GB1409280A - Coating materials for enteric medicaments - Google Patents

Coating materials for enteric medicaments

Info

Publication number
GB1409280A
GB1409280A GB4675772A GB4675772A GB1409280A GB 1409280 A GB1409280 A GB 1409280A GB 4675772 A GB4675772 A GB 4675772A GB 4675772 A GB4675772 A GB 4675772A GB 1409280 A GB1409280 A GB 1409280A
Authority
GB
United Kingdom
Prior art keywords
hydrogen
copolymer
alkyl
carboxylic acid
partial
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4675772A
Inventor
M Sharabash
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of GB1409280A publication Critical patent/GB1409280A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/284Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A61K9/2846Poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4891Coated capsules; Multilayered drug free capsule shells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08FMACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F8/00Chemical modification by after-treatment

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Medicinal Preparation (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1409280 Partial alkylene glycol ether esters of copolymers ELI LILLY & CO 11 Oct 1972 [12 Oct 1971] 46757/72 Heading C3P [Also in Division A5] A partial alkylene glycol ether ester of a copolymer having as monomers a C 1 -C 4 alkyl acrylate and an unsaturated polybasic carboxylic acid anhydride, a molecular weight of at least 14,000 and comprising structural units of formula or wherein R 1 is C 1 -C 4 alkyl, R 2 is hydrogen or methyl, R 3 and R 4 are hydrogen or the moiety wherein R 5 is hydrogen or diethyl and R 6 is C 1 -C 4 alkyl, with the proviso that from 10 to 50% of the R 3 and R 4 groups are other than hydrogen, q is a whole number from 1 to 4 and x and y are whole numbers from 1 to 5 may be prepared by copolymerizing a C 1 -C 4 alkyl acrylate and an unsaturated polybasic carboxylic acid anhydride in a mole ratio of from 1 : 5 to 5 : 1 and esterifying the copolymer thus obtained with a C 1 -C 4 alkyl ether of a C 2 or C 3 alkylene glycol having from 1 to 4 alkylene units such that from 10 to 50% of the available carboxylic acid moieties of the copolymer are esterified with one ether. A coating composition for entenic medicaments comprises a mixture of such an ester and a partial C 1 -C 4 alkanol ester of the same copolymer.
GB4675772A 1971-10-12 1972-10-11 Coating materials for enteric medicaments Expired GB1409280A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US18859171A 1971-10-12 1971-10-12

Publications (1)

Publication Number Publication Date
GB1409280A true GB1409280A (en) 1975-10-08

Family

ID=22693788

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4675772A Expired GB1409280A (en) 1971-10-12 1972-10-11 Coating materials for enteric medicaments

Country Status (25)

Country Link
JP (1) JPS4847590A (en)
AR (1) AR194852A1 (en)
AT (2) AT316139B (en)
AU (1) AU473557B2 (en)
BE (1) BE789919A (en)
BR (1) BR7207119D0 (en)
CA (1) CA1004799A (en)
CH (1) CH575967A5 (en)
DD (2) DD103248A5 (en)
DE (1) DE2250028A1 (en)
DK (1) DK138503B (en)
ES (1) ES407563A1 (en)
FR (1) FR2157847B1 (en)
GB (1) GB1409280A (en)
HU (1) HU165803B (en)
IE (1) IE36731B1 (en)
IL (1) IL40520A (en)
IT (1) IT990509B (en)
NL (1) NL7213765A (en)
PH (1) PH13179A (en)
PL (2) PL102291B1 (en)
RO (1) RO62797A (en)
SE (2) SE400979B (en)
YU (1) YU34904B (en)
ZA (1) ZA727066B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2164339A (en) * 1984-09-11 1986-03-19 Ciba Geigy Ag Polymaleic anhydride derivatives
GB2340521A (en) * 1998-08-15 2000-02-23 Sofitech Nv Shale-stabilizing additives

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1115596B (en) * 1978-03-13 1986-02-03 Bayer Italia Spa METHOD FOR THE PREPARATION OF GASTORESISTANT AND ENTERO-SOLUBLE MICROGRANULES OF PHARMACEUTICAL SUBSTANCES, IN PARTICULAR OF PROTEIN SUBSTANCES AND MICROGRANULES PREPARED WITH THE METHOD
AU4428000A (en) * 1999-05-14 2000-12-05 Coraltis Ltd. Pulse-delivery oral compositions
CN113855643B (en) * 2021-11-10 2022-11-11 葵花药业集团佳木斯鹿灵制药有限公司 Mesalazine sustained release preparation for colon-specific drug release and preparation process thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE575343A (en) * 1955-09-09
US3369003A (en) * 1962-03-06 1968-02-13 Sinclair Research Inc Polymers of tertiary-alkoxyalkyl esters
NL289626A (en) * 1962-03-06 1900-01-01
US3387061A (en) * 1966-05-04 1968-06-04 Union Carbide Corp Chemical reaction product of polycarboxylic acid and a polymeric polyether
GB1213030A (en) * 1968-08-16 1970-11-18 Daicel Ltd Process for producing a graft copolymer
JPS4931557A (en) * 1972-07-22 1974-03-22

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2164339A (en) * 1984-09-11 1986-03-19 Ciba Geigy Ag Polymaleic anhydride derivatives
US4734204A (en) * 1984-09-11 1988-03-29 Ciba-Geigy Corporation Polymaleic anhydride derivatives
GB2340521A (en) * 1998-08-15 2000-02-23 Sofitech Nv Shale-stabilizing additives
GB2340521B (en) * 1998-08-15 2000-09-13 Sofitech Nv Shale-stabilizing additives

Also Published As

Publication number Publication date
AU473557B2 (en) 1976-06-24
AT316139B (en) 1974-06-25
YU255672A (en) 1979-10-31
FR2157847A1 (en) 1973-06-08
DK138503C (en) 1979-02-26
FR2157847B1 (en) 1975-10-31
DK138503B (en) 1978-09-18
PL76176B1 (en) 1975-02-28
ES407563A1 (en) 1976-02-01
CH575967A5 (en) 1976-05-31
ATA858173A (en) 1975-07-15
CA1004799A (en) 1977-02-01
IL40520A (en) 1975-12-31
YU34904B (en) 1980-04-30
IT990509B (en) 1975-07-10
ZA727066B (en) 1974-05-29
SE400979B (en) 1978-04-17
SE411123B (en) 1979-12-03
IL40520A0 (en) 1972-12-29
AR194852A1 (en) 1973-08-24
AU4745172A (en) 1974-04-11
HU165803B (en) 1974-11-28
PL102291B1 (en) 1979-03-31
DD103248A5 (en) 1974-01-12
DD109508A5 (en) 1974-11-12
RO62797A (en) 1977-10-15
PH13179A (en) 1980-01-08
BE789919A (en) 1973-04-11
NL7213765A (en) 1973-04-16
IE36731L (en) 1973-04-12
SE7604731L (en) 1976-04-23
JPS4847590A (en) 1973-07-06
IE36731B1 (en) 1977-02-02
BR7207119D0 (en) 1973-07-19
AT329185B (en) 1976-04-26
DE2250028A1 (en) 1973-04-19

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee