GB1340531A - Preparation of substituted chromenols - Google Patents

Preparation of substituted chromenols

Info

Publication number
GB1340531A
GB1340531A GB1340531DA GB1340531A GB 1340531 A GB1340531 A GB 1340531A GB 1340531D A GB1340531D A GB 1340531DA GB 1340531 A GB1340531 A GB 1340531A
Authority
GB
United Kingdom
Prior art keywords
chromenols
substituted
group
chromenol
hexyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of GB1340531A publication Critical patent/GB1340531A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1340531 Heterocyclic-substituted chromenols BEECHAM GROUP Ltd 12 Jan 1972 [28 Jan 1971] 3354/71 Heading C2C A chromenol of Formula (I) or a salt thereof wherein R 1 is a C 1-20 hydrocarbon group, R 2 is a 6-membered heterocyclic group, with a nitrogen atom in the 4-position, R 3 a C 1-6 alkyl group, is obtained by reacting coumarin of Formula (II) with an alkali lithium compound R 3 Li and, if any intermediate triol (IV) is formed converting it, with or without isolation, by reaction with an acid to the chromenol (I), and if desired, forming a salt. Intermediate (II), in which R 2 is 4-pyridyl, Y is OH, and R 1 is n-butyl, n-hexyl, 2-hexyl or 2-heptyl, are obtained by reacting a mixture of ethyl iso-nicotinoylacetate and 5-(R 1 )-3,5-dihydroxy benzene with conc. sulphuric acid and/or phosphoryl chloride.
GB1340531D 1971-01-28 1971-01-28 Preparation of substituted chromenols Expired GB1340531A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB335471 1971-01-28

Publications (1)

Publication Number Publication Date
GB1340531A true GB1340531A (en) 1973-12-12

Family

ID=9756735

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1340531D Expired GB1340531A (en) 1971-01-28 1971-01-28 Preparation of substituted chromenols

Country Status (4)

Country Link
CA (1) CA981682A (en)
CH (1) CH577501A5 (en)
ES (1) ES399221A1 (en)
GB (1) GB1340531A (en)

Also Published As

Publication number Publication date
ES399221A1 (en) 1974-11-16
CH577501A5 (en) 1976-07-15
CA981682A (en) 1976-01-13

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee