GB1382571A - Quinoline derivatives processes for their preparation and compo sitions incorporating them - Google Patents
Quinoline derivatives processes for their preparation and compo sitions incorporating themInfo
- Publication number
- GB1382571A GB1382571A GB4081473A GB4081473A GB1382571A GB 1382571 A GB1382571 A GB 1382571A GB 4081473 A GB4081473 A GB 4081473A GB 4081473 A GB4081473 A GB 4081473A GB 1382571 A GB1382571 A GB 1382571A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- alkyl
- incorporating
- preparation
- phenylthio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 abstract 3
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 abstract 3
- NDDZXHOCOKCNBM-UHFFFAOYSA-N 5-nitroquinoline Chemical class C1=CC=C2C([N+](=O)[O-])=CC=CC2=N1 NDDZXHOCOKCNBM-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- -1 phenylthio, tetrahydrofurfuryl Chemical group 0.000 abstract 2
- GKPRSAKLBYSVKI-UHFFFAOYSA-N (5-nitroquinolin-8-yl) N-methylcarbamate Chemical compound [N+](=O)([O-])C1=C2C=CC=NC2=C(C=C1)OC(NC)=O GKPRSAKLBYSVKI-UHFFFAOYSA-N 0.000 abstract 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
- 125000006700 (C1-C6) alkylthio group Chemical group 0.000 abstract 1
- CKDWPUIZGOQOOM-UHFFFAOYSA-N Carbamyl chloride Chemical compound NC(Cl)=O CKDWPUIZGOQOOM-UHFFFAOYSA-N 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 1
- 125000004414 alkyl thio group Chemical group 0.000 abstract 1
- 125000004391 aryl sulfonyl group Chemical group 0.000 abstract 1
- 230000003115 biocidal effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000000855 fungicidal effect Effects 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 239000012948 isocyanate Substances 0.000 abstract 1
- 150000002513 isocyanates Chemical class 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- RJIWZDNTCBHXAL-UHFFFAOYSA-N nitroxoline Chemical compound C1=CN=C2C(O)=CC=C([N+]([O-])=O)C2=C1 RJIWZDNTCBHXAL-UHFFFAOYSA-N 0.000 abstract 1
- 125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/32—Esters
- C07D215/34—Carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Quinoline Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7230894A FR2197512B1 (enExample) | 1972-08-31 | 1972-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1382571A true GB1382571A (en) | 1975-02-05 |
Family
ID=9103729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4081473A Expired GB1382571A (en) | 1972-08-31 | 1973-08-30 | Quinoline derivatives processes for their preparation and compo sitions incorporating them |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS4966683A (enExample) |
| BE (1) | BE804218A (enExample) |
| CA (1) | CA1010871A (enExample) |
| CH (1) | CH585718A5 (enExample) |
| DD (1) | DD107573A5 (enExample) |
| DE (1) | DE2344010A1 (enExample) |
| ES (1) | ES418331A1 (enExample) |
| FR (1) | FR2197512B1 (enExample) |
| GB (1) | GB1382571A (enExample) |
| HU (1) | HU167953B (enExample) |
| IL (1) | IL42969A (enExample) |
| IT (1) | IT990427B (enExample) |
| NL (1) | NL7311921A (enExample) |
| SU (2) | SU500756A3 (enExample) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020063824A1 (zh) * | 2018-09-29 | 2020-04-02 | 江苏亚虹医药科技有限公司 | 硝羟喹啉前药及其用途 |
| CN111514142A (zh) * | 2020-05-29 | 2020-08-11 | 江苏亚虹医药科技有限公司 | 含硝羟喹啉前药的药物组合物及其制备方法和应用 |
| TWI874355B (zh) * | 2020-02-14 | 2025-03-01 | 中國大陸商江蘇亞虹醫藥科技股份有限公司 | 硝羥喹啉前藥及其用途 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0387510A1 (de) * | 1989-02-10 | 1990-09-19 | Bayer Ag | Substituierte 8-Carbamoyloxychinolin-Derivate, Verfahren zu deren Herstellung, sowie deren Verwendung zur Bekämpfung von Schädlingen |
| RU2154636C1 (ru) * | 1999-07-30 | 2000-08-20 | Субоч Георгий Анатольевич | Способ получения 5-нитро-8-оксихинолина |
-
1972
- 1972-08-31 FR FR7230894A patent/FR2197512B1/fr not_active Expired
-
1973
- 1973-08-13 IL IL42969A patent/IL42969A/en unknown
- 1973-08-28 CA CA179,800A patent/CA1010871A/fr not_active Expired
- 1973-08-30 BE BE135109A patent/BE804218A/xx unknown
- 1973-08-30 ES ES418331A patent/ES418331A1/es not_active Expired
- 1973-08-30 CH CH1245173A patent/CH585718A5/xx not_active IP Right Cessation
- 1973-08-30 SU SU1959055A patent/SU500756A3/ru active
- 1973-08-30 JP JP48096772A patent/JPS4966683A/ja active Pending
- 1973-08-30 NL NL7311921A patent/NL7311921A/xx not_active Application Discontinuation
- 1973-08-30 GB GB4081473A patent/GB1382571A/en not_active Expired
- 1973-08-30 HU HURO744A patent/HU167953B/hu unknown
- 1973-08-30 IT IT52248/73A patent/IT990427B/it active
- 1973-08-31 DE DE19732344010 patent/DE2344010A1/de active Pending
- 1973-08-31 DD DD173206A patent/DD107573A5/xx unknown
-
1974
- 1974-10-14 SU SU2066959A patent/SU503519A3/ru active
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020063824A1 (zh) * | 2018-09-29 | 2020-04-02 | 江苏亚虹医药科技有限公司 | 硝羟喹啉前药及其用途 |
| CN111295372A (zh) * | 2018-09-29 | 2020-06-16 | 江苏亚虹医药科技有限公司 | 硝羟喹啉前药及其用途 |
| EP3858814A4 (en) * | 2018-09-29 | 2022-10-05 | Jiangsu Yahong Meditech Co., Ltd. | NITROXOLINE PRODRUG AND ITS USE |
| US12152048B2 (en) | 2018-09-29 | 2024-11-26 | Jiangsu Yahong Meditech Co., Ltd. | Nitroxoline prodrug and use thereof |
| AU2019351494B2 (en) * | 2018-09-29 | 2025-03-13 | Jiangsu Yahong Meditech Co., Ltd. | Nitroxoline prodrug and use thereof |
| TWI874355B (zh) * | 2020-02-14 | 2025-03-01 | 中國大陸商江蘇亞虹醫藥科技股份有限公司 | 硝羥喹啉前藥及其用途 |
| CN111514142A (zh) * | 2020-05-29 | 2020-08-11 | 江苏亚虹医药科技有限公司 | 含硝羟喹啉前药的药物组合物及其制备方法和应用 |
| CN111514142B (zh) * | 2020-05-29 | 2021-04-06 | 江苏亚虹医药科技股份有限公司 | 含硝羟喹啉前药的药物组合物及其制备方法和应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| DD107573A5 (enExample) | 1974-08-12 |
| IT990427B (it) | 1975-06-20 |
| NL7311921A (enExample) | 1974-03-04 |
| JPS4966683A (enExample) | 1974-06-27 |
| FR2197512A1 (enExample) | 1974-03-29 |
| IL42969A0 (en) | 1973-11-28 |
| BE804218A (fr) | 1974-02-28 |
| CA1010871A (fr) | 1977-05-24 |
| CH585718A5 (enExample) | 1977-03-15 |
| IL42969A (en) | 1977-01-31 |
| SU500756A3 (ru) | 1976-01-25 |
| ES418331A1 (es) | 1976-03-16 |
| FR2197512B1 (enExample) | 1977-01-14 |
| SU503519A3 (ru) | 1976-02-15 |
| DE2344010A1 (de) | 1974-03-07 |
| HU167953B (enExample) | 1976-01-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |