GB1013837A - Erythromycin salts and esters - Google Patents
Erythromycin salts and estersInfo
- Publication number
- GB1013837A GB1013837A GB46362/62A GB4636262A GB1013837A GB 1013837 A GB1013837 A GB 1013837A GB 46362/62 A GB46362/62 A GB 46362/62A GB 4636262 A GB4636262 A GB 4636262A GB 1013837 A GB1013837 A GB 1013837A
- Authority
- GB
- United Kingdom
- Prior art keywords
- erythromycin
- lactate
- treatment
- water
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
- C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
- C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
Abstract
The invention relates to erythromycin lactate. This compound is produced by reacting a solution of erythromycin in an organic solvent (or mixture of organic solvents) in which erythromycin lactate is insoluble, e.g. butyl acetate, with an equivalent amount or an excess of lactic acid. Erythromycin lactate may be converted to (a) erythromycin base by treatment with an alkaline inorganic or organic substance, or (b) an ester or other salt of erythromycin by treatment with the appropriate salt, acid chloride or acid anhydride. Examples describe the preparation of erythromycin propionylester, erythromycin lauryl sulphate, erythromycin thiocyanate, erythromycin lactobionate and erythromycin sulphamate. Erythromycin lactate may be prepared directly from a solvent extract of a fermentation broth. It is soluble in water to produce a pH of 5.5. An injection comprises erythromycin lactate and an injectable liquid carrier, e.g. water. Specifications 708,159, 768,043 and 885,528 are referred to.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB46362/62A GB1013837A (en) | 1962-12-07 | 1962-12-07 | Erythromycin salts and esters |
BR154961/63A BR6354961D0 (en) | 1962-12-07 | 1963-11-29 | A PROCESS OF OBTAINING NEW ERITROMICIN DERIVATIVES |
DK563563AA DK108729C (en) | 1962-12-07 | 1963-12-03 | Method for purifying erythromycin. |
ES294237A ES294237A1 (en) | 1962-12-07 | 1963-12-21 | Procedure for the production of a new soluble salt of erythromycin. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB46362/62A GB1013837A (en) | 1962-12-07 | 1962-12-07 | Erythromycin salts and esters |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1013837A true GB1013837A (en) | 1965-12-22 |
Family
ID=10440936
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB46362/62A Expired GB1013837A (en) | 1962-12-07 | 1962-12-07 | Erythromycin salts and esters |
Country Status (4)
Country | Link |
---|---|
BR (1) | BR6354961D0 (en) |
DK (1) | DK108729C (en) |
ES (1) | ES294237A1 (en) |
GB (1) | GB1013837A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011527292A (en) * | 2008-07-10 | 2011-10-27 | リウ、リー | Hydrates of erythromycin salts, methods for their production and use |
CN102532223A (en) * | 2010-10-08 | 2012-07-04 | 塔科敏斯基制药厂波尔法合资公司 | Process for the preparation of 11,12-cyclic erythromycin a carbonate lactobionate and the use thereof |
CN104402947A (en) * | 2014-11-06 | 2015-03-11 | 哈药集团制药总厂 | Preparation method of aseptic azithromycin lactobionate |
US9409940B2 (en) | 2011-08-26 | 2016-08-09 | Hec Pharm Co., Ltd. | Preparation process of erythromycin thiocyanate |
CN106279320A (en) * | 2016-08-22 | 2017-01-04 | 宁夏启元药业有限公司 | A kind of extracting method of erythromycin lactate |
CN113150044A (en) * | 2021-04-28 | 2021-07-23 | 宜昌东阳光生化制药有限公司 | Purification method of erythromycin thiocyanate |
-
1962
- 1962-12-07 GB GB46362/62A patent/GB1013837A/en not_active Expired
-
1963
- 1963-11-29 BR BR154961/63A patent/BR6354961D0/en unknown
- 1963-12-03 DK DK563563AA patent/DK108729C/en active
- 1963-12-21 ES ES294237A patent/ES294237A1/en not_active Expired
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011527292A (en) * | 2008-07-10 | 2011-10-27 | リウ、リー | Hydrates of erythromycin salts, methods for their production and use |
CN102532223A (en) * | 2010-10-08 | 2012-07-04 | 塔科敏斯基制药厂波尔法合资公司 | Process for the preparation of 11,12-cyclic erythromycin a carbonate lactobionate and the use thereof |
US9409940B2 (en) | 2011-08-26 | 2016-08-09 | Hec Pharm Co., Ltd. | Preparation process of erythromycin thiocyanate |
CN104402947A (en) * | 2014-11-06 | 2015-03-11 | 哈药集团制药总厂 | Preparation method of aseptic azithromycin lactobionate |
CN106279320A (en) * | 2016-08-22 | 2017-01-04 | 宁夏启元药业有限公司 | A kind of extracting method of erythromycin lactate |
CN113150044A (en) * | 2021-04-28 | 2021-07-23 | 宜昌东阳光生化制药有限公司 | Purification method of erythromycin thiocyanate |
Also Published As
Publication number | Publication date |
---|---|
BR6354961D0 (en) | 1973-07-12 |
DK108729C (en) | 1968-02-05 |
ES294237A1 (en) | 1967-12-01 |
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