GB1301319A - - Google Patents

Info

Publication number
GB1301319A
GB1301319A GB1301319DA GB1301319A GB 1301319 A GB1301319 A GB 1301319A GB 1301319D A GB1301319D A GB 1301319DA GB 1301319 A GB1301319 A GB 1301319A
Authority
GB
United Kingdom
Prior art keywords
acylation
sulphur
followed
oxygen
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed filed Critical
Publication of GB1301319A publication Critical patent/GB1301319A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/90—Oxygen atoms with acyclic radicals attached in position 2 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

1301319 Quinazolines PFIZER Inc 13 Nov 1970 [13 July 1970] 54241/70 Heading C2C Compounds of formula wherein R 1 is F, Cl or C 1-4 -perfluoroalkyl, R 2 and R 3 are each H, Cl, Br, I, -CN, -NO 2 , phenyl, -OH, -NH 2 , -CONH 2 , -SO 2 NH 2 , C 1-2 - perfluoroalkyl, -SOR 4 , -SO 2 R 4 , -OCOR 4 , -NHCOR 4 , -CONHR 4 , -SO 2 NHR 4 , -CONHR 4 R 5 or -SO 2 NR 4 R 5 , in which each of R 4 and R 5 is C 1-4 -alkyl, or -NR 4 R 5 forms a C 4-8 -heterocycle, X is oxygen or sulphur, and R 6 is C 1-5 -alkyl and, when X is oxygen or sulphur, alkali metal or strong organic base salts thereof, are prepared by (a) acylation of an anthranilic acid, followed by cyclization of the amide with ammonia, (b) acylation of an anthranilamide, followed by cyclization of the amide by heating, (c) conversion of X from oxygen to sulphur by phosphorus pentoxide, (d) conversion of a thione to a thioether by an alkyl iodide, or (e) reduction of a nitro group R 2 or R 3 to an amino group, followed by acylation. The products are herbicides.
GB1301319D 1970-07-13 1970-11-13 Expired GB1301319A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5461870A 1970-07-13 1970-07-13

Publications (1)

Publication Number Publication Date
GB1301319A true GB1301319A (en) 1972-12-29

Family

ID=21992345

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1301319D Expired GB1301319A (en) 1970-07-13 1970-11-13

Country Status (4)

Country Link
JP (2) JPS555507B1 (en)
DE (1) DE2134263A1 (en)
FR (1) FR2098361B1 (en)
GB (1) GB1301319A (en)

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008009077A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
US9259426B2 (en) 2006-07-20 2016-02-16 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US10285990B2 (en) 2015-03-04 2019-05-14 Gilead Sciences, Inc. Toll like receptor modulator compounds
US10370342B2 (en) 2016-09-02 2019-08-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
US11286257B2 (en) 2019-06-28 2022-03-29 Gilead Sciences, Inc. Processes for preparing toll-like receptor modulator compounds
US11396509B2 (en) 2019-04-17 2022-07-26 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US11583531B2 (en) 2019-04-17 2023-02-21 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19530451A1 (en) * 1995-08-18 1997-02-20 Bayer Ag Substituted quinazoline (thi) one

Cited By (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008009077A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
WO2008009077A3 (en) * 2006-07-20 2008-12-24 Gilead Sciences Inc 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
US8673929B2 (en) 2006-07-20 2014-03-18 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
US9259426B2 (en) 2006-07-20 2016-02-16 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US10882851B2 (en) 2006-07-20 2021-01-05 Gilead Sciences, Inc. 4,6-di- and 2,4,6-trisubstituted quinazoline derivatives useful for treating viral infections
US10285990B2 (en) 2015-03-04 2019-05-14 Gilead Sciences, Inc. Toll like receptor modulator compounds
US10640499B2 (en) 2016-09-02 2020-05-05 Gilead Sciences, Inc. Toll like receptor modulator compounds
US10370342B2 (en) 2016-09-02 2019-08-06 Gilead Sciences, Inc. Toll like receptor modulator compounds
US11124487B2 (en) 2016-09-02 2021-09-21 Gilead Sciences, Inc. Toll like receptor modulator compounds
US11827609B2 (en) 2016-09-02 2023-11-28 Gilead Sciences, Inc. Toll like receptor modulator compounds
US11396509B2 (en) 2019-04-17 2022-07-26 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US11583531B2 (en) 2019-04-17 2023-02-21 Gilead Sciences, Inc. Solid forms of a toll-like receptor modulator
US11286257B2 (en) 2019-06-28 2022-03-29 Gilead Sciences, Inc. Processes for preparing toll-like receptor modulator compounds

Also Published As

Publication number Publication date
DE2134263A1 (en) 1972-02-03
FR2098361B1 (en) 1974-11-08
JPS5598103A (en) 1980-07-25
FR2098361A1 (en) 1972-03-10
JPS555507B1 (en) 1980-02-07

Similar Documents

Publication Publication Date Title
GB1353179A (en) Hydantoin derivatives processes for producing them and compositions containing them
GB1313789A (en) Quinazoline derivatives and processes for producing them
ES356462A1 (en) Isothiocyanobenzazoles and use thereof as anthelmintics
GB1301319A (en)
GB1340596A (en) Tetrahydrobenzothiazolyl derivatives and their use as herbicides
ES430119A1 (en) 2-(Phenyl-amino-2-imidazolines and salts thereof
GB1312391A (en) Basically substituted 4 3h- quinazolinone derivatives and process for their manufacture
GB1337737A (en) Benzodiazepine derivatives
GB1096006A (en) Substituted biurets
GB1341884A (en) Herbicidal 1,2,4-thiadiazolyl derivatives
GB1225714A (en)
ATE24728T1 (en) 3-AMINO-6-ARYL-1,2,4-TRIAZOLO(4,3-B)-PYRIDAZINE THEIR PRODUCTION AND USE.
GB1410178A (en) Substituted quinazolinones as herbicides
GB1185039A (en) Pyrimidine Derivatives and Compositions containing them
GB1363415A (en) Bis-pyridyl amine compounds
GB1367305A (en) Benzodiazocine derivatives
GB1359224A (en) Triazolobenzodiazepine derivatives
GB1504707A (en) 1-aryl-2-oxo-2,4,5,6,7,7a-hexahydroindoles
GB1492006A (en) Process for the production of maddrell's salt
GB1199857A (en) o-Substituted 2-Phenylimino-1-Azacycloheptanes and their production
GB1247463A (en) 0,3,4-thiadiazoline-5-(thi)onyl-(thio)-ureas
GB1514907A (en) Process for the preparation of substituted phenylguanidines and substituted phenylguanidines when thus prepared
GB904895A (en) Amidinobenzene sulphonamides
GB1528462A (en) Preparation of 2-equivalent colour couplers for yellow
GB1011288A (en) Benzoxazine-2:4-dione derivatives and a process of making same

Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee