GB1292269A - Pregnane derivatives and process for preparation thereof - Google Patents
Pregnane derivatives and process for preparation thereofInfo
- Publication number
- GB1292269A GB1292269A GB986870A GB986870A GB1292269A GB 1292269 A GB1292269 A GB 1292269A GB 986870 A GB986870 A GB 986870A GB 986870 A GB986870 A GB 986870A GB 1292269 A GB1292269 A GB 1292269A
- Authority
- GB
- United Kingdom
- Prior art keywords
- group
- triamcinolone
- alkanoyl radical
- preparation
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003126 pregnane derivatives Chemical class 0.000 title 1
- HGINCPLSRVDWNT-UHFFFAOYSA-N Acrolein Chemical compound C=CC=O HGINCPLSRVDWNT-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- GFNANZIMVAIWHM-OBYCQNJPSA-N triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 abstract 2
- 229960005294 triamcinolone Drugs 0.000 abstract 2
- 239000003377 acid catalyst Substances 0.000 abstract 1
- 230000010933 acylation Effects 0.000 abstract 1
- 238000005917 acylation reaction Methods 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- 150000001340 alkali metals Chemical class 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 230000002394 glycogenic effect Effects 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000003096 thymolvtic effect Effects 0.000 abstract 1
- 238000011200 topical administration Methods 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR6906348A FR2035766A1 (en) | 1969-03-07 | 1969-03-07 | Preparation of prenane derivs |
| FR6938912A FR2068427A1 (en) | 1969-11-13 | 1969-11-13 | Preparation of prenane derivs |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1292269A true GB1292269A (en) | 1972-10-11 |
Family
ID=26214890
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB986870A Expired GB1292269A (en) | 1969-03-07 | 1970-03-02 | Pregnane derivatives and process for preparation thereof |
Country Status (9)
| Country | Link |
|---|---|
| JP (1) | JPS4843910B1 (https=) |
| BE (1) | BE746965A (https=) |
| DK (1) | DK122812B (https=) |
| ES (1) | ES376421A1 (https=) |
| FI (1) | FI47573C (https=) |
| GB (1) | GB1292269A (https=) |
| NL (1) | NL7001308A (https=) |
| NO (1) | NO134746C (https=) |
| SE (1) | SE360652B (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019136487A3 (en) * | 2018-01-08 | 2019-09-12 | Regeneron Pharmaceuticals, Inc. | Steroids and antibody-conjugates thereof |
-
1970
- 1970-01-29 NL NL7001308A patent/NL7001308A/xx unknown
- 1970-02-10 ES ES376421A patent/ES376421A1/es not_active Expired
- 1970-03-02 GB GB986870A patent/GB1292269A/en not_active Expired
- 1970-03-04 FI FI58970A patent/FI47573C/fi active
- 1970-03-05 SE SE293170A patent/SE360652B/xx unknown
- 1970-03-06 BE BE746965D patent/BE746965A/xx not_active IP Right Cessation
- 1970-03-06 NO NO80170A patent/NO134746C/no unknown
- 1970-03-07 JP JP1967870A patent/JPS4843910B1/ja active Pending
- 1970-03-09 DK DK114170A patent/DK122812B/da not_active IP Right Cessation
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019136487A3 (en) * | 2018-01-08 | 2019-09-12 | Regeneron Pharmaceuticals, Inc. | Steroids and antibody-conjugates thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| NO134746B (https=) | 1976-08-30 |
| DK122812B (da) | 1972-04-17 |
| DE2006635A1 (de) | 1970-09-24 |
| BE746965A (fr) | 1970-09-07 |
| NL7001308A (https=) | 1970-09-09 |
| SE360652B (https=) | 1973-10-01 |
| FI47573C (fi) | 1974-01-10 |
| ES376421A1 (es) | 1972-04-16 |
| NO134746C (https=) | 1976-12-08 |
| FI47573B (https=) | 1973-10-01 |
| JPS4843910B1 (https=) | 1973-12-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |