GB1301319A - - Google Patents
Info
- Publication number
- GB1301319A GB1301319A GB1301319DA GB1301319A GB 1301319 A GB1301319 A GB 1301319A GB 1301319D A GB1301319D A GB 1301319DA GB 1301319 A GB1301319 A GB 1301319A
- Authority
- GB
- United Kingdom
- Prior art keywords
- acylation
- sulphur
- followed
- oxygen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 3
- 239000005864 Sulphur Chemical group 0.000 abstract 3
- 230000010933 acylation Effects 0.000 abstract 3
- 238000005917 acylation reaction Methods 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 3
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- PXBFMLJZNCDSMP-UHFFFAOYSA-N 2-Aminobenzamide Chemical compound NC(=O)C1=CC=CC=C1N PXBFMLJZNCDSMP-UHFFFAOYSA-N 0.000 abstract 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 abstract 2
- 150000001408 amides Chemical class 0.000 abstract 2
- RWZYAGGXGHYGMB-UHFFFAOYSA-N anthranilic acid Chemical compound NC1=CC=CC=C1C(O)=O RWZYAGGXGHYGMB-UHFFFAOYSA-N 0.000 abstract 2
- 238000006243 chemical reaction Methods 0.000 abstract 2
- 238000007363 ring formation reaction Methods 0.000 abstract 2
- 101100294115 Caenorhabditis elegans nhr-4 gene Proteins 0.000 abstract 1
- 241001061127 Thione Species 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical group 0.000 abstract 1
- 150000001351 alkyl iodides Chemical class 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 229910021529 ammonia Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- YWEUIGNSBFLMFL-UHFFFAOYSA-N diphosphonate Chemical compound O=P(=O)OP(=O)=O YWEUIGNSBFLMFL-UHFFFAOYSA-N 0.000 abstract 1
- 238000010438 heat treatment Methods 0.000 abstract 1
- 239000004009 herbicide Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- -1 organic base salts Chemical class 0.000 abstract 1
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical group [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- DLYUQMMRRRQYAE-UHFFFAOYSA-N phosphorus pentoxide Inorganic materials O1P(O2)(=O)OP3(=O)OP1(=O)OP2(=O)O3 DLYUQMMRRRQYAE-UHFFFAOYSA-N 0.000 abstract 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 1
- 150000003568 thioethers Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/88—Oxygen atoms
- C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5461870A | 1970-07-13 | 1970-07-13 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1301319A true GB1301319A (enrdf_load_stackoverflow) | 1972-12-29 |
Family
ID=21992345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1301319D Expired GB1301319A (enrdf_load_stackoverflow) | 1970-07-13 | 1970-11-13 |
Country Status (4)
| Country | Link |
|---|---|
| JP (2) | JPS555507B1 (enrdf_load_stackoverflow) |
| DE (1) | DE2134263A1 (enrdf_load_stackoverflow) |
| FR (1) | FR2098361B1 (enrdf_load_stackoverflow) |
| GB (1) | GB1301319A (enrdf_load_stackoverflow) |
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251531A (en) | 1975-12-05 | 1981-02-17 | Farmitalia Carlo Erba S.P.A. | 3,4-Dihydro-quinazoline derivatives |
| WO2008009077A3 (en) * | 2006-07-20 | 2008-12-24 | Gilead Sciences Inc | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
| US9259426B2 (en) | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US10285990B2 (en) | 2015-03-04 | 2019-05-14 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US10370342B2 (en) | 2016-09-02 | 2019-08-06 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US11286257B2 (en) | 2019-06-28 | 2022-03-29 | Gilead Sciences, Inc. | Processes for preparing toll-like receptor modulator compounds |
| US11396509B2 (en) | 2019-04-17 | 2022-07-26 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
| US11583531B2 (en) | 2019-04-17 | 2023-02-21 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19530451A1 (de) * | 1995-08-18 | 1997-02-20 | Bayer Ag | Substituierte Chinazolin(thi)one |
-
1970
- 1970-11-13 GB GB1301319D patent/GB1301319A/en not_active Expired
-
1971
- 1971-07-09 JP JP5040271A patent/JPS555507B1/ja active Pending
- 1971-07-09 DE DE19712134263 patent/DE2134263A1/de active Pending
- 1971-07-09 FR FR7125300A patent/FR2098361B1/fr not_active Expired
-
1978
- 1978-12-08 JP JP15186078A patent/JPS5598103A/ja active Pending
Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4251531A (en) | 1975-12-05 | 1981-02-17 | Farmitalia Carlo Erba S.P.A. | 3,4-Dihydro-quinazoline derivatives |
| US12049461B2 (en) | 2006-07-20 | 2024-07-30 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| WO2008009077A3 (en) * | 2006-07-20 | 2008-12-24 | Gilead Sciences Inc | 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
| US8673929B2 (en) | 2006-07-20 | 2014-03-18 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections |
| US9259426B2 (en) | 2006-07-20 | 2016-02-16 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US10882851B2 (en) | 2006-07-20 | 2021-01-05 | Gilead Sciences, Inc. | 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections |
| US10285990B2 (en) | 2015-03-04 | 2019-05-14 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US12377100B2 (en) | 2015-03-04 | 2025-08-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US10640499B2 (en) | 2016-09-02 | 2020-05-05 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US11827609B2 (en) | 2016-09-02 | 2023-11-28 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US11124487B2 (en) | 2016-09-02 | 2021-09-21 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US10370342B2 (en) | 2016-09-02 | 2019-08-06 | Gilead Sciences, Inc. | Toll like receptor modulator compounds |
| US11396509B2 (en) | 2019-04-17 | 2022-07-26 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
| US11583531B2 (en) | 2019-04-17 | 2023-02-21 | Gilead Sciences, Inc. | Solid forms of a toll-like receptor modulator |
| US11286257B2 (en) | 2019-06-28 | 2022-03-29 | Gilead Sciences, Inc. | Processes for preparing toll-like receptor modulator compounds |
Also Published As
| Publication number | Publication date |
|---|---|
| JPS555507B1 (enrdf_load_stackoverflow) | 1980-02-07 |
| FR2098361A1 (enrdf_load_stackoverflow) | 1972-03-10 |
| DE2134263A1 (de) | 1972-02-03 |
| FR2098361B1 (enrdf_load_stackoverflow) | 1974-11-08 |
| JPS5598103A (en) | 1980-07-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |