GB1351437A - N-substituted amino acids having antiviral anti-inflammatory or anti-tumour activity - Google Patents
N-substituted amino acids having antiviral anti-inflammatory or anti-tumour activityInfo
- Publication number
- GB1351437A GB1351437A GB3874872A GB3874872A GB1351437A GB 1351437 A GB1351437 A GB 1351437A GB 3874872 A GB3874872 A GB 3874872A GB 3874872 A GB3874872 A GB 3874872A GB 1351437 A GB1351437 A GB 1351437A
- Authority
- GB
- United Kingdom
- Prior art keywords
- inflammatory
- amino acids
- naphthylaminomethyl
- isoleucine
- phenylalanine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 230000000259 anti-tumor effect Effects 0.000 title abstract 2
- -1 N-substituted amino Chemical class 0.000 title 1
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 230000000840 anti-viral effect Effects 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 239000004480 active ingredient Substances 0.000 abstract 2
- 239000003937 drug carrier Substances 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 230000001225 therapeutic effect Effects 0.000 abstract 2
- JYNQODMBEJIBPV-NRFANRHFSA-N (2S)-2-(9H-fluoren-2-ylsulfonylamino)-3-phenylpropanoic acid Chemical compound C1=C(C=CC=2C3=CC=CC=C3CC12)S(=O)(=O)N[C@@H](CC1=CC=CC=C1)C(=O)O JYNQODMBEJIBPV-NRFANRHFSA-N 0.000 abstract 1
- UTPGCGRYVHXMIX-KRWDZBQOSA-N (2S)-2-(9H-fluoren-2-ylsulfonylamino)-4-methylsulfanylbutanoic acid Chemical compound C1=C(C=CC=2C3=CC=CC=C3CC12)S(=O)(=O)N[C@@H](CCSC)C(=O)O UTPGCGRYVHXMIX-KRWDZBQOSA-N 0.000 abstract 1
- WUOYTRYHVYGCTB-ZDUSSCGKSA-N (2S)-2-(furan-2-ylmethylamino)-3-(4-nitrophenyl)propanoic acid Chemical compound C(C1=CC=CO1)N[C@@H](CC1=CC=C(C=C1)[N+](=O)[O-])C(=O)O WUOYTRYHVYGCTB-ZDUSSCGKSA-N 0.000 abstract 1
- FJBAOZHBRMLMCP-NSHDSACASA-N (2s)-2-(benzylazaniumyl)-3-methylbutanoate Chemical compound CC(C)[C@@H](C(O)=O)NCC1=CC=CC=C1 FJBAOZHBRMLMCP-NSHDSACASA-N 0.000 abstract 1
- WZSGFIUEVNGAHS-AWEZNQCLSA-N (2s)-2-[(furan-2-ylmethylamino)methylamino]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)NCNCC=1OC=CC=1)C1=CC=CC=C1 WZSGFIUEVNGAHS-AWEZNQCLSA-N 0.000 abstract 1
- FSHHRPYYOVIVLW-QFIPXVFZSA-N (2s)-2-[[2-(9h-fluoren-9-yl)acetyl]amino]-3-phenylpropanoic acid Chemical compound C([C@@H](C(=O)O)NC(=O)CC1C2=CC=CC=C2C2=CC=CC=C21)C1=CC=CC=C1 FSHHRPYYOVIVLW-QFIPXVFZSA-N 0.000 abstract 1
- ONFCFBRYSUZTJY-ZETCQYMHSA-N (2s)-3-methyl-2-(propanoylamino)butanoic acid Chemical compound CCC(=O)N[C@@H](C(C)C)C(O)=O ONFCFBRYSUZTJY-ZETCQYMHSA-N 0.000 abstract 1
- LWMMDGGPZGXAJP-HKUYNNGSSA-N (2s,3s)-3-methyl-2-(tetradecanoylamino)pentanoic acid Chemical compound CCCCCCCCCCCCCC(=O)N[C@H](C(O)=O)[C@@H](C)CC LWMMDGGPZGXAJP-HKUYNNGSSA-N 0.000 abstract 1
- CDOCNWRWMUMCLP-UHFFFAOYSA-N 2-(dodecanoylamino)-4-methylpentanoic acid Chemical compound CCCCCCCCCCCC(=O)NC(C(O)=O)CC(C)C CDOCNWRWMUMCLP-UHFFFAOYSA-N 0.000 abstract 1
- JOYRKODLDBILNP-UHFFFAOYSA-N Ethyl urethane Chemical compound CCOC(N)=O JOYRKODLDBILNP-UHFFFAOYSA-N 0.000 abstract 1
- 239000004473 Threonine Substances 0.000 abstract 1
- 150000003862 amino acid derivatives Chemical class 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000002552 dosage form Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229940079593 drug Drugs 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 229960000310 isoleucine Drugs 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 241000712461 unidentified influenza virus Species 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C271/06—Esters of carbamic acids
- C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
- C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D307/52—Radicals substituted by nitrogen atoms not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/02—Ortho- or ortho- and peri-condensed systems
- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/10—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings
- C07C2603/12—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing five-membered rings only one five-membered ring
- C07C2603/18—Fluorenes; Hydrogenated fluorenes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP6325071A JPS5218176B2 (enrdf_load_stackoverflow) | 1971-08-19 | 1971-08-19 | |
| JP6325271A JPS4828612A (enrdf_load_stackoverflow) | 1971-08-19 | 1971-08-19 | |
| JP6325171A JPS5313626B2 (enrdf_load_stackoverflow) | 1971-08-19 | 1971-08-19 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1351437A true GB1351437A (en) | 1974-05-01 |
Family
ID=27298102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3874872A Expired GB1351437A (en) | 1971-08-19 | 1972-08-10 | N-substituted amino acids having antiviral anti-inflammatory or anti-tumour activity |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE2236876C3 (enrdf_load_stackoverflow) |
| FR (1) | FR2150803B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1351437A (enrdf_load_stackoverflow) |
| NL (1) | NL7211361A (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416820A (en) | 1981-01-14 | 1983-11-22 | Takeda Chemical Industries, Ltd. | Indole derivatives and a method for production of peptides |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2508444A1 (fr) * | 1981-06-29 | 1982-12-31 | Irceba | Nouveaux derives sulfonyle du tryptophane utiles en tant que medicaments et leur procede de preparation |
| WO1998009957A1 (en) * | 1996-09-04 | 1998-03-12 | Warner-Lambert Company | Compounds for and a method of inhibiting matrix metalloproteinases |
| CA2332961A1 (en) * | 1998-05-21 | 1999-11-25 | Michael Zasloff | A method for stimulation of defensin production by exposure to isoleucine |
| DE10112882A1 (de) * | 2001-03-15 | 2002-09-19 | Max Delbrueck Centrum | Verwendung von Tryptophan-Derivaten zur spezifischen zytostatischen Behandlung von Serotonin-produzierenden Tumoren |
| DE10321759B4 (de) * | 2003-05-15 | 2006-04-27 | Henkel Kgaa | Verfahren zur Sprühtrocknung rieselfähiger Wertstoffe |
-
1972
- 1972-07-27 DE DE2236876A patent/DE2236876C3/de not_active Expired
- 1972-08-10 GB GB3874872A patent/GB1351437A/en not_active Expired
- 1972-08-18 FR FR7229667A patent/FR2150803B1/fr not_active Expired
- 1972-08-18 NL NL7211361A patent/NL7211361A/xx not_active Application Discontinuation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4416820A (en) | 1981-01-14 | 1983-11-22 | Takeda Chemical Industries, Ltd. | Indole derivatives and a method for production of peptides |
Also Published As
| Publication number | Publication date |
|---|---|
| DE2236876B2 (de) | 1980-06-04 |
| FR2150803A1 (enrdf_load_stackoverflow) | 1973-04-13 |
| FR2150803B1 (enrdf_load_stackoverflow) | 1975-10-17 |
| NL7211361A (enrdf_load_stackoverflow) | 1973-02-21 |
| DE2236876A1 (de) | 1973-03-01 |
| DE2236876C3 (de) | 1981-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |