GB1399139A - Alkyl esters of polyene antibiotics - Google Patents
Alkyl esters of polyene antibioticsInfo
- Publication number
- GB1399139A GB1399139A GB3449772A GB3449772A GB1399139A GB 1399139 A GB1399139 A GB 1399139A GB 3449772 A GB3449772 A GB 3449772A GB 3449772 A GB3449772 A GB 3449772A GB 1399139 A GB1399139 A GB 1399139A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl ester
- polyene antibiotics
- alkyl esters
- esters
- amphotericin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002459 polyene antibiotic agent Substances 0.000 title abstract 4
- 125000005907 alkyl ester group Chemical group 0.000 title abstract 2
- -1 candicidin methyl ester Chemical class 0.000 abstract 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- APKFDSVGJQXUKY-KKGHZKTASA-N Amphotericin-B Natural products O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1C=CC=CC=CC=CC=CC=CC=C[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-KKGHZKTASA-N 0.000 abstract 1
- NCXMLFZGDNKEPB-UHFFFAOYSA-N Pimaricin Natural products OC1C(N)C(O)C(C)OC1OC1C=CC=CC=CC=CCC(C)OC(=O)C=CC2OC2CC(O)CC(O)(CC(O)C2C(O)=O)OC2C1 NCXMLFZGDNKEPB-UHFFFAOYSA-N 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 abstract 1
- UAZIZEMIKKIBCA-TYVGYKFWSA-N amphotericin B methyl ester Chemical compound O([C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@]2(O)C[C@H](O)[C@H]([C@H](C1)O2)C(=O)OC)[C@@H]1O[C@H](C)[C@@H](O)[C@H](N)[C@@H]1O UAZIZEMIKKIBCA-TYVGYKFWSA-N 0.000 abstract 1
- 229960003942 amphotericin b Drugs 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 229960004348 candicidin Drugs 0.000 abstract 1
- 230000003197 catalytic effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 150000004702 methyl esters Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 229960003255 natamycin Drugs 0.000 abstract 1
- 229960000988 nystatin Drugs 0.000 abstract 1
- 150000007530 organic bases Chemical class 0.000 abstract 1
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 abstract 1
- DCKVNWZUADLDEH-UHFFFAOYSA-N sec-butyl acetate Chemical compound CCC(C)OC(C)=O DCKVNWZUADLDEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Compounds Of Unknown Constitution (AREA)
- Saccharide Compounds (AREA)
Priority Applications (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3449772A GB1399139A (en) | 1972-07-24 | 1972-07-24 | Alkyl esters of polyene antibiotics |
| DE19732336397 DE2336397A1 (de) | 1972-07-24 | 1973-07-17 | Alkylester von polyen-antibiotika |
| BE133622A BE802512A (fr) | 1972-07-24 | 1973-07-18 | Esters alkyliques de polyenes antibiotiques |
| NL7309990A NL7309990A (enExample) | 1972-07-24 | 1973-07-18 | |
| FR7326525A FR2193575B1 (enExample) | 1972-07-24 | 1973-07-19 | |
| CA176,925A CA998996A (en) | 1972-07-24 | 1973-07-20 | Alkyl esters of polyene antibiotics |
| US05/381,563 US3936526A (en) | 1972-07-24 | 1973-07-23 | Alkyl esters of polyene antibiotics |
| JP8393773A JPS5310562B2 (enExample) | 1972-07-24 | 1973-07-24 | |
| US05/630,888 US4038382A (en) | 1972-07-24 | 1975-11-11 | Alkyl esters of polyene antibiotics |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3449772A GB1399139A (en) | 1972-07-24 | 1972-07-24 | Alkyl esters of polyene antibiotics |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1399139A true GB1399139A (en) | 1975-06-25 |
Family
ID=10366391
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3449772A Expired GB1399139A (en) | 1972-07-24 | 1972-07-24 | Alkyl esters of polyene antibiotics |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US3936526A (enExample) |
| JP (1) | JPS5310562B2 (enExample) |
| BE (1) | BE802512A (enExample) |
| CA (1) | CA998996A (enExample) |
| DE (1) | DE2336397A1 (enExample) |
| FR (1) | FR2193575B1 (enExample) |
| GB (1) | GB1399139A (enExample) |
| NL (1) | NL7309990A (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA795508B (en) | 1978-10-23 | 1981-05-27 | Schering Corp | Derivatives of polyene macrolide antibiotics containing an amino sugar moiety, process for the preparation thereof, and pharmaceutical compositions containing them |
| JPS5967457U (ja) * | 1982-10-29 | 1984-05-07 | 大日本印刷株式会社 | 取手 |
| US5981721A (en) * | 1997-10-23 | 1999-11-09 | Karykion Corporation | Polyene macrolide schiff bases, their alkyl esters and processes for preparing polyene macrolide alkyl ester salts thereof |
| DE10117216A1 (de) * | 2001-04-06 | 2002-10-17 | Asa Spezialenzyme Gmbh | Herstellung von Pimaricin und Pimaricinderivaten sowie dessen Einsatz im Pflanzenschutz |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3945993A (en) * | 1971-06-07 | 1976-03-23 | Rutgers Research And Educational Foundation | Derivatives of polyene macrolide antibiotics |
-
1972
- 1972-07-24 GB GB3449772A patent/GB1399139A/en not_active Expired
-
1973
- 1973-07-17 DE DE19732336397 patent/DE2336397A1/de not_active Ceased
- 1973-07-18 NL NL7309990A patent/NL7309990A/xx unknown
- 1973-07-18 BE BE133622A patent/BE802512A/xx not_active IP Right Cessation
- 1973-07-19 FR FR7326525A patent/FR2193575B1/fr not_active Expired
- 1973-07-20 CA CA176,925A patent/CA998996A/en not_active Expired
- 1973-07-23 US US05/381,563 patent/US3936526A/en not_active Expired - Lifetime
- 1973-07-24 JP JP8393773A patent/JPS5310562B2/ja not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2193575A1 (enExample) | 1974-02-22 |
| CA998996A (en) | 1976-10-26 |
| JPS49124002A (enExample) | 1974-11-27 |
| JPS5310562B2 (enExample) | 1978-04-14 |
| FR2193575B1 (enExample) | 1977-04-15 |
| DE2336397A1 (de) | 1974-02-14 |
| BE802512A (fr) | 1973-11-16 |
| NL7309990A (enExample) | 1974-01-28 |
| US3936526A (en) | 1976-02-03 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19930709 |