GB1359871A - Amino propanol - Google Patents
Amino propanolInfo
- Publication number
- GB1359871A GB1359871A GB4481071A GB4481071A GB1359871A GB 1359871 A GB1359871 A GB 1359871A GB 4481071 A GB4481071 A GB 4481071A GB 4481071 A GB4481071 A GB 4481071A GB 1359871 A GB1359871 A GB 1359871A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- dimethoxyphenyl
- hydrochloride
- propanol
- cycloalkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- MXZROAOUCUVNHX-UHFFFAOYSA-N 2-Aminopropanol Chemical compound CCC(N)O MXZROAOUCUVNHX-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 16
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 7
- 150000001875 compounds Chemical class 0.000 abstract 6
- 125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- -1 methylenedioxy Chemical group 0.000 abstract 4
- XBDQKXXYIPTUBI-UHFFFAOYSA-M Propionate Chemical compound CCC([O-])=O XBDQKXXYIPTUBI-UHFFFAOYSA-M 0.000 abstract 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 229910052799 carbon Inorganic materials 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- NTOIKDYVJIWVSU-UHFFFAOYSA-N 2,3-dihydroxy-2,3-bis(4-methylbenzoyl)butanedioic acid Chemical compound C1=CC(C)=CC=C1C(=O)C(O)(C(O)=O)C(O)(C(O)=O)C(=O)C1=CC=C(C)C=C1 NTOIKDYVJIWVSU-UHFFFAOYSA-N 0.000 abstract 1
- ISIZHKRFAWUAJU-UHFFFAOYSA-N 2-(3,4-dimethoxyphenyl)-3-(propan-2-ylamino)propan-1-ol Chemical compound COC=1C=C(C=CC1OC)C(CO)CNC(C)C ISIZHKRFAWUAJU-UHFFFAOYSA-N 0.000 abstract 1
- PBEFPGHEXMFYHS-UHFFFAOYSA-N 3-(3-cyclopentylpropylamino)-2-(3,4-dimethoxyphenyl)propan-1-ol Chemical compound C1(CCCC1)CCCNCC(CO)C1=CC(=C(C=C1)OC)OC PBEFPGHEXMFYHS-UHFFFAOYSA-N 0.000 abstract 1
- NCYWEWAZPGGTSP-UHFFFAOYSA-N 3-(cyclohexylmethylamino)-2-(3,4-dimethoxyphenyl)propan-1-ol Chemical compound C1(CCCCC1)CNCC(CO)C1=CC(=C(C=C1)OC)OC NCYWEWAZPGGTSP-UHFFFAOYSA-N 0.000 abstract 1
- ZGPHNPBQUPUKDZ-UHFFFAOYSA-N 3-(cyclopentylmethylamino)-2-(3,4-dimethoxyphenyl)propan-1-ol Chemical compound C1(CCCC1)CNCC(CO)C1=CC(=C(C=C1)OC)OC ZGPHNPBQUPUKDZ-UHFFFAOYSA-N 0.000 abstract 1
- LLTMJMRLIPCICJ-UHFFFAOYSA-N 3-amino-2-(3,4-dimethoxyphenyl)propan-1-ol Chemical compound COC1=CC=C(C(CN)CO)C=C1OC LLTMJMRLIPCICJ-UHFFFAOYSA-N 0.000 abstract 1
- FORFWDVUCIXMOM-UHFFFAOYSA-N Cl.C(C1=CC=CC=C1)OC=1C=C(C=CC1OCC1=CC=CC=C1)C(C(=O)OCC)CNCCC1=CC=C(C=C1)OC Chemical compound Cl.C(C1=CC=CC=C1)OC=1C=C(C=CC1OCC1=CC=CC=C1)C(C(=O)OCC)CNCCC1=CC=C(C=C1)OC FORFWDVUCIXMOM-UHFFFAOYSA-N 0.000 abstract 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000001316 cycloalkyl alkyl group Chemical group 0.000 abstract 1
- 125000001033 ether group Chemical group 0.000 abstract 1
- LCHPMKQOJSXOBY-UHFFFAOYSA-N ethyl 2-(3,4-dimethoxyphenyl)-3-(propan-2-ylamino)propanoate Chemical compound C(C)OC(C(CNC(C)C)C1=CC(=C(C=C1)OC)OC)=O LCHPMKQOJSXOBY-UHFFFAOYSA-N 0.000 abstract 1
- IFJIAKXDVJADJE-UHFFFAOYSA-N ethyl 3-(cyclopentylmethylamino)-2-(3,4-dimethoxyphenyl)propanoate Chemical compound C(C)OC(C(CNCC1CCCC1)C1=CC(=C(C=C1)OC)OC)=O IFJIAKXDVJADJE-UHFFFAOYSA-N 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- XTEGVFVZDVNBPF-UHFFFAOYSA-N naphthalene-1,5-disulfonic acid Chemical compound C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1S(O)(=O)=O XTEGVFVZDVNBPF-UHFFFAOYSA-N 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000003884 phenylalkyl group Chemical group 0.000 abstract 1
- 238000002360 preparation method Methods 0.000 abstract 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
- 238000005932 reductive alkylation reaction Methods 0.000 abstract 1
- 230000001975 sympathomimetic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C215/22—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated
- C07C215/28—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings
- C07C215/30—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing six-membered aromatic rings containing hydroxy groups and carbon atoms of six-membered aromatic rings bound to the same carbon atom of the carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1446170A CH534658A (de) | 1970-09-30 | 1970-09-30 | Verfahren zur Herstellung neuer Dihydroxyphenylverbindungen |
| CH1445970A CH535739A (de) | 1970-09-30 | 1970-09-30 | Verfahren zur Herstellung neuer Dihydroxyphenylverbindungen |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1359871A true GB1359871A (en) | 1974-07-10 |
Family
ID=25714500
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB4481071A Expired GB1359871A (en) | 1970-09-30 | 1971-09-27 | Amino propanol |
Country Status (10)
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3888829A (en) * | 1971-06-25 | 1975-06-10 | Sandoz Ag | N,n'-bis(3-hydroxy-2-(3,4-dihydroxy-phenyl)-1-propyl)-aliphatic-diamines |
| JPS5310582B2 (enrdf_load_stackoverflow) * | 1973-04-28 | 1978-04-14 | ||
| US4058642A (en) * | 1973-10-11 | 1977-11-15 | Boehringer Ingelheim Gmbh | 2-Amino-3-(3'-hydroxy-phenyl)-propanols and salts thereof |
| GB1521089A (en) * | 1975-11-12 | 1978-08-09 | Valeas Srl | Aminoethanol derivatives |
| US4220591A (en) * | 1975-11-26 | 1980-09-02 | Commonwealth Scientific And Industrial Research Organization | Insecticidal esters |
| DE3163871D1 (en) | 1980-07-09 | 1984-07-05 | Draco Ab | 1-(dihydroxyphenyl)-2-amino-ethanol derivatives; preparation, compositions and intermediates |
| US4396517A (en) * | 1981-08-10 | 1983-08-02 | Mobil Oil Corporation | Phenolic-containing mannich bases and lubricants containing same |
| US4536601A (en) * | 1982-09-28 | 1985-08-20 | Dainippon Pharmaceutical Co., Ltd. | Optically active N-substituted phenylalaninols and use thereof |
| US4788010A (en) * | 1985-04-24 | 1988-11-29 | E. R. Squibb & Sons, Inc. | Amino substituted benzenepropanols |
| FR2593499B1 (fr) * | 1986-01-30 | 1988-08-12 | Jouveinal Sa | Aminoalcools, leur procede de preparation et leurs applications, notamment en therapeutique |
| US5108363A (en) * | 1988-02-19 | 1992-04-28 | Gensia Pharmaceuticals, Inc. | Diagnosis, evaluation and treatment of coronary artery disease by exercise simulation using closed loop drug delivery of an exercise simulating agent beta agonist |
| FI892341A7 (fi) * | 1988-06-10 | 1989-12-11 | Hoffmann La Roche | Propanoliamiinijohdannaisia |
| IE903957A1 (en) * | 1989-11-06 | 1991-05-08 | Sanofi Sa | Aromatic amine compounds, their method of preparation and¹pharmaceutical compositions in which they are present |
| US5776983A (en) * | 1993-12-21 | 1998-07-07 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| US5770615A (en) * | 1996-04-04 | 1998-06-23 | Bristol-Myers Squibb Company | Catecholamine surrogates useful as β3 agonists |
| UA95641C2 (xx) * | 2006-07-06 | 2011-08-25 | Эррей Биофарма Инк. | Гідроксильовані піримідильні циклопентани як інгібітори акт протеїнкінази$гидроксилированные пиримидильные циклопентаны как ингибиторы акт протеинкиназы |
| US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
-
1971
- 1971-09-21 NL NL7112938A patent/NL7112938A/xx unknown
- 1971-09-24 US US00183633A patent/US3804899A/en not_active Expired - Lifetime
- 1971-09-27 GB GB4481071A patent/GB1359871A/en not_active Expired
- 1971-09-28 ES ES395494A patent/ES395494A1/es not_active Expired
- 1971-09-28 HU HUSA2250A patent/HU162651B/hu unknown
- 1971-09-28 BE BE773204A patent/BE773204A/xx unknown
- 1971-09-29 AU AU34036/71A patent/AU3403671A/en not_active Expired
- 1971-09-29 DE DE19712148551 patent/DE2148551A1/de active Pending
- 1971-09-29 DD DD158025A patent/DD99159A5/xx unknown
- 1971-09-29 FR FR7134986A patent/FR2108100B1/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| HU162651B (enrdf_load_stackoverflow) | 1973-03-28 |
| AU3403671A (en) | 1973-04-05 |
| ES395494A1 (es) | 1974-11-01 |
| DE2148551A1 (de) | 1972-05-10 |
| US3804899A (en) | 1974-04-16 |
| DD99159A5 (enrdf_load_stackoverflow) | 1973-07-20 |
| FR2108100B1 (enrdf_load_stackoverflow) | 1975-04-18 |
| BE773204A (fr) | 1972-03-28 |
| NL7112938A (enrdf_load_stackoverflow) | 1972-04-05 |
| FR2108100A1 (enrdf_load_stackoverflow) | 1972-05-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PLNP | Patent lapsed through nonpayment of renewal fees |