GB1307645A - Benzopyran-5-ols and coumarin intermediates therefor - Google Patents

Benzopyran-5-ols and coumarin intermediates therefor

Info

Publication number
GB1307645A
GB1307645A GB4668270A GB4668270A GB1307645A GB 1307645 A GB1307645 A GB 1307645A GB 4668270 A GB4668270 A GB 4668270A GB 4668270 A GB4668270 A GB 4668270A GB 1307645 A GB1307645 A GB 1307645A
Authority
GB
United Kingdom
Prior art keywords
formula
group
piperidinyl
oct
pharmaceutically acceptable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4668270A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of GB1307645A publication Critical patent/GB1307645A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1307645 Piperidinyl-benzopyran derivatives BEECHAM GROUP Ltd 1 Oct 1970 [31 Oct 1969] 46682/70 Heading C2C Novel compounds of Formula (I): wherein R 1 is a C 1-6 alkyl group, R 2 is a C 1-20 aliphatic hydrocarbon group, R 3 is H, a C 1-12 hydrocarbon or an acyl-group COR 4 , where R 4 is a C 1-12 hydrocarbon group, and pharmaceutically acceptable salts, N-oxides, esters and ethers, may be obtained by reacting a chromanone (II): with a Grignard reagent R 1 MgY, where Y is Br, Cl, or I, to yield a compound (Ia), and optionally converting to other products of Formula (I) by acylation or hydrocarbonylation, or forming an N-oxide, ester, ether or salt. An intermediate, 4-(1-benzoyl-4-piperidinyl) - 5 - hydroxy - 7 - pentyl coumarin is obtained by reaction of ethyl #-oxo-4-piperidine-N- benzoyl propionate and olivetol with cone sulphuric acid and phosphorus oxychloride. Pharmaceutical compositions, useful as antidepressants, anti-anxiety agents, hypotensives and analgesics, comprise compounds of Formula (I) together with a pharmaceutically acceptable carrier in forms suitable for. oral or parenteral administration.
GB4668270A 1969-10-31 1970-10-01 Benzopyran-5-ols and coumarin intermediates therefor Expired GB1307645A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US87307969A 1969-10-31 1969-10-31

Publications (1)

Publication Number Publication Date
GB1307645A true GB1307645A (en) 1973-02-21

Family

ID=25360940

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4668270A Expired GB1307645A (en) 1969-10-31 1970-10-01 Benzopyran-5-ols and coumarin intermediates therefor

Country Status (5)

Country Link
BE (1) BE758328A (en)
DE (1) DE2053405A1 (en)
FR (1) FR2070183B1 (en)
GB (1) GB1307645A (en)
ZA (1) ZA706818B (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE794630A (en) * 1972-01-26 1973-07-26 Beecham Group Ltd ANTI-HYPERTENSIVE POLYCYCLIC COMPOUNDS
FR2189027B1 (en) * 1972-06-21 1976-03-05 Leurquin Laboratoires Fr

Also Published As

Publication number Publication date
ZA706818B (en) 1971-07-28
DE2053405A1 (en) 1971-05-06
FR2070183A1 (en) 1971-09-10
FR2070183B1 (en) 1974-10-11
BE758328A (en) 1971-04-30

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees