GB1337737A - Benzodiazepine derivatives - Google Patents
Benzodiazepine derivativesInfo
- Publication number
- GB1337737A GB1337737A GB2860172A GB1337737DA GB1337737A GB 1337737 A GB1337737 A GB 1337737A GB 2860172 A GB2860172 A GB 2860172A GB 1337737D A GB1337737D A GB 1337737DA GB 1337737 A GB1337737 A GB 1337737A
- Authority
- GB
- United Kingdom
- Prior art keywords
- nov
- alkyl
- prepared
- acid ester
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title abstract 3
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title abstract 2
- -1 isocyanic acid ester Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 abstract 1
- YPXQSGWOGQPLQO-UHFFFAOYSA-N 5-nitro-1,3-dihydrobenzimidazole-2-thione Chemical group [O-][N+](=O)C1=CC=C2N=C(S)NC2=C1 YPXQSGWOGQPLQO-UHFFFAOYSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- XLJMAIOERFSOGZ-UHFFFAOYSA-N anhydrous cyanic acid Natural products OC#N XLJMAIOERFSOGZ-UHFFFAOYSA-N 0.000 abstract 1
- 230000001773 anti-convulsant effect Effects 0.000 abstract 1
- 239000001961 anticonvulsive agent Substances 0.000 abstract 1
- 229960003965 antiepileptics Drugs 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229940049706 benzodiazepine Drugs 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 abstract 1
- 125000000717 hydrazino group Chemical group [H]N([*])N([H])[H] 0.000 abstract 1
- 125000001183 hydrocarbyl group Chemical group 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- ZMZDMBWJUHKJPS-UHFFFAOYSA-N hydrogen thiocyanate Natural products SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 abstract 1
- 230000001939 inductive effect Effects 0.000 abstract 1
- 210000003205 muscle Anatomy 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 230000002040 relaxant effect Effects 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 230000001624 sedative effect Effects 0.000 abstract 1
- 125000001439 semicarbazido group Chemical group [H]N([H])C(=O)N([H])N([H])* 0.000 abstract 1
- 230000007958 sleep Effects 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
- C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
- C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
- C07D243/20—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP44092366A JPS4910958B1 (enrdf_load_stackoverflow) | 1969-11-18 | 1969-11-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1337737A true GB1337737A (en) | 1973-11-21 |
Family
ID=14052400
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5479770A Expired GB1337736A (en) | 1969-11-18 | 1970-11-18 | Benzodiazepine derivatives |
| GB2860172A Expired GB1337737A (en) | 1969-11-18 | 1970-11-18 | Benzodiazepine derivatives |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB5479770A Expired GB1337736A (en) | 1969-11-18 | 1970-11-18 | Benzodiazepine derivatives |
Country Status (15)
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA713364B (en) * | 1970-06-18 | 1972-01-26 | Upjohn Co | Prganic compounds and process |
| JPS494470B1 (enrdf_load_stackoverflow) * | 1970-08-26 | 1974-02-01 | ||
| CH545302A (de) * | 1971-04-08 | 1974-01-13 | Ciba Geigy Ag | Verfahren zur Herstellung von neuen Triazolo-benzodiazepinderivaten |
| US3751426A (en) * | 1971-04-28 | 1973-08-07 | Upjohn Co | 1-substituted-6-phenyl-4h-s-triazolo(4,3-a)(1,6)benzodiazepine compounds |
| GB1377230A (en) * | 1971-09-13 | 1974-12-11 | Upjohn Co | 4h-s-triazolo -4,3-a- 1,4-benzodiazepines |
| BE790356A (fr) * | 1971-10-21 | 1973-04-20 | Takeda Chemical Industries Ltd | Derives de benzodiazepine |
| JPS5418280B2 (enrdf_load_stackoverflow) * | 1971-10-30 | 1979-07-06 | ||
| BE793629A (fr) * | 1972-01-03 | 1973-07-03 | Upjohn Co | Nouveaux derives de benzodiazepines et leur preparation |
| DE3021107A1 (de) * | 1980-06-04 | 1981-12-17 | Hoechst Ag, 6000 Frankfurt | Carbamoyloxyamino-1,4-benzodiazepine, verfahren zu irer herstellung und diese enthaltende arzneimittel |
| CA1211437A (en) * | 1981-08-12 | 1986-09-16 | Rene Borer | Benzazepines |
| CN111533745A (zh) * | 2020-05-20 | 2020-08-14 | 成都药明康德新药开发有限公司 | 叔丁基-3-(氨基甲基)二氢-5h-三唑并二氮杂卓-8(9h)-甲酸基酯制法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI50981C (fi) * | 1968-11-05 | 1976-09-10 | Takeda Chemical Industries Ltd | Menetelmä unilääkkeinä ja rauhoittavina lääkkeinä vaikuttavien s-triat solo-(4,3-a)(1,4)-bentsodiatsepiinien valmistamiseksi. |
| US3987052A (en) * | 1969-03-17 | 1976-10-19 | The Upjohn Company | 6-Phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines |
-
0
- BE BE759099D patent/BE759099A/xx not_active IP Right Cessation
-
1969
- 1969-11-17 JP JP44092336A patent/JPS5010659B1/ja active Pending
- 1969-11-18 JP JP44092366A patent/JPS4910958B1/ja active Pending
-
1970
- 1970-11-11 ZA ZA707644A patent/ZA707644B/xx unknown
- 1970-11-13 NO NO4341/70A patent/NO126085B/no unknown
- 1970-11-14 DE DE19702064926 patent/DE2064926A1/de active Pending
- 1970-11-14 DE DE19702056174 patent/DE2056174A1/de active Pending
- 1970-11-17 DK DK582970AA patent/DK141846B/da unknown
- 1970-11-17 ES ES385641A patent/ES385641A1/es not_active Expired
- 1970-11-17 FR FR7041215A patent/FR2073379B1/fr not_active Expired
- 1970-11-17 NL NL7016848A patent/NL167697C/xx not_active IP Right Cessation
- 1970-11-18 CH CH1708170A patent/CH551432A/xx not_active IP Right Cessation
- 1970-11-18 CH CH1060273A patent/CH549588A/xx not_active IP Right Cessation
- 1970-11-18 GB GB5479770A patent/GB1337736A/en not_active Expired
- 1970-11-18 YU YU2827/70A patent/YU34898B/xx unknown
- 1970-11-18 SE SE15638/70A patent/SE363111B/xx unknown
- 1970-11-18 FI FI703096A patent/FI51701C/fi active
- 1970-11-18 AT AT1038070A patent/AT300816B/de not_active IP Right Cessation
- 1970-11-18 AT AT995571A patent/AT311993B/de not_active IP Right Cessation
- 1970-11-18 GB GB2860172A patent/GB1337737A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FI51701B (enrdf_load_stackoverflow) | 1976-11-30 |
| ES385641A1 (es) | 1973-10-01 |
| DK141846B (da) | 1980-06-30 |
| SE363111B (enrdf_load_stackoverflow) | 1974-01-07 |
| DE2056174A1 (de) | 1971-06-24 |
| NO126085B (enrdf_load_stackoverflow) | 1972-12-18 |
| JPS4910958B1 (enrdf_load_stackoverflow) | 1974-03-13 |
| ZA707644B (en) | 1971-08-25 |
| AT300816B (de) | 1972-08-10 |
| GB1337736A (en) | 1973-11-21 |
| YU34898B (en) | 1980-04-30 |
| BE759099A (fr) | 1971-04-30 |
| FI51701C (fi) | 1977-03-10 |
| AT311993B (de) | 1973-12-10 |
| CH549588A (de) | 1974-05-31 |
| JPS5010659B1 (enrdf_load_stackoverflow) | 1975-04-23 |
| NL167697C (nl) | 1982-01-18 |
| FR2073379A1 (enrdf_load_stackoverflow) | 1971-10-01 |
| YU282770A (en) | 1979-10-31 |
| FR2073379B1 (enrdf_load_stackoverflow) | 1974-08-23 |
| NL167697B (nl) | 1981-08-17 |
| NL7016848A (enrdf_load_stackoverflow) | 1971-05-21 |
| DK141846C (enrdf_load_stackoverflow) | 1980-11-24 |
| CH551432A (de) | 1974-07-15 |
| DE2064926A1 (de) | 1971-07-22 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |