SU503519A3 - Способ получени производных 5-нитрохинолина - Google Patents
Способ получени производных 5-нитрохинолинаInfo
- Publication number
- SU503519A3 SU503519A3 SU2066959A SU2066959A SU503519A3 SU 503519 A3 SU503519 A3 SU 503519A3 SU 2066959 A SU2066959 A SU 2066959A SU 2066959 A SU2066959 A SU 2066959A SU 503519 A3 SU503519 A3 SU 503519A3
- Authority
- SU
- USSR - Soviet Union
- Prior art keywords
- nitroquinoline
- obtaining derivatives
- nitro
- phenylthio
- alkylthio
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/20—Oxygen atoms
- C07D215/24—Oxygen atoms attached in position 8
- C07D215/26—Alcohols; Ethers thereof
- C07D215/32—Esters
- C07D215/34—Carbamates
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Quinoline Compounds (AREA)
Description
(54) СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 5-НИТРОХИНОЛИНА
Пример 2. 5-Нитро-8-(Ы-метил-Ы-фенилтиокарбамоилокси )-хииолин. Провод процесс , как в примере 1, по исход из 33 г дифенилдисульфида и 22,8 г хлористого сульфурила получают 48 т 5-11итро-8-(Ы-метил-Ы-феиилтиокарбамоилокси )-хинолииа в виде твердого продукта цвета охры, плав щегос при 88°С.
Этот продукт можно очистить перекристаллизацией из эфира.
Найдено, %: С 57,5; И 3,7; N 11,8; S 9,3.
С17П1зМзО45 (355,36).
Вычислено, %: С 57,47; Н 3,68; N 11,82; S 9,02.
Claims (1)
1. Способ получени производных 5-нитро- 20 хинолипа формулы I
где RI - метил и R2 - алкилтио- или фенилтиогруппа ,
отличающийс тем, что 5-нитро-8-(метилкарба .моилокси)-хинолин подвергают взаимодействию в присутствии Н1,елочного агента с галогелидом формулы,
RaHal,
где R2 алкилтио-, фенилтиогруппы и Hal- атом галогена, с последующим выделением целевого продукта известными приемами.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7230894A FR2197512B1 (ru) | 1972-08-31 | 1972-08-31 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SU503519A3 true SU503519A3 (ru) | 1976-02-15 |
Family
ID=9103729
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1959055A SU500756A3 (ru) | 1972-08-31 | 1973-08-30 | Способ получени производных 5-нитрохинолина |
| SU2066959A SU503519A3 (ru) | 1972-08-31 | 1974-10-14 | Способ получени производных 5-нитрохинолина |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SU1959055A SU500756A3 (ru) | 1972-08-31 | 1973-08-30 | Способ получени производных 5-нитрохинолина |
Country Status (14)
| Country | Link |
|---|---|
| JP (1) | JPS4966683A (ru) |
| BE (1) | BE804218A (ru) |
| CA (1) | CA1010871A (ru) |
| CH (1) | CH585718A5 (ru) |
| DD (1) | DD107573A5 (ru) |
| DE (1) | DE2344010A1 (ru) |
| ES (1) | ES418331A1 (ru) |
| FR (1) | FR2197512B1 (ru) |
| GB (1) | GB1382571A (ru) |
| HU (1) | HU167953B (ru) |
| IL (1) | IL42969A (ru) |
| IT (1) | IT990427B (ru) |
| NL (1) | NL7311921A (ru) |
| SU (2) | SU500756A3 (ru) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0387510A1 (de) * | 1989-02-10 | 1990-09-19 | Bayer Ag | Substituierte 8-Carbamoyloxychinolin-Derivate, Verfahren zu deren Herstellung, sowie deren Verwendung zur Bekämpfung von Schädlingen |
| JP2022502510A (ja) * | 2018-09-29 | 2022-01-11 | 江▲蘇▼▲亞▼虹医▲薬▼科技股▲フン▼有限公司Jiangsu Yahong Meditech Co., Ltd | ニトロキソリンプロドラッグ及びその使用 |
| CN111514142B (zh) * | 2020-05-29 | 2021-04-06 | 江苏亚虹医药科技股份有限公司 | 含硝羟喹啉前药的药物组合物及其制备方法和应用 |
-
1972
- 1972-08-31 FR FR7230894A patent/FR2197512B1/fr not_active Expired
-
1973
- 1973-08-13 IL IL42969A patent/IL42969A/en unknown
- 1973-08-28 CA CA179,800A patent/CA1010871A/fr not_active Expired
- 1973-08-30 HU HURO744A patent/HU167953B/hu unknown
- 1973-08-30 CH CH1245173A patent/CH585718A5/xx not_active IP Right Cessation
- 1973-08-30 NL NL7311921A patent/NL7311921A/xx not_active Application Discontinuation
- 1973-08-30 SU SU1959055A patent/SU500756A3/ru active
- 1973-08-30 ES ES418331A patent/ES418331A1/es not_active Expired
- 1973-08-30 GB GB4081473A patent/GB1382571A/en not_active Expired
- 1973-08-30 BE BE135109A patent/BE804218A/xx unknown
- 1973-08-30 JP JP48096772A patent/JPS4966683A/ja active Pending
- 1973-08-30 IT IT52248/73A patent/IT990427B/it active
- 1973-08-31 DD DD173206A patent/DD107573A5/xx unknown
- 1973-08-31 DE DE19732344010 patent/DE2344010A1/de active Pending
-
1974
- 1974-10-14 SU SU2066959A patent/SU503519A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| ES418331A1 (es) | 1976-03-16 |
| FR2197512A1 (ru) | 1974-03-29 |
| SU500756A3 (ru) | 1976-01-25 |
| IL42969A (en) | 1977-01-31 |
| CA1010871A (fr) | 1977-05-24 |
| HU167953B (ru) | 1976-01-28 |
| IT990427B (it) | 1975-06-20 |
| DE2344010A1 (de) | 1974-03-07 |
| GB1382571A (en) | 1975-02-05 |
| JPS4966683A (ru) | 1974-06-27 |
| IL42969A0 (en) | 1973-11-28 |
| DD107573A5 (ru) | 1974-08-12 |
| CH585718A5 (ru) | 1977-03-15 |
| NL7311921A (ru) | 1974-03-04 |
| FR2197512B1 (ru) | 1977-01-14 |
| BE804218A (fr) | 1974-02-28 |
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