GB1013837A - Erythromycin salts and esters - Google Patents

Erythromycin salts and esters

Info

Publication number
GB1013837A
GB1013837A GB46362/62A GB4636262A GB1013837A GB 1013837 A GB1013837 A GB 1013837A GB 46362/62 A GB46362/62 A GB 46362/62A GB 4636262 A GB4636262 A GB 4636262A GB 1013837 A GB1013837 A GB 1013837A
Authority
GB
United Kingdom
Prior art keywords
erythromycin
lactate
treatment
water
salt
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB46362/62A
Inventor
Giuseppe Valenti
Aldo Albano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierrel SpA
Original Assignee
Pierrel SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierrel SpA filed Critical Pierrel SpA
Priority to GB46362/62A priority Critical patent/GB1013837A/en
Priority to BR154961/63A priority patent/BR6354961D0/en
Priority to DK563563AA priority patent/DK108729C/en
Priority to ES294237A priority patent/ES294237A1/en
Publication of GB1013837A publication Critical patent/GB1013837A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

The invention relates to erythromycin lactate. This compound is produced by reacting a solution of erythromycin in an organic solvent (or mixture of organic solvents) in which erythromycin lactate is insoluble, e.g. butyl acetate, with an equivalent amount or an excess of lactic acid. Erythromycin lactate may be converted to (a) erythromycin base by treatment with an alkaline inorganic or organic substance, or (b) an ester or other salt of erythromycin by treatment with the appropriate salt, acid chloride or acid anhydride. Examples describe the preparation of erythromycin propionylester, erythromycin lauryl sulphate, erythromycin thiocyanate, erythromycin lactobionate and erythromycin sulphamate. Erythromycin lactate may be prepared directly from a solvent extract of a fermentation broth. It is soluble in water to produce a pH of 5.5. An injection comprises erythromycin lactate and an injectable liquid carrier, e.g. water. Specifications 708,159, 768,043 and 885,528 are referred to.
GB46362/62A 1962-12-07 1962-12-07 Erythromycin salts and esters Expired GB1013837A (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
GB46362/62A GB1013837A (en) 1962-12-07 1962-12-07 Erythromycin salts and esters
BR154961/63A BR6354961D0 (en) 1962-12-07 1963-11-29 A PROCESS OF OBTAINING NEW ERITROMICIN DERIVATIVES
DK563563AA DK108729C (en) 1962-12-07 1963-12-03 Method for purifying erythromycin.
ES294237A ES294237A1 (en) 1962-12-07 1963-12-21 Procedure for the production of a new soluble salt of erythromycin. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB46362/62A GB1013837A (en) 1962-12-07 1962-12-07 Erythromycin salts and esters

Publications (1)

Publication Number Publication Date
GB1013837A true GB1013837A (en) 1965-12-22

Family

ID=10440936

Family Applications (1)

Application Number Title Priority Date Filing Date
GB46362/62A Expired GB1013837A (en) 1962-12-07 1962-12-07 Erythromycin salts and esters

Country Status (4)

Country Link
BR (1) BR6354961D0 (en)
DK (1) DK108729C (en)
ES (1) ES294237A1 (en)
GB (1) GB1013837A (en)

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011527292A (en) * 2008-07-10 2011-10-27 リウ、リー Hydrates of erythromycin salts, methods for their production and use
CN102532223A (en) * 2010-10-08 2012-07-04 塔科敏斯基制药厂波尔法合资公司 Process for the preparation of 11,12-cyclic erythromycin a carbonate lactobionate and the use thereof
CN104402947A (en) * 2014-11-06 2015-03-11 哈药集团制药总厂 Preparation method of aseptic azithromycin lactobionate
US9409940B2 (en) 2011-08-26 2016-08-09 Hec Pharm Co., Ltd. Preparation process of erythromycin thiocyanate
CN106279320A (en) * 2016-08-22 2017-01-04 宁夏启元药业有限公司 A kind of extracting method of erythromycin lactate
CN113150044A (en) * 2021-04-28 2021-07-23 宜昌东阳光生化制药有限公司 Purification method of erythromycin thiocyanate

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011527292A (en) * 2008-07-10 2011-10-27 リウ、リー Hydrates of erythromycin salts, methods for their production and use
CN102532223A (en) * 2010-10-08 2012-07-04 塔科敏斯基制药厂波尔法合资公司 Process for the preparation of 11,12-cyclic erythromycin a carbonate lactobionate and the use thereof
US9409940B2 (en) 2011-08-26 2016-08-09 Hec Pharm Co., Ltd. Preparation process of erythromycin thiocyanate
CN104402947A (en) * 2014-11-06 2015-03-11 哈药集团制药总厂 Preparation method of aseptic azithromycin lactobionate
CN106279320A (en) * 2016-08-22 2017-01-04 宁夏启元药业有限公司 A kind of extracting method of erythromycin lactate
CN113150044A (en) * 2021-04-28 2021-07-23 宜昌东阳光生化制药有限公司 Purification method of erythromycin thiocyanate

Also Published As

Publication number Publication date
BR6354961D0 (en) 1973-07-12
DK108729C (en) 1968-02-05
ES294237A1 (en) 1967-12-01

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