GB1381422A - Substituted 1-benzyl-indazole-3-carboxylic acids - Google Patents
Substituted 1-benzyl-indazole-3-carboxylic acidsInfo
- Publication number
- GB1381422A GB1381422A GB780673A GB780673A GB1381422A GB 1381422 A GB1381422 A GB 1381422A GB 780673 A GB780673 A GB 780673A GB 780673 A GB780673 A GB 780673A GB 1381422 A GB1381422 A GB 1381422A
- Authority
- GB
- United Kingdom
- Prior art keywords
- indazole
- chlorobenzyl
- halogen
- ome
- feb
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- CDRCOZFGMPTGBL-UHFFFAOYSA-N 1-benzylindazole-3-carboxylic acid Chemical class C12=CC=CC=C2C(C(=O)O)=NN1CC1=CC=CC=C1 CDRCOZFGMPTGBL-UHFFFAOYSA-N 0.000 title 1
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- LZSHJNODQMYZMN-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]indazole-3-carbonitrile Chemical compound C1=CC(Cl)=CC=C1CN1C2=CC=CC=C2C(C#N)=N1 LZSHJNODQMYZMN-UHFFFAOYSA-N 0.000 abstract 1
- JLPQNSLSENHOML-UHFFFAOYSA-N 1-[(4-chlorophenyl)methyl]indazole-3-carbonyl chloride Chemical compound ClC1=CC=C(CN2N=C(C3=CC=CC=C23)C(=O)Cl)C=C1 JLPQNSLSENHOML-UHFFFAOYSA-N 0.000 abstract 1
- BWKDAAFSXYPQOS-UHFFFAOYSA-N Benzaldehyde glyceryl acetal Chemical compound O1CC(O)COC1C1=CC=CC=C1 BWKDAAFSXYPQOS-UHFFFAOYSA-N 0.000 abstract 1
- 125000000649 benzylidene group Chemical group [H]C(=[*])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 abstract 1
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 abstract 1
- BODKVQNFRLAGBQ-UHFFFAOYSA-N ethyl 1-[(4-chlorophenyl)methyl]-4,5,6,7-tetrahydroindazole-3-carboxylate Chemical compound ClC1=CC=C(CN2N=C(C=3CCCCC23)C(=O)OCC)C=C1 BODKVQNFRLAGBQ-UHFFFAOYSA-N 0.000 abstract 1
- 150000002473 indoazoles Chemical class 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
- C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT48628/72A IT1052111B (it) | 1972-02-29 | 1972-02-29 | Acidi i benzil i h indazol 3 carbossilici sostituiti e loro derivati |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1381422A true GB1381422A (en) | 1975-01-22 |
Family
ID=11267725
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB780673A Expired GB1381422A (en) | 1972-02-29 | 1973-02-16 | Substituted 1-benzyl-indazole-3-carboxylic acids |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US3895026A (enExample) |
| CA (1) | CA994347A (enExample) |
| DE (1) | DE2310031C3 (enExample) |
| FR (1) | FR2181773B1 (enExample) |
| GB (1) | GB1381422A (enExample) |
| HU (1) | HU165172B (enExample) |
| IN (1) | IN139264B (enExample) |
| IT (1) | IT1052111B (enExample) |
| NL (1) | NL179729C (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1050741B (it) * | 1975-12-01 | 1981-03-20 | Acraf | Utilizzazione degli acidi i benzil ih indazol 3 carbossilici sostituiti e loro derivati nel campo della contraccezione femminile |
| US5229408A (en) * | 1988-07-15 | 1993-07-20 | Ici Pharma | 4-carbamoyl-1,2-dihydro-3H-indazol-3-one derivatives |
| US5914405A (en) * | 1997-10-07 | 1999-06-22 | Eli Lilly And Company | Process for preparing 3-substituted indazoles |
| US6001865A (en) * | 1999-05-04 | 1999-12-14 | Angelini Pharmaceuticals Inc. | 3-substituted 1-benzyl-1H-indazole derivatives as antifertility agents |
| KR100424341B1 (ko) * | 2001-10-23 | 2004-03-24 | 하나제약 주식회사 | 1-메틸인다졸-3-카르복실산의 제조방법 |
| CA2513575A1 (en) * | 2003-01-17 | 2004-08-05 | Threshold Pharmaceuticals, Inc. | Treatment of benign prostatic hyperplasia using energolytic agents |
| EP1599196A4 (en) * | 2003-01-17 | 2006-05-31 | Threshold Pharmaceuticals Inc | COMBINATION THERAPIES FOR CANCER TREATMENT |
| CN1956964B (zh) * | 2004-03-24 | 2011-06-15 | 詹森药业有限公司 | 四氢-吲唑大麻素调节剂 |
| WO2005120498A2 (en) * | 2004-06-03 | 2005-12-22 | Threshold Pharmaceuticals, Inc. | Method for synthesis of lonidamine and related indazole derivatives |
| WO2006010077A2 (en) * | 2004-07-08 | 2006-01-26 | Threshold Pharmaceuticals, Inc. | Prodrugs of lonidamine and lonidamine analogs |
| US7514463B2 (en) | 2004-08-20 | 2009-04-07 | University Of Kansas | Lonidamine analogues and their use in male contraception and cancer treatment |
| CN101759644B (zh) * | 2005-08-17 | 2011-11-02 | 杭州民生药业有限公司 | 氯尼达明的结晶形式iii、其制备方法和含有所述结晶形式iii的组合物 |
| CN101735151B (zh) * | 2005-08-17 | 2012-07-04 | 杭州民生药业有限公司 | 氯尼达明的结晶形式i、其制备方法和含有所述结晶形式i的组合物 |
| WO2011005759A2 (en) * | 2009-07-06 | 2011-01-13 | University Of Kansas | Lonidamine analogues for fertility management |
| JP6944442B2 (ja) | 2015-06-12 | 2021-10-06 | ベットーレ リミテッド ライアビリティー カンパニーＶｅｔｔｏｒｅ， Ｌｌｃ | 疾患を治療するためのｍｃｔ４阻害剤 |
| CN110114351B (zh) | 2016-12-12 | 2022-09-20 | 维托尔股份有限公司 | Mct4的杂环抑制剂 |
| CN116438162A (zh) * | 2020-09-17 | 2023-07-14 | 伊赛恩特制药公司 | Mas相关g蛋白受体x4的调节剂及相关产物和方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3007938A (en) * | 1959-04-17 | 1961-11-07 | Sterling Drug Inc | 1-(3-indazolecarbonyl)-hydrazines and their preparation |
| US3145215A (en) * | 1961-12-19 | 1964-08-18 | Sterling Drug Inc | Indazole derivatives |
| IL28032A (en) * | 1966-08-29 | 1971-08-25 | Acraf | Indazol-3-yl-oxyalkanoic acids and process for the preparation thereof |
| US3567721A (en) * | 1968-11-29 | 1971-03-02 | Geigy Chem Corp | Indazolecarboxylic acids and derivatives thereof |
| DE1948793A1 (de) * | 1969-09-26 | 1971-04-01 | Rhein Chemie Rheinau Gmbh | Verfahren zur Herstellung von 4,5,6,7-Tetrahydroindazolen |
-
1972
- 1972-02-29 IT IT48628/72A patent/IT1052111B/it active
-
1973
- 1973-02-09 US US330902A patent/US3895026A/en not_active Expired - Lifetime
- 1973-02-16 GB GB780673A patent/GB1381422A/en not_active Expired
- 1973-02-21 IN IN389/CAL/73A patent/IN139264B/en unknown
- 1973-02-22 CA CA164,360A patent/CA994347A/en not_active Expired
- 1973-02-26 NL NLAANVRAGE7302669,A patent/NL179729C/xx not_active IP Right Cessation
- 1973-02-27 HU HUAI224A patent/HU165172B/hu not_active IP Right Cessation
- 1973-02-28 FR FR7307055A patent/FR2181773B1/fr not_active Expired
- 1973-02-28 DE DE2310031A patent/DE2310031C3/de not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2181773B1 (enExample) | 1975-12-26 |
| NL179729C (nl) | 1986-11-03 |
| NL179729B (nl) | 1986-06-02 |
| DE2310031B2 (de) | 1979-11-15 |
| IN139264B (enExample) | 1976-05-29 |
| FR2181773A1 (enExample) | 1973-12-07 |
| IT1052111B (it) | 1981-06-20 |
| US3895026A (en) | 1975-07-15 |
| NL7302669A (enExample) | 1973-08-31 |
| CA994347A (en) | 1976-08-03 |
| DE2310031C3 (de) | 1980-07-31 |
| HU165172B (enExample) | 1974-07-27 |
| DE2310031A1 (de) | 1973-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |
Effective date: 19930214 |