ES8203963A1 - Un procedimiento para la preparacion de una macrolida - Google Patents
Un procedimiento para la preparacion de una macrolidaInfo
- Publication number
- ES8203963A1 ES8203963A1 ES502981A ES502981A ES8203963A1 ES 8203963 A1 ES8203963 A1 ES 8203963A1 ES 502981 A ES502981 A ES 502981A ES 502981 A ES502981 A ES 502981A ES 8203963 A1 ES8203963 A1 ES 8203963A1
- Authority
- ES
- Spain
- Prior art keywords
- macrolide
- ch2oh
- formula
- macrolide antibiotics
- antibiotics
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/08—Oxygen as only ring hetero atoms containing a hetero ring of at least seven ring members, e.g. zearalenone, macrolide aglycons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/20—Bacteria; Culture media therefor
- C12N1/205—Bacterial isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/44—Preparation of O-glycosides, e.g. glucosides
- C12P19/60—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin
- C12P19/62—Preparation of O-glycosides, e.g. glucosides having an oxygen of the saccharide radical directly bound to a non-saccharide heterocyclic ring or a condensed ring system containing a non-saccharide heterocyclic ring, e.g. coumermycin, novobiocin the hetero ring having eight or more ring members and only oxygen as ring hetero atoms, e.g. erythromycin, spiramycin, nystatin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
- C12R2001/465—Streptomyces
- C12R2001/54—Streptomyces fradiae
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Processing Of Solid Wastes (AREA)
- Compounds Of Unknown Constitution (AREA)
Abstract
PROCEDIMIENTO PARA LA OBTENCION DE UNA MACROLIDA, ASI COMO DE SUS ESTERES Y SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA Q ES CH2OH O CHO. CONSISTE EN EL CULTIVO DE STREPTOMYCES FRADIAE NRRL 12171 EN CONDICIONES AEROBIAS SUMERGIDAS HASTA OBTENER UNA CANTIDAD SUSTANCIAL DE ACTIVIDAD ANTIBIOTICA PARA QUE SE PRODUZCA LA MACROLIDA. TAMBIEN SE PUEDE REDUCIR QUIMICAMENTE LA 23-DESMICINOSILTILOSINA PARA OBTENER LA MACROLIDA DE FORMULA (I), EN LA QUE Q ES CH2OH. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS COMO ANTIBIOTICOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/156,855 US4321362A (en) | 1980-06-12 | 1980-06-12 | De(mycinosyloxy)tylosin and process for its production |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8203963A1 true ES8203963A1 (es) | 1982-04-16 |
ES502981A0 ES502981A0 (es) | 1982-04-16 |
Family
ID=22561375
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES502981A Granted ES502981A0 (es) | 1980-06-12 | 1981-06-11 | Un procedimiento para la preparacion de una macrolida |
Country Status (24)
Country | Link |
---|---|
EP (1) | EP0042694B1 (es) |
JP (1) | JPS5731698A (es) |
KR (1) | KR840001957B1 (es) |
AT (1) | ATE6468T1 (es) |
AU (1) | AU544358B2 (es) |
CA (1) | CA1172190A (es) |
CS (1) | CS225842B2 (es) |
DD (1) | DD159645A5 (es) |
DE (1) | DE3162501D1 (es) |
DK (1) | DK255581A (es) |
ES (1) | ES502981A0 (es) |
FI (1) | FI811827L (es) |
GB (1) | GB2077730B (es) |
GR (1) | GR75276B (es) |
HU (1) | HU189979B (es) |
IE (1) | IE51613B1 (es) |
IL (1) | IL63076A (es) |
NZ (1) | NZ197360A (es) |
PH (1) | PH15924A (es) |
PT (1) | PT73164B (es) |
RO (1) | RO81017A (es) |
SU (1) | SU1134120A3 (es) |
YU (1) | YU144281A (es) |
ZA (1) | ZA813578B (es) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4423148A (en) * | 1982-07-02 | 1983-12-27 | Eli Lilly And Company | Process for producing 20-dihydro-20-deoxy-23-de(mycinosyloxy)tylosin |
US4435388A (en) | 1982-06-10 | 1984-03-06 | Schering Corporation | Tylosin 20-imino-20-deoxo-4"-acyl derivatives, pharmaceutical compositions and method of use |
JPS58219197A (ja) * | 1982-06-15 | 1983-12-20 | Sanraku Inc | マクロライド系抗生物質の誘導体 |
US4436729A (en) * | 1982-06-30 | 1984-03-13 | Schering Corporation | 23-Demycinosyltylosin compounds, pharmaceutical compositions and method of use |
US4452784A (en) * | 1982-07-19 | 1984-06-05 | Eli Lilly And Company | C-23-Modified derivatives of DMT |
IL71032A0 (en) * | 1983-02-28 | 1984-05-31 | Lilly Co Eli | C-20 and c-23-modified macrolide derivatives |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1428452A (fr) * | 1958-10-29 | 1966-02-18 | Lilly Co Eli | Méthodes de production de nouveaux composés organiques azotés, tels que la tylosine et la desmycosine |
US4161523A (en) * | 1972-11-15 | 1979-07-17 | Schering Corporation | Rosamicin esters, acid addition salts and methods for production thereof |
-
1981
- 1981-05-27 ZA ZA00813578A patent/ZA813578B/xx unknown
- 1981-06-09 CA CA000379332A patent/CA1172190A/en not_active Expired
- 1981-06-09 PH PH25730A patent/PH15924A/en unknown
- 1981-06-09 PT PT73164A patent/PT73164B/pt unknown
- 1981-06-09 NZ NZ197360A patent/NZ197360A/en unknown
- 1981-06-09 SU SU813345999A patent/SU1134120A3/ru active
- 1981-06-09 AU AU71447/81A patent/AU544358B2/en not_active Ceased
- 1981-06-09 YU YU01442/81A patent/YU144281A/xx unknown
- 1981-06-09 RO RO81104536A patent/RO81017A/ro unknown
- 1981-06-10 CS CS814339A patent/CS225842B2/cs unknown
- 1981-06-10 AT AT81302572T patent/ATE6468T1/de not_active IP Right Cessation
- 1981-06-10 GB GB8117838A patent/GB2077730B/en not_active Expired
- 1981-06-10 EP EP81302572A patent/EP0042694B1/en not_active Expired
- 1981-06-10 DE DE8181302572A patent/DE3162501D1/de not_active Expired
- 1981-06-11 IE IE1296/81A patent/IE51613B1/en active Protection Beyond IP Right Term
- 1981-06-11 JP JP9072481A patent/JPS5731698A/ja active Pending
- 1981-06-11 HU HU811738A patent/HU189979B/hu unknown
- 1981-06-11 ES ES502981A patent/ES502981A0/es active Granted
- 1981-06-11 GR GR65216A patent/GR75276B/el unknown
- 1981-06-11 DK DK255581A patent/DK255581A/da not_active Application Discontinuation
- 1981-06-11 FI FI811827A patent/FI811827L/fi not_active Application Discontinuation
- 1981-06-11 IL IL63076A patent/IL63076A/xx unknown
- 1981-06-12 DD DD81230762A patent/DD159645A5/de unknown
- 1981-06-12 KR KR1019810002108A patent/KR840001957B1/ko active
Also Published As
Publication number | Publication date |
---|---|
DE3162501D1 (en) | 1984-04-12 |
DK255581A (da) | 1981-12-13 |
AU544358B2 (en) | 1985-05-23 |
PT73164B (en) | 1982-07-16 |
CA1172190A (en) | 1984-08-07 |
IL63076A0 (en) | 1981-09-13 |
PH15924A (en) | 1983-04-26 |
GR75276B (es) | 1984-07-13 |
SU1134120A3 (ru) | 1985-01-07 |
DD159645A5 (de) | 1983-03-23 |
PT73164A (en) | 1981-07-01 |
ZA813578B (en) | 1983-01-26 |
GB2077730B (en) | 1984-06-20 |
JPS5731698A (en) | 1982-02-20 |
AU7144781A (en) | 1981-12-17 |
CS225842B2 (en) | 1984-02-13 |
ATE6468T1 (de) | 1984-03-15 |
NZ197360A (en) | 1984-03-30 |
KR840001957B1 (ko) | 1984-10-26 |
FI811827L (fi) | 1981-12-13 |
EP0042694B1 (en) | 1984-03-07 |
IL63076A (en) | 1984-07-31 |
GB2077730A (en) | 1981-12-23 |
IE811296L (en) | 1981-12-12 |
YU144281A (en) | 1983-09-30 |
EP0042694A1 (en) | 1981-12-30 |
ES502981A0 (es) | 1982-04-16 |
RO81017A (ro) | 1983-02-01 |
KR830006430A (ko) | 1983-09-24 |
HU189979B (en) | 1986-08-28 |
IE51613B1 (en) | 1987-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FD1A | Patent lapsed |
Effective date: 19970401 |