GB1319785A - Hexahydroazepines - Google Patents
HexahydroazepinesInfo
- Publication number
- GB1319785A GB1319785A GB580470A GB1319785DA GB1319785A GB 1319785 A GB1319785 A GB 1319785A GB 580470 A GB580470 A GB 580470A GB 1319785D A GB1319785D A GB 1319785DA GB 1319785 A GB1319785 A GB 1319785A
- Authority
- GB
- United Kingdom
- Prior art keywords
- hexahydro
- lower alkyl
- azepines
- formylation
- acylation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- ZSIQJIWKELUFRJ-UHFFFAOYSA-N azepane Chemical class C1CCCNCC1 ZSIQJIWKELUFRJ-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 230000010933 acylation Effects 0.000 abstract 2
- 238000005917 acylation reaction Methods 0.000 abstract 2
- 230000029936 alkylation Effects 0.000 abstract 2
- 238000005804 alkylation reaction Methods 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 230000022244 formylation Effects 0.000 abstract 2
- 238000006170 formylation reaction Methods 0.000 abstract 2
- 239000007788 liquid Substances 0.000 abstract 2
- 230000003287 optical effect Effects 0.000 abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 2
- 238000002360 preparation method Methods 0.000 abstract 2
- 230000009467 reduction Effects 0.000 abstract 2
- 238000006722 reduction reaction Methods 0.000 abstract 2
- 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 abstract 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 1
- 229920002472 Starch Polymers 0.000 abstract 1
- XAKBSHICSHRJCL-UHFFFAOYSA-N [CH2]C(=O)C1=CC=CC=C1 Chemical group [CH2]C(=O)C1=CC=CC=C1 XAKBSHICSHRJCL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000304 alkynyl group Chemical group 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 abstract 1
- 239000002775 capsule Substances 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- JIKRTGVYDXLDFO-UHFFFAOYSA-N cyclopropyl-[3-ethyl-3-(3-hydroxyphenyl)azepan-1-yl]methanone Chemical compound C1(CC1)C(=O)N1CC(CCCC1)(C1=CC(=CC=C1)O)CC JIKRTGVYDXLDFO-UHFFFAOYSA-N 0.000 abstract 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 239000008103 glucose Substances 0.000 abstract 1
- 238000007327 hydrogenolysis reaction Methods 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 235000013336 milk Nutrition 0.000 abstract 1
- 239000008267 milk Substances 0.000 abstract 1
- 210000004080 milk Anatomy 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000002243 precursor Substances 0.000 abstract 1
- 150000003254 radicals Chemical class 0.000 abstract 1
- 150000003839 salts Chemical group 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000007787 solid Substances 0.000 abstract 1
- 238000010561 standard procedure Methods 0.000 abstract 1
- 235000019698 starch Nutrition 0.000 abstract 1
- 239000008107 starch Substances 0.000 abstract 1
- 235000000346 sugar Nutrition 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/04—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with only hydrogen atoms, halogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB580470 | 1970-02-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1319785A true GB1319785A (en) | 1973-06-06 |
Family
ID=9802925
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB580470A Expired GB1319785A (en) | 1970-02-06 | 1970-02-06 | Hexahydroazepines |
Country Status (9)
| Country | Link |
|---|---|
| BE (1) | BE762440R (enrdf_load_stackoverflow) |
| CH (1) | CH567481A5 (enrdf_load_stackoverflow) |
| DE (1) | DE2105463A1 (enrdf_load_stackoverflow) |
| FI (1) | FI52572C (enrdf_load_stackoverflow) |
| FR (1) | FR2081492B2 (enrdf_load_stackoverflow) |
| GB (1) | GB1319785A (enrdf_load_stackoverflow) |
| IE (1) | IE34900B1 (enrdf_load_stackoverflow) |
| NL (1) | NL7101378A (enrdf_load_stackoverflow) |
| ZA (1) | ZA71372B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0062019A1 (en) * | 1981-04-01 | 1982-10-06 | Aktiebolaget Hässle | New phenyl-perhydroazepines |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2666050A (en) * | 1954-01-12 | Process of producing them | ||
| US2740778A (en) * | 1956-04-03 | Hetjerqcycuc compounds and process | ||
| IE33382B1 (en) * | 1968-08-16 | 1974-06-12 | Wyeth John & Brother Ltd | Hexahydroazepines |
-
1970
- 1970-02-06 GB GB580470A patent/GB1319785A/en not_active Expired
-
1971
- 1971-01-20 IE IE69/71A patent/IE34900B1/xx unknown
- 1971-01-20 ZA ZA710372A patent/ZA71372B/xx unknown
- 1971-02-02 BE BE762440A patent/BE762440R/xx active
- 1971-02-02 NL NL7101378A patent/NL7101378A/xx not_active Application Discontinuation
- 1971-02-04 FI FI710302A patent/FI52572C/fi active
- 1971-02-05 FR FR7103913A patent/FR2081492B2/fr not_active Expired
- 1971-02-05 CH CH178571A patent/CH567481A5/xx not_active IP Right Cessation
- 1971-02-05 DE DE19712105463 patent/DE2105463A1/de not_active Ceased
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0062019A1 (en) * | 1981-04-01 | 1982-10-06 | Aktiebolaget Hässle | New phenyl-perhydroazepines |
Also Published As
| Publication number | Publication date |
|---|---|
| FI52572B (enrdf_load_stackoverflow) | 1977-06-30 |
| FR2081492B2 (enrdf_load_stackoverflow) | 1974-08-30 |
| FR2081492A2 (enrdf_load_stackoverflow) | 1971-12-03 |
| CH567481A5 (enrdf_load_stackoverflow) | 1975-10-15 |
| IE34900B1 (en) | 1975-09-17 |
| ZA71372B (en) | 1971-10-27 |
| FI52572C (fi) | 1977-10-10 |
| NL7101378A (enrdf_load_stackoverflow) | 1971-08-10 |
| BE762440R (enrdf_load_stackoverflow) | 1971-07-16 |
| IE34900L (en) | 1971-08-06 |
| DE2105463A1 (de) | 1971-08-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |