GB1360354A - Chenodeoxycholic acid - Google Patents
Chenodeoxycholic acidInfo
- Publication number
- GB1360354A GB1360354A GB280372A GB280372A GB1360354A GB 1360354 A GB1360354 A GB 1360354A GB 280372 A GB280372 A GB 280372A GB 280372 A GB280372 A GB 280372A GB 1360354 A GB1360354 A GB 1360354A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methyl
- base
- chenodeoxycholic acid
- cholanate
- kishner
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RUDATBOHQWOJDD-UHFFFAOYSA-N (3beta,5beta,7alpha)-3,7-Dihydroxycholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)CC2 RUDATBOHQWOJDD-UHFFFAOYSA-N 0.000 title abstract 3
- 229960001091 chenodeoxycholic acid Drugs 0.000 title abstract 3
- RUDATBOHQWOJDD-BSWAIDMHSA-N chenodeoxycholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)CC1 RUDATBOHQWOJDD-BSWAIDMHSA-N 0.000 title abstract 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 6
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 abstract 3
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 3
- 239000002585 base Substances 0.000 abstract 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 abstract 2
- 238000005644 Wolff-Kishner reduction reaction Methods 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- BHQCQFFYRZLCQQ-UHFFFAOYSA-N (3alpha,5alpha,7alpha,12alpha)-3,7,12-trihydroxy-cholan-24-oic acid Natural products OC1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 BHQCQFFYRZLCQQ-UHFFFAOYSA-N 0.000 abstract 1
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 abstract 1
- VHUUQVKOLVNVRT-UHFFFAOYSA-N Ammonium hydroxide Chemical compound [NH4+].[OH-] VHUUQVKOLVNVRT-UHFFFAOYSA-N 0.000 abstract 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 abstract 1
- 239000004380 Cholic acid Substances 0.000 abstract 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 abstract 1
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 150000008044 alkali metal hydroxides Chemical class 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 239000000908 ammonium hydroxide Substances 0.000 abstract 1
- -1 chloride or nitrate) Chemical class 0.000 abstract 1
- 229960002471 cholic acid Drugs 0.000 abstract 1
- BHQCQFFYRZLCQQ-OELDTZBJSA-N cholic acid Chemical compound C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC(O)=O)C)[C@@]2(C)[C@@H](O)C1 BHQCQFFYRZLCQQ-OELDTZBJSA-N 0.000 abstract 1
- 235000019416 cholic acid Nutrition 0.000 abstract 1
- KXGVEGMKQFWNSR-UHFFFAOYSA-N deoxycholic acid Natural products C1CC2CC(O)CCC2(C)C2C1C1CCC(C(CCC(O)=O)C)C1(C)C(O)C2 KXGVEGMKQFWNSR-UHFFFAOYSA-N 0.000 abstract 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- 238000006722 reduction reaction Methods 0.000 abstract 1
- PXLIDIMHPNPGMH-UHFFFAOYSA-N sodium chromate Chemical compound [Na+].[Na+].[O-][Cr]([O-])(=O)=O PXLIDIMHPNPGMH-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J9/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of more than two carbon atoms, e.g. cholane, cholestane, coprostane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB280372A GB1360354A (en) | 1972-01-20 | 1972-01-20 | Chenodeoxycholic acid |
| ES410785A ES410785A1 (es) | 1972-01-20 | 1973-01-19 | Un procedimiento para la purificacion de acido quenodesoxicolico crudo. |
| AU51263/73A AU468382B2 (en) | 1972-01-20 | 1973-01-19 | Chenodeoxycholic acid |
| SE7300810A SE385905B (sv) | 1972-01-20 | 1973-01-19 | Forfarande for rening av chenodeoxicholsyra |
| DE19732302744 DE2302744A1 (de) | 1972-01-20 | 1973-01-20 | Verfahren zur reinigung von roher chenodesoxycholsaeure |
| JP910573A JPS4995955A (enrdf_load_stackoverflow) | 1972-01-20 | 1973-01-20 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB280372A GB1360354A (en) | 1972-01-20 | 1972-01-20 | Chenodeoxycholic acid |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1360354A true GB1360354A (en) | 1974-07-17 |
Family
ID=9746226
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB280372A Expired GB1360354A (en) | 1972-01-20 | 1972-01-20 | Chenodeoxycholic acid |
Country Status (6)
| Country | Link |
|---|---|
| JP (1) | JPS4995955A (enrdf_load_stackoverflow) |
| AU (1) | AU468382B2 (enrdf_load_stackoverflow) |
| DE (1) | DE2302744A1 (enrdf_load_stackoverflow) |
| ES (1) | ES410785A1 (enrdf_load_stackoverflow) |
| GB (1) | GB1360354A (enrdf_load_stackoverflow) |
| SE (1) | SE385905B (enrdf_load_stackoverflow) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2613346C3 (de) * | 1976-03-29 | 1981-07-23 | Diamalt AG, 8000 München | Monoklin kristalline Chenodesoxycholsäure und Verfahren zu ihrer Herstellung |
| FR2521430A1 (fr) * | 1982-02-12 | 1983-08-19 | Pan Medica | Solution aqueuse d'acide ursodesoxycholique a usages therapeutiques, son procede de preparation et application au traitement des lithiases biliaires |
| IL139241A0 (en) | 1998-05-13 | 2001-11-25 | Novo Nordisk As | Meiosis regulating compounds |
| JP2022533069A (ja) * | 2019-05-10 | 2022-07-21 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 腸内細菌胆汁酸代謝の小分子モジュレーター |
-
1972
- 1972-01-20 GB GB280372A patent/GB1360354A/en not_active Expired
-
1973
- 1973-01-19 ES ES410785A patent/ES410785A1/es not_active Expired
- 1973-01-19 AU AU51263/73A patent/AU468382B2/en not_active Expired
- 1973-01-19 SE SE7300810A patent/SE385905B/xx unknown
- 1973-01-20 JP JP910573A patent/JPS4995955A/ja active Pending
- 1973-01-20 DE DE19732302744 patent/DE2302744A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES410785A1 (es) | 1976-04-01 |
| DE2302744A1 (de) | 1973-07-26 |
| AU5126373A (en) | 1974-07-25 |
| SE385905B (sv) | 1976-07-26 |
| JPS4995955A (enrdf_load_stackoverflow) | 1974-09-11 |
| AU468382B2 (en) | 1976-01-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |