GB1349357A - Propylamines - Google Patents

Propylamines

Info

Publication number
GB1349357A
GB1349357A GB5650170A GB5650170A GB1349357A GB 1349357 A GB1349357 A GB 1349357A GB 5650170 A GB5650170 A GB 5650170A GB 5650170 A GB5650170 A GB 5650170A GB 1349357 A GB1349357 A GB 1349357A
Authority
GB
United Kingdom
Prior art keywords
group
propylamines
substituted
formula
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB5650170A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2654870A external-priority patent/JPS4815925B1/ja
Priority claimed from JP45063377A external-priority patent/JPS4943949B1/ja
Priority claimed from JP9973370A external-priority patent/JPS4943950B1/ja
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Priority to GB1349359D priority Critical patent/GB1349359A/en
Publication of GB1349357A publication Critical patent/GB1349357A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
    • C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
    • C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C217/28—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines
    • C07C217/30—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring
    • C07C217/32—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted
    • C07C217/34—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having one amino group and at least two singly-bound oxygen atoms, with at least one being part of an etherified hydroxy group, bound to the carbon skeleton, e.g. ethers of polyhydroxy amines having the oxygen atom of at least one of the etherified hydroxy groups further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring being further substituted by halogen atoms, by trihalomethyl, nitro or nitroso groups, or by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
    • C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/08—Indoles; Hydrogenated indoles with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
    • C07D319/14—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems
    • C07D319/16—1,4-Dioxanes; Hydrogenated 1,4-dioxanes condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D319/18—Ethylenedioxybenzenes, not substituted on the hetero ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1349357 Propylamines TEIKOKU HORMONE MFG CO Ltd 27 Nov 1970 [28 Nov 1969 31 March 1970 (2) 21 July 1970 16 Oct 1970 13 Nov 1970] 56501/70 Heading C2C Propylamines of the general Formula I Ar-OCH 2 CH(OZ)CH 2 NHR wherein Ar represents a substituted or unsubstituted aryl group, Z represents a hydrogen atom or an aliphatic or araliphatic group and R represents an alkyl or aralkyl group or acid addition salts thereof, are prepared by reacting azetidines of the general formula with phenols of the formula ArOH and, if desired or necessary, removing the aliphatic or araliphatic group to form propylamines in which Z represents hydrogen. Ar represents a wide range of aryl groups and when Ar represents a naphthyl group, R has the above significance and Z represents a hydrogen atom or a substituted or unsubstituted benzyl group, the product of the above process may be hydrogenated under substantially atmospheric pressure in the presence of a solvent to form a propylamine where Ar represents a 5,6,7,8,-tetrahydronaphthyl group and Z represents hydrogen or a substituted or unsubstituted benzyl group. The propylamines of Formula I and acid addition salts thereof are novel when Z is other than hydrogen and the following propanolamines of Formula I are novel: 1-(4<SP>1</SP>-aminophenoxy)-, 1-(2<SP>1</SP>,3<SP>1</SP>-dimethyl- 4<SP>1</SP>-methoxyphenoxy) - and 1-(4-hydroxyphenoxy)-3-(t-butylamino)-propan-2-ols and acid addition salts thereof. Pharmaceutical compositions comprise a novel propylamine in association with a carrier. When Z is a benzyl or substituted benzyl group the active ingredients are antiulcerative agents, and the second propanolamine above possesses #- adrenergic blocking and stimulating activity.
GB5650170A 1969-11-28 1970-11-27 Propylamines Expired GB1349357A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB1349359D GB1349359A (en) 1970-11-27 1970-11-27 Azetidines

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP9502769 1969-11-28
JP2654870A JPS4815925B1 (en) 1970-03-31 1970-03-31
JP2654970 1970-03-31
JP45063377A JPS4943949B1 (en) 1970-07-21 1970-07-21
JP9042970 1970-10-16
JP9973370A JPS4943950B1 (en) 1970-11-13 1970-11-13

Publications (1)

Publication Number Publication Date
GB1349357A true GB1349357A (en) 1974-04-03

Family

ID=27549297

Family Applications (2)

Application Number Title Priority Date Filing Date
GB2014270A Expired GB1349358A (en) 1969-11-28 1970-11-27 Hydrogenation process
GB5650170A Expired GB1349357A (en) 1969-11-28 1970-11-27 Propylamines

Family Applications Before (1)

Application Number Title Priority Date Filing Date
GB2014270A Expired GB1349358A (en) 1969-11-28 1970-11-27 Hydrogenation process

Country Status (6)

Country Link
CH (2) CH561171A5 (en)
DE (2) DE2058532C3 (en)
FR (1) FR2073434B1 (en)
GB (2) GB1349358A (en)
NL (1) NL145842B (en)
SE (1) SE378102B (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006614A2 (en) * 1978-06-27 1980-01-09 Merck & Co. Inc. Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same
US5574156A (en) * 1989-05-31 1996-11-12 Florida State University β-lactams used in preparing taxol
US6562962B2 (en) 1991-09-23 2003-05-13 Florida State University Preparation of substituted isoserine esters using metal alkoxides and β-lactams

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5123489B1 (en) * 1971-05-07 1976-07-17
DE2644833A1 (en) * 1976-10-05 1978-04-20 Boehringer Sohn Ingelheim NEW 1-ARYLOXY-2-HYDROXY-3-ALKYLENE AMINOPROPANES AND METHOD FOR THE PRODUCTION THEREOF

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL6909640A (en) * 1968-06-27 1969-12-30

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0006614A2 (en) * 1978-06-27 1980-01-09 Merck & Co. Inc. Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same
EP0006614A3 (en) * 1978-06-27 1980-01-23 Merck & Co. Inc. Pyridyl- and imidazopyridyloxypropanolamines, process for preparing the same and pharmaceutical compositions containing the same
US5574156A (en) * 1989-05-31 1996-11-12 Florida State University β-lactams used in preparing taxol
US6562962B2 (en) 1991-09-23 2003-05-13 Florida State University Preparation of substituted isoserine esters using metal alkoxides and β-lactams

Also Published As

Publication number Publication date
GB1349358A (en) 1974-04-03
DE2058532A1 (en) 1972-02-03
CH549013A (en) 1974-05-15
NL145842B (en) 1975-05-15
CH561171A5 (en) 1975-04-30
DE2058532B2 (en) 1978-11-09
FR2073434A1 (en) 1971-10-01
FR2073434B1 (en) 1975-08-01
DE2065365B2 (en) 1981-08-13
DE2065365C3 (en) 1982-05-06
SE378102B (en) 1975-08-18
NL7017367A (en) 1971-06-02
DE2058532C3 (en) 1979-08-09
DE2065365A1 (en) 1973-05-17

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Legal Events

Date Code Title Description
49R Reference inserted (sect. 9/1949)
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee