GB1388861A - Process for preparing aminopropanol derivatives - Google Patents

Process for preparing aminopropanol derivatives

Info

Publication number
GB1388861A
GB1388861A GB2063872A GB2063872A GB1388861A GB 1388861 A GB1388861 A GB 1388861A GB 2063872 A GB2063872 A GB 2063872A GB 2063872 A GB2063872 A GB 2063872A GB 1388861 A GB1388861 A GB 1388861A
Authority
GB
United Kingdom
Prior art keywords
compounds
group
acid addition
addition salts
toxic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB2063872A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Publication of GB1388861A publication Critical patent/GB1388861A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids RP(=O)(OH)2; Thiophosphonic acids, i.e. RP(=X)(XH)2 (X = S, Se)
    • C07F9/44—Amides thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

1388861 Aminopropanol derivatives TEIKOKU HORMONE MFG CO Ltd 3 May 1972 [7 May 1971] 20638/72 Heading C2C The invention comprises a process for the preparation of aminopropanol derivatives of the Formula III wherein Ar is a substituted or unsubstituted phenylene or naphthylene group, Ac is an organic acyl group or a triphenylmethyl group, Y is H, a monovalent hydrocarbon group having up to 12 carbon atoms, or an organic acyl group, or Y and Ac together with the nitrogen atom to which they are attached for a cyclic dicarboximido group, Z is H or a protecting group bonded to the oxygen atom by an aliphatic ether linkage, and R is alkyl or aralkyl group and non-toxic acid addition salts thereof, the compounds being novel when Z is a protecting groups as defined above, by reacting compounds of the formula or non-toxic acid addition salts thereof with compounds of the formula and, if desired, converting the compounds of Formula III so obtained to non-toxic acid addition salts. 4-Acetamido-2,3-xylenol is obtained by acetylating 4-amino-2,3-xylenol. 1 - Isopropyl - 3 - azetidinol and 1 - tert.- butyl-3-azetidinol are prepared by the hydrogenolysis of 3-benzyloxy-1-isopropylazetidine and 3- benzyloxy - 1 - tert. - butylazetidine respectively, which are obtained by reacting 2-benzyloxy-1,3- dichloropropene with isopropylamine and tert.- butylamine respectively. Pharmaceutical compositions contain the above novel compounds or non-toxic acid addition salts thereof and pharmaceutically acceptable carriers or diluents. The compounds are used as antiulcerative agents. Reference has been directed by the Comptroller to Specifications 1,078,852, 1,185,044, 1,185,045, 1,185,046, 1,199,037 and 1,270,723.
GB2063872A 1971-05-07 1972-05-03 Process for preparing aminopropanol derivatives Expired GB1388861A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP46029864A JPS5123489B1 (en) 1971-05-07 1971-05-07

Publications (1)

Publication Number Publication Date
GB1388861A true GB1388861A (en) 1975-03-26

Family

ID=12287825

Family Applications (1)

Application Number Title Priority Date Filing Date
GB2063872A Expired GB1388861A (en) 1971-05-07 1972-05-03 Process for preparing aminopropanol derivatives

Country Status (14)

Country Link
JP (1) JPS5123489B1 (en)
AT (1) AT318562B (en)
AU (1) AU466675B2 (en)
BE (1) BE783086A (en)
CA (1) CA1005073A (en)
CH (1) CH574904A5 (en)
DK (1) DK137796B (en)
ES (2) ES402471A1 (en)
FR (1) FR2137601B1 (en)
GB (1) GB1388861A (en)
LU (1) LU65291A1 (en)
NL (1) NL153518B (en)
NO (2) NO139559C (en)
SE (1) SE393601B (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013865A1 (en) * 1990-03-09 1991-09-19 Isis Innovation Limited Antiarrhythmic agents

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS54155497U (en) * 1978-04-21 1979-10-29

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1349357A (en) * 1969-11-28 1974-04-03 Teikoku Hormone Mfg Co Ltd Propylamines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1991013865A1 (en) * 1990-03-09 1991-09-19 Isis Innovation Limited Antiarrhythmic agents

Also Published As

Publication number Publication date
FR2137601A1 (en) 1972-12-29
DE2222471A1 (en) 1972-12-21
NO146954C (en) 1983-01-12
CA1005073A (en) 1977-02-08
NO139559B (en) 1978-12-27
ES429697A1 (en) 1976-10-01
NO139559C (en) 1979-04-04
AT318562B (en) 1974-10-25
JPS5123489B1 (en) 1976-07-17
NO146954B (en) 1982-09-27
AU4202172A (en) 1973-11-15
DK137796C (en) 1978-10-16
CH574904A5 (en) 1976-04-30
NL153518B (en) 1977-06-15
BE783086A (en) 1972-09-01
DK137796B (en) 1978-05-08
LU65291A1 (en) 1972-08-23
DE2222471B2 (en) 1977-06-23
AU466675B2 (en) 1975-11-06
NL7206111A (en) 1972-11-09
FR2137601B1 (en) 1975-12-26
ES402471A1 (en) 1976-01-01
SE393601B (en) 1977-05-16
NO780220L (en) 1972-11-08

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee