GB1321917A - Method and apparatus for optical analysis of the contents of a sheathed stream - Google Patents

Method and apparatus for optical analysis of the contents of a sheathed stream

Info

Publication number
GB1321917A
GB1321917A GB3851971A GB3851971A GB1321917A GB 1321917 A GB1321917 A GB 1321917A GB 3851971 A GB3851971 A GB 3851971A GB 3851971 A GB3851971 A GB 3851971A GB 1321917 A GB1321917 A GB 1321917A
Authority
GB
United Kingdom
Prior art keywords
stream
sheathing
liquid
restriction
sample
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3851971A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Corp
Original Assignee
Technicon Instruments Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Technicon Instruments Corp filed Critical Technicon Instruments Corp
Publication of GB1321917A publication Critical patent/GB1321917A/en
Expired legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/1404—Handling flow, e.g. hydrodynamic focusing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells

Landscapes

  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Optical Measuring Cells (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)

Abstract

1321917 Photo-electric analysis TECHMCON INSTRUMENTS CORP 17 Aug 1971 [28 Aug 1970] 38519/71 Heading G1A [Also in Division G2] Optical apparatus for analysis of a liquid sample stream, e.g. a suspension of particles in a liquid, entrained co-axially by a sheathing stream has a restriction 42 through which the streams pass, and photo-metric means 25, 26 arranged downstream of the restriction. As shown, sheathing liquid is fed in at 31, and the sample stream at 38. The tube after restriction may be flattened Fig. 3, (not shown) Alternatively, the restricted stream may be projected into a gas, e.g. air, between a lightsource and detector Fig. 5, (not shown). The sample and sheathing streams may be horizontally or vertically directed, and inlets 31 may be at other than 90 degrees to the direction of the sample stream. Sheathing liquid may be provided from a constantlevel reservoir, and the sheathed stream pulled through by a vacuum pump Fig. 1, (not shown).
GB3851971A 1970-08-28 1971-08-17 Method and apparatus for optical analysis of the contents of a sheathed stream Expired GB1321917A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6781970A 1970-08-28 1970-08-28

Publications (1)

Publication Number Publication Date
GB1321917A true GB1321917A (en) 1973-07-04

Family

ID=22078614

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3851971A Expired GB1321917A (en) 1970-08-28 1971-08-17 Method and apparatus for optical analysis of the contents of a sheathed stream

Country Status (9)

Country Link
US (1) US3661460A (en)
AU (1) AU445066B2 (en)
BE (1) BE770541A (en)
CA (1) CA936017A (en)
CH (1) CH552807A (en)
DE (1) DE2142237C3 (en)
FR (1) FR2106060A5 (en)
GB (1) GB1321917A (en)
NL (1) NL7111164A (en)

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GB2122369A (en) * 1982-04-29 1984-01-11 Int Remote Imaging Systems Inc A method of separating particles in a moving fluid sample
GB2172713A (en) * 1985-03-22 1986-09-24 Philips Nv Spectrometer having variable flow sample feed

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US3861800A (en) * 1972-07-27 1975-01-21 Becton Dickinson Co Particle counter independent of flow rate
US3871770A (en) * 1973-06-04 1975-03-18 Nuclear Data Inc Hydrodynamic focusing method and apparatus
USRE29141E (en) * 1973-06-14 1977-02-22 Coulter Electronics, Inc. Apparatus for orienting generally flat particles for sensing
US3893766A (en) * 1973-06-14 1975-07-08 Coulter Electronics Apparatus for orienting generally flat particles for slit-scan photometry
DE2543310C2 (en) * 1975-09-27 1982-04-29 Gesellschaft für Strahlen- und Umweltforschung mbH, 8000 München Device for counting and classifying particles suspended in a liquid
US4408877A (en) * 1979-04-10 1983-10-11 Ernst Leitz Wetzlar Gmbh Device for hydrodynamic focussing of a particle-suspension in a liquid flow cytophotometer
NO144002C (en) * 1979-04-10 1981-05-27 Norsk Hydro S Inst For Kreftfo DEVICE FOR USE IN LIQUID PHOTOMETRY
US4284412A (en) * 1979-07-13 1981-08-18 Ortho Diagnostics, Inc. Method and apparatus for automated identification and enumeration of specified blood cell subclasses
DE2934691C2 (en) * 1979-08-28 1988-06-16 Fresenius AG, 6380 Bad Homburg Method for carrying out analyzes using the flow method and measuring device therefor
EP0046345A3 (en) * 1980-08-15 1982-03-03 Ortho Diagnostic Systems Inc. Controlled hydrodynamic flow in flow cytometry systems
US4447883A (en) * 1981-05-26 1984-05-08 Technicon Instruments Corporation Coincidence-error correcting apparatus and method
CA1194315A (en) * 1982-08-16 1985-10-01 Technicon Instruments Corporation Volumetric pumping apparatus and method for supplying fluids to sheath stream flow cells
US4683212A (en) * 1982-09-30 1987-07-28 Technicon Instruments Corporation Random access single channel sheath stream apparatus
US4565448A (en) * 1983-03-11 1986-01-21 E. I. Du Pont De Nemours And Company Particle counting apparatus
DE3477966D1 (en) * 1983-05-12 1989-06-01 Toshiba Kk Grain counter
JPH0336914Y2 (en) * 1985-05-17 1991-08-05
EP0286088B1 (en) * 1987-04-08 1994-09-14 Hitachi, Ltd. A sheath flow type flow-cell device
US4971912A (en) * 1987-07-14 1990-11-20 Technicon Instruments Corporation Apparatus and method for the separation of immiscible liquids
DE3820902A1 (en) * 1988-06-21 1989-12-28 Basf Ag ARRANGEMENT FOR MEASURING THE DEGREE OF DISPERSION IN FLOWING SUSPENSIONS
JPH0718785B2 (en) * 1988-09-19 1995-03-06 株式会社日立製作所 Flow cell device
US5194909A (en) * 1990-12-04 1993-03-16 Tycko Daniel H Apparatus and method for measuring volume and hemoglobin concentration of red blood cells
US5370842A (en) * 1991-11-29 1994-12-06 Canon Kabushiki Kaisha Sample measuring device and sample measuring system
GB9405028D0 (en) * 1994-03-15 1994-04-27 Counting Tech Ltd Fluid diluter
US5643796A (en) * 1994-10-14 1997-07-01 University Of Washington System for sensing droplet formation time delay in a flow cytometer
US5602349A (en) * 1994-10-14 1997-02-11 The University Of Washington Sample introduction system for a flow cytometer
US6861265B1 (en) 1994-10-14 2005-03-01 University Of Washington Flow cytometer droplet formation system
US5602039A (en) * 1994-10-14 1997-02-11 The University Of Washington Flow cytometer jet monitor system
EP0786078B1 (en) * 1994-10-14 2004-01-07 University of Washington System and method for high speed flow cytometer droplet formation
US5593564A (en) * 1995-07-24 1997-01-14 Hewlett-Packard Company Microcolumn-microcolumn flow interface and method
JP4323571B2 (en) 1997-01-31 2009-09-02 エックスワイ， インコーポレイテッド Optical device
US5819948A (en) * 1997-08-21 1998-10-13 Van Den Engh; Gerrit J. Particle separating apparatus and method
US6149867A (en) 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
BR9912539A (en) 1998-07-30 2001-05-02 Xy Inc Equine system for non-surgical artificial insemination
US6507400B1 (en) 1999-02-27 2003-01-14 Mwi, Inc. Optical system for multi-part differential particle discrimination and an apparatus using the same
US7024316B1 (en) * 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US7208265B1 (en) 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
US6263745B1 (en) * 1999-12-03 2001-07-24 Xy, Inc. Flow cytometer nozzle and flow cytometer sample handling methods
US6646742B1 (en) 2000-02-19 2003-11-11 Mwi, Inc. Optical device and method for multi-angle laser light scatter
EP2258172B1 (en) * 2000-05-09 2017-04-19 Xy, Llc Flow cytometer for diffentiating x-chromosome bearing and y-chromosome bearing populations of spermatozoa
US7242474B2 (en) * 2004-07-27 2007-07-10 Cox James A Cytometer having fluid core stream position control
HUP0303158A2 (en) * 2000-06-12 2003-12-29 Colorado State University Integrated herd management system utilizing isolated populations of x-chromosome bearing and y-chromosome bearing spermatozoa
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
CA2822983C (en) 2000-11-29 2017-05-09 Xy, Llc System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
ES2405320T3 (en) 2001-05-17 2013-05-30 Beckman Coulter, Inc. Flow cytometer with an active automated optical alienation system
US20030211009A1 (en) * 2001-05-18 2003-11-13 Buchanan Kris S. Rapid multi-material sample input system
EP1348943A3 (en) 2002-03-25 2003-12-17 Sysmex Corporation Sheath liquid for particle analyzer
US11243494B2 (en) 2002-07-31 2022-02-08 Abs Global, Inc. Multiple laminar flow-based particle and cellular separation with laser steering
JP4595067B2 (en) 2002-08-01 2010-12-08 エックスワイ，エルエルシー Low-pressure sperm cell separation system
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CN100570360C (en) 2002-08-15 2009-12-16 Xy公司 A kind of flow cytometer and flow cytometry method
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
DK2305171T3 (en) 2003-03-28 2022-03-21 Inguran Llc Apparatus and methods for providing sexed animal semen
ES2541121T3 (en) 2003-05-15 2015-07-16 Xy, Llc Efficient classification of haploid cells by flow cytometry systems
US7892725B2 (en) 2004-03-29 2011-02-22 Inguran, Llc Process for storing a sperm dispersion
US7256882B2 (en) * 2004-06-21 2007-08-14 Bgi Instruments, Inc. Photometer device and method
AU2005266930B2 (en) 2004-07-22 2010-09-16 Inguran, Llc Process for enriching a population of sperm cells
DK2884258T3 (en) 2004-07-27 2017-01-02 Beckman Coulter Inc IMPROVING FLOW CYTOMETRIC DISCRIMINATION WITH COMPUTER IMPLEMENTED GEOMETRIC TRANSFORMATION
US7618770B2 (en) * 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
US10908066B2 (en) 2010-11-16 2021-02-02 1087 Systems, Inc. Use of vibrational spectroscopy for microfluidic liquid measurement
JP5852834B2 (en) * 2011-10-04 2016-02-03 アズビル株式会社 Evaluation system for particle detector and evaluation method for particle detector
US9746412B2 (en) 2012-05-30 2017-08-29 Iris International, Inc. Flow cytometer
US8961904B2 (en) 2013-07-16 2015-02-24 Premium Genetics (Uk) Ltd. Microfluidic chip
US11796449B2 (en) 2013-10-30 2023-10-24 Abs Global, Inc. Microfluidic system and method with focused energy apparatus
WO2015063552A2 (en) 2013-10-30 2015-05-07 Premium Genetics (Uk) Ltd. Microfluidic system and method with focused energy apparatus
JP2018509615A (en) 2015-02-19 2018-04-05 プレミアム ジェネティクス （ユーケー） リミテッド Scanning infrared measurement system
BR112020023607A2 (en) 2018-05-23 2021-02-17 Abs Global, Inc. systems and methods for focusing particles on microchannels
EP3955735B1 (en) 2019-04-18 2024-05-22 ABS Global, Inc. System and process for continuous addition of cryoprotectant
US11628439B2 (en) 2020-01-13 2023-04-18 Abs Global, Inc. Single-sheath microfluidic chip

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US2731877A (en) * 1956-01-24 clamann
US2732753A (en) * 1956-01-31 o konski
US2875666A (en) * 1953-07-13 1959-03-03 Ohio Commw Eng Co Method of simultaneously counting red and white blood cells
US2920525A (en) * 1956-08-13 1960-01-12 Arthur V Appel Apparatus for automatically counting and sizing airborne particles
NL132814C (en) * 1963-07-24
US3560754A (en) * 1965-11-17 1971-02-02 Ibm Photoelectric particle separator using time delay
US3523733A (en) * 1966-01-05 1970-08-11 Technicon Corp Method and apparatus for particle counting
US3440866A (en) * 1966-09-01 1969-04-29 Research Corp Prothrombin timer apparatus and method
US3504183A (en) * 1966-09-12 1970-03-31 Iit Res Inst Particle counter using a variable test volume
US3515884A (en) * 1967-05-17 1970-06-02 Toa Electric Co Ltd Detecting and counting apparatus for particles suspended in a liquid

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2122369A (en) * 1982-04-29 1984-01-11 Int Remote Imaging Systems Inc A method of separating particles in a moving fluid sample
GB2172713A (en) * 1985-03-22 1986-09-24 Philips Nv Spectrometer having variable flow sample feed

Also Published As

Publication number Publication date
DE2142237A1 (en) 1972-03-02
FR2106060A5 (en) 1972-04-28
DE2142237C3 (en) 1974-08-15
DE2142237B2 (en) 1974-01-10
CH552807A (en) 1974-08-15
NL7111164A (en) 1972-03-01
AU3143671A (en) 1973-01-25
BE770541A (en) 1972-01-27
US3661460A (en) 1972-05-09
AU445066B2 (en) 1974-02-14
CA936017A (en) 1973-10-30

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees