ES8206622A1 - Un procedimiento para la preparacion de una nueva macrolida - Google Patents

Un procedimiento para la preparacion de una nueva macrolida

Info

Publication number
ES8206622A1
ES8206622A1 ES503957A ES503957A ES8206622A1 ES 8206622 A1 ES8206622 A1 ES 8206622A1 ES 503957 A ES503957 A ES 503957A ES 503957 A ES503957 A ES 503957A ES 8206622 A1 ES8206622 A1 ES 8206622A1
Authority
ES
Spain
Prior art keywords
preparation
macrolide antibiotics
compositions containing
veterinary compositions
mycarosyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503957A
Other languages
English (en)
Other versions
ES503957A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES8206622A1 publication Critical patent/ES8206622A1/es
Publication of ES503957A0 publication Critical patent/ES503957A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/44—Preparation of O-glycosides, e.g. glucosides
    • C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
    • C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/465—Streptomyces
    • C12R2001/54—Streptomyces fradiae

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Saccharide Compounds (AREA)

Abstract

PROCEDIMIENTO DE OBTENCION DE MACROLIDAS. CONSISTE EN CULTIVAR UNA CEPA DE STREPTOMYCES GRADIAE BAJO CONDICIONES AEROBIAS SUMERGIDAS HASTA QUE SE HA PRODUCIDO UNA CANTIDAD SUSTANCIAL DE ACTIVIDAD ANTIBIOTICA. SI SE DESEA PRODUCIR EL COMPUESTO DE FORMULA GENERAL (I), DONDE Y ES HIDROXILO, EL CULTIVO DEBE REALIZARSE EMPLEANDO CONDICIONES DEBILMENTE ACIDAS, Q ES CHO O CH2OH, Y ES HIDROXILO O UN GRUPO MIRALOXILOXI.
ES503957A 1980-07-24 1981-07-14 Un procedimiento para la preparacion de una nueva macrolida Granted ES503957A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8024211 1980-07-24

Publications (2)

Publication Number Publication Date
ES8206622A1 true ES8206622A1 (es) 1982-05-16
ES503957A0 ES503957A0 (es) 1982-05-16

Family

ID=10514997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503957A Granted ES503957A0 (es) 1980-07-24 1981-07-14 Un procedimiento para la preparacion de una nueva macrolida

Country Status (23)

Country Link
EP (1) EP0045157B1 (es)
JP (1) JPS5750998A (es)
KR (1) KR840001193B1 (es)
AR (1) AR227325A1 (es)
AU (1) AU7286281A (es)
CA (1) CA1174994A (es)
CS (1) CS228512B2 (es)
DD (1) DD202452A5 (es)
DE (1) DE3163204D1 (es)
DK (1) DK313081A (es)
ES (1) ES503957A0 (es)
FI (1) FI812209L (es)
GB (1) GB2080798B (es)
GR (1) GR74509B (es)
HU (1) HU189519B (es)
IE (1) IE51619B1 (es)
IL (1) IL63312A (es)
PH (1) PH18089A (es)
PL (1) PL232190A1 (es)
PT (1) PT73370B (es)
RO (1) RO81671B (es)
YU (1) YU173981A (es)
ZA (1) ZA814789B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4411892A (en) * 1982-05-03 1983-10-25 Pfizer Inc. Tylosin macrolide antibiotics from streptomyces
US4443436A (en) * 1982-09-13 1984-04-17 Eli Lilly And Company C-20-Modified macrolide derivatives of the macrolide antibiotics tylosin, desmycosin, macrocin, and lactenocin
US4820694A (en) * 1986-09-29 1989-04-11 Eli Lilly And Company Modifications of 3-O-demethylmycinose in macrocin and lactenocin

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4201843A (en) * 1975-08-01 1980-05-06 Sanraku Ocean Co., Ltd. Process for manufacturing tylosin derivatives

Also Published As

Publication number Publication date
DD202452A5 (de) 1983-09-14
IE51619B1 (en) 1987-01-21
JPS5750998A (en) 1982-03-25
PH18089A (en) 1985-03-20
YU173981A (en) 1983-09-30
EP0045157B1 (en) 1984-04-18
PT73370B (en) 1982-08-09
IL63312A0 (en) 1981-10-30
AR227325A1 (es) 1982-10-15
RO81671B (ro) 1983-04-30
ZA814789B (en) 1983-02-23
RO81671A (ro) 1983-04-29
DK313081A (da) 1982-01-25
AU7286281A (en) 1982-01-28
IE811581L (en) 1982-01-24
FI812209L (fi) 1982-01-25
PT73370A (en) 1981-08-01
GB2080798B (en) 1984-07-25
IL63312A (en) 1985-04-30
PL232190A1 (es) 1982-03-29
CS228512B2 (en) 1984-05-14
EP0045157A1 (en) 1982-02-03
KR840001193B1 (ko) 1984-08-18
HU189519B (en) 1986-07-28
GR74509B (es) 1984-06-29
DE3163204D1 (en) 1984-05-24
CA1174994A (en) 1984-09-25
GB2080798A (en) 1982-02-10
ES503957A0 (es) 1982-05-16

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