GB1327157A - N-acyl-piperazinoalkyl-pyrazoles and their preparation - Google Patents
N-acyl-piperazinoalkyl-pyrazoles and their preparationInfo
- Publication number
- GB1327157A GB1327157A GB411272A GB411272A GB1327157A GB 1327157 A GB1327157 A GB 1327157A GB 411272 A GB411272 A GB 411272A GB 411272 A GB411272 A GB 411272A GB 1327157 A GB1327157 A GB 1327157A
- Authority
- GB
- United Kingdom
- Prior art keywords
- general formula
- group
- piperazinoalkyl
- acyl
- pyrazoles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 239000012458 free base Substances 0.000 abstract 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 2
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 abstract 1
- 208000010513 Stupor Diseases 0.000 abstract 1
- 239000004480 active ingredient Substances 0.000 abstract 1
- 125000001931 aliphatic group Chemical group 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 238000006243 chemical reaction Methods 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000005843 halogen group Chemical group 0.000 abstract 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000000701 neuroleptic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
- C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
- C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19712110568 DE2110568A1 (de) | 1971-03-05 | 1971-03-05 | Neue N-Acyl-(piperazinoalkyl)-pyrazole |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1327157A true GB1327157A (en) | 1973-08-15 |
Family
ID=5800618
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB411272A Expired GB1327157A (en) | 1971-03-05 | 1972-01-28 | N-acyl-piperazinoalkyl-pyrazoles and their preparation |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US3839336A (enExample) |
| AT (1) | AT317886B (enExample) |
| AU (1) | AU456680B2 (enExample) |
| BE (1) | BE779976A (enExample) |
| CA (1) | CA1006522A (enExample) |
| CH (1) | CH574440A5 (enExample) |
| CS (1) | CS162771B2 (enExample) |
| DD (1) | DD95383A5 (enExample) |
| DE (1) | DE2110568A1 (enExample) |
| DK (1) | DK129794B (enExample) |
| ES (1) | ES400453A1 (enExample) |
| FR (1) | FR2128592B1 (enExample) |
| GB (1) | GB1327157A (enExample) |
| HU (1) | HU164091B (enExample) |
| IL (1) | IL38650A (enExample) |
| NL (1) | NL7202242A (enExample) |
| SE (1) | SE386897B (enExample) |
| ZA (1) | ZA72505B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1248531A (en) * | 1984-04-17 | 1989-01-10 | Jeffrey C. Watkins | 4-substituted piperazine-2-carboxylic acids |
| US4562189A (en) * | 1984-10-09 | 1985-12-31 | American Cyanamid Company | Pyrazolylpiperazines |
| DE4425146A1 (de) * | 1994-07-15 | 1996-01-18 | Basf Ag | Verwendung heterocyclischer Verbindungen |
| DE19728996A1 (de) | 1997-07-07 | 1999-01-14 | Basf Ag | Triazolverbindungen und deren Verwendung |
| WO2020163689A1 (en) | 2019-02-08 | 2020-08-13 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | 20-hete formation inhibitors |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3308130A (en) * | 1962-04-26 | 1967-03-07 | Du Pont | N-disubstituted carbamyl pyrazoles |
| US3224217A (en) * | 1963-07-25 | 1965-12-21 | Cyclops Inc | Refrigerating system including an accumulator |
| DE1595920B2 (de) * | 1964-11-04 | 1978-08-10 | Merck Patent Gmbh, 6100 Darmstadt | 4-(co-Piperazinoalkyl)-pyrazole, ihre Salze und Verfahren zu ihrer Herstellung |
| DE1595958A1 (de) * | 1965-09-30 | 1970-06-11 | Merck Anlagen Gmbh | 4-(omega-Piperazinoalkyl)-pyrazole,ihre Salze und Verfahren zu ihrer Herstellung |
| FR1510206A (fr) * | 1965-12-23 | 1968-01-19 | Ciba Geigy | Procédé de préparation de diaza-cyclo-alcanes substitués |
| DE1620016C3 (de) * | 1966-07-02 | 1979-08-30 | Merck Patent Gmbh, 6100 Darmstadt | 3-{Piperazinoalkyl)-pyrazole und Verfahren zu ihrer Herstellung |
| DE1242045B (de) * | 1966-08-20 | 1967-06-08 | Daimler Benz Ag | Ventilsteuerung fuer eine Kolbenbrennkraftmaschine |
| DE1795314A1 (de) * | 1968-09-11 | 1972-01-05 | Merck Patent Gmbh | N-(Thiazolyl-2)-piperazine |
-
1971
- 1971-03-05 DE DE19712110568 patent/DE2110568A1/de active Pending
- 1971-12-31 DD DD160107A patent/DD95383A5/xx unknown
- 1971-12-31 CS CS9179A patent/CS162771B2/cs unknown
-
1972
- 1972-01-25 ZA ZA720505A patent/ZA72505B/xx unknown
- 1972-01-26 IL IL38650A patent/IL38650A/en unknown
- 1972-01-28 GB GB411272A patent/GB1327157A/en not_active Expired
- 1972-02-02 AU AU38556/72A patent/AU456680B2/en not_active Expired
- 1972-02-15 CH CH213072A patent/CH574440A5/xx not_active IP Right Cessation
- 1972-02-21 NL NL7202242A patent/NL7202242A/xx unknown
- 1972-02-29 SE SE7202515A patent/SE386897B/xx unknown
- 1972-02-29 BE BE779976A patent/BE779976A/xx unknown
- 1972-03-03 HU HUME1473A patent/HU164091B/hu unknown
- 1972-03-03 DK DK100572AA patent/DK129794B/da unknown
- 1972-03-03 FR FR7207488A patent/FR2128592B1/fr not_active Expired
- 1972-03-03 AT AT181872A patent/AT317886B/de active
- 1972-03-03 US US00231750A patent/US3839336A/en not_active Expired - Lifetime
- 1972-03-03 CA CA136,195A patent/CA1006522A/en not_active Expired
- 1972-03-04 ES ES400453A patent/ES400453A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| CA1006522A (en) | 1977-03-08 |
| DD95383A5 (enExample) | 1973-02-05 |
| NL7202242A (enExample) | 1972-09-07 |
| IL38650A (en) | 1976-03-31 |
| DK129794B (da) | 1974-11-18 |
| BE779976A (fr) | 1972-08-29 |
| CS162771B2 (enExample) | 1975-07-15 |
| FR2128592B1 (enExample) | 1975-08-01 |
| DK129794C (enExample) | 1975-04-28 |
| US3839336A (en) | 1974-10-01 |
| ZA72505B (en) | 1972-10-25 |
| DE2110568A1 (de) | 1972-09-07 |
| AU456680B2 (en) | 1974-12-09 |
| FR2128592A1 (enExample) | 1972-10-20 |
| SE386897B (sv) | 1976-08-23 |
| CH574440A5 (enExample) | 1976-04-15 |
| ES400453A1 (es) | 1975-06-16 |
| HU164091B (enExample) | 1973-12-28 |
| AU3855672A (en) | 1973-08-09 |
| IL38650A0 (en) | 1972-03-28 |
| AT317886B (de) | 1974-09-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |