GB1311260A - Process for producing imidazo 2,1-a isoindoles - Google Patents

Process for producing imidazo 2,1-a isoindoles

Info

Publication number
GB1311260A
GB1311260A GB3670272A GB3670272A GB1311260A GB 1311260 A GB1311260 A GB 1311260A GB 3670272 A GB3670272 A GB 3670272A GB 3670272 A GB3670272 A GB 3670272A GB 1311260 A GB1311260 A GB 1311260A
Authority
GB
United Kingdom
Prior art keywords
free base
resulting
general formula
isoindoles
salification
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB3670272A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of GB1311260A publication Critical patent/GB1311260A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/20—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D233/22—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1311260 Imidazoline derivatives SANDOZ Ltd 23 Feb 1970 [19 May 1969] 36702/72 Divided out of 1306511 Heading C2C Novel imidazoline derivatives of the general formula wherein each of R and R 1 is a hydrogen, fluorine or chlorine atom, and acid addition salts thereof are prepared by reaction of the N 1 o-dilithium derivative of 2-phenyl-2-imidazoline with a benzonitrile of the general formula under an inert atmosphere and in an organic solvent which is inert under the reaction conditions, and hydrolysis of the resulting adduct, followed optionally by salification of a resulting free base or conversion of a resulting salt into the corresponding free base. They may be converted to 5-phenyl-5-hydroxy-2,3-dihydro- 5H-imidazo[2,1-a]-isoindoles of the general formula and acid addition salts thereof by treatment with water in the presence of an acid at pH 1-4, followed optionally by salification of a resulting free base or conversion of a resulting salt into the corresponding free base.
GB3670272A 1969-05-19 1970-02-23 Process for producing imidazo 2,1-a isoindoles Expired GB1311260A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82595469A 1969-05-19 1969-05-19
US86517969A 1969-10-09 1969-10-09

Publications (1)

Publication Number Publication Date
GB1311260A true GB1311260A (en) 1973-03-28

Family

ID=27124962

Family Applications (1)

Application Number Title Priority Date Filing Date
GB3670272A Expired GB1311260A (en) 1969-05-19 1970-02-23 Process for producing imidazo 2,1-a isoindoles

Country Status (2)

Country Link
CH (1) CH531510A (en)
GB (1) GB1311260A (en)

Also Published As

Publication number Publication date
CH531510A (en) 1972-12-15

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