en not_active Expired
- 1973-03-30 BE BE129525A patent/BE797622A/xx unknown
- 1973-03-30 NL NL7304481A patent/NL7304481A/xx not_active Application Discontinuation
- 1973-03-31 JP JP48037364A patent/JPS4913186A/ja active Pending
-
1977
- 1977-06-01 US US05/802,347 patent/US4146714A/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0411706A1 (en) * | 1989-07-31 | 1991-02-06 | Shell Internationale Researchmaatschappij B.V. | Sulphonamide herbicides |
| TR24550A (tr) * | 1989-07-31 | 1991-11-01 | Shell Int Research | Suelfonamid herbisidleri. |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4913186A (https=) | 1974-02-05 |
| DE2314160A1 (de) | 1973-10-18 |
| NL7304481A (https=) | 1973-10-02 |
| US4146714A (en) | 1979-03-27 |
| AU5310073A (en) | 1974-09-12 |
| US3814761A (en) | 1974-06-04 |
| BE797622A (fr) | 1973-10-01 |
| FR2182917A1 (https=) | 1973-12-14 |
| CA967571A (en) | 1975-05-13 |
| CH590243A5 (https=) | 1977-07-29 |
| FR2182917B1 (https=) | 1976-12-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |