GB1277227A - Aryl esters - Google Patents
Aryl estersInfo
- Publication number
- GB1277227A GB1277227A GB48814/69A GB4881469A GB1277227A GB 1277227 A GB1277227 A GB 1277227A GB 48814/69 A GB48814/69 A GB 48814/69A GB 4881469 A GB4881469 A GB 4881469A GB 1277227 A GB1277227 A GB 1277227A
- Authority
- GB
- United Kingdom
- Prior art keywords
- trans
- phenyl
- aryl
- group
- carboxylate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000007860 aryl ester derivatives Chemical class 0.000 title abstract 2
- 125000003118 aryl group Chemical group 0.000 abstract 7
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 7
- -1 4 - aminomethyl - phenyl group Chemical group 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 125000006239 protecting group Chemical group 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 229910052736 halogen Inorganic materials 0.000 abstract 3
- 150000002367 halogens Chemical class 0.000 abstract 3
- 125000003277 amino group Chemical group 0.000 abstract 2
- 125000004181 carboxyalkyl group Chemical group 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 229910000033 sodium borohydride Inorganic materials 0.000 abstract 2
- 239000012279 sodium borohydride Substances 0.000 abstract 2
- STPXIOFWKOIYHX-UHFFFAOYSA-N 1-methylcyclohexane-1-carbonyl chloride Chemical compound ClC(=O)C1(C)CCCCC1 STPXIOFWKOIYHX-UHFFFAOYSA-N 0.000 abstract 1
- 101710081722 Antitrypsin Proteins 0.000 abstract 1
- 101100188552 Arabidopsis thaliana OCT3 gene Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000003342 alkenyl group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000004453 alkoxycarbonyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- 230000000288 anti-kallikrein effect Effects 0.000 abstract 1
- 230000001475 anti-trypsic effect Effects 0.000 abstract 1
- HSDAJNMJOMSNEV-UHFFFAOYSA-N benzyl chloroformate Chemical compound ClC(=O)OCC1=CC=CC=C1 HSDAJNMJOMSNEV-UHFFFAOYSA-N 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000005019 carboxyalkenyl group Chemical group 0.000 abstract 1
- 125000005111 carboxyalkoxy group Chemical group 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 125000002485 formyl group Chemical group [H]C(*)=O 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002768 hydroxyalkyl group Chemical group 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 238000010647 peptide synthesis reaction Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 150000002989 phenols Chemical class 0.000 abstract 1
- ZATKCOLXKXVOPB-UHFFFAOYSA-N phenylmethoxycarbonylaminomethyl benzoate Chemical class C(C1=CC=CC=C1)OC(=O)NCOC(C1=CC=CC=C1)=O ZATKCOLXKXVOPB-UHFFFAOYSA-N 0.000 abstract 1
- 229940012957 plasmin Drugs 0.000 abstract 1
- 125000004076 pyridyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000002753 trypsin inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/38—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino groups bound to acyclic carbon atoms and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/89—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members with hetero atoms directly attached to the ring nitrogen atom
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP7422068 | 1968-10-14 | ||
| JP9056468 | 1968-12-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1277227A true GB1277227A (en) | 1972-06-07 |
Family
ID=26415343
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB48814/69A Expired GB1277227A (en) | 1968-10-14 | 1969-10-03 | Aryl esters |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US3699149A (en:Method) |
| AT (1) | AT291976B (en:Method) |
| BE (1) | BE740202A (en:Method) |
| CA (1) | CA929942A (en:Method) |
| CH (1) | CH523222A (en:Method) |
| DE (1) | DE1951061A1 (en:Method) |
| DK (1) | DK122954B (en:Method) |
| ES (1) | ES372360A1 (en:Method) |
| FI (1) | FI52076C (en:Method) |
| FR (1) | FR2020646B1 (en:Method) |
| GB (1) | GB1277227A (en:Method) |
| IE (1) | IE33596B1 (en:Method) |
| IL (1) | IL33104A (en:Method) |
| NL (1) | NL146790B (en:Method) |
| NO (1) | NO130583C (en:Method) |
| PH (1) | PH9762A (en:Method) |
| PL (1) | PL80293B1 (en:Method) |
| RO (1) | RO57232A (en:Method) |
| SE (1) | SE365506B (en:Method) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005058798A3 (en) * | 2003-12-17 | 2006-02-16 | Allergan Inc | Compounds having selective cytochrome p450rai-1 or selective cytochrome p450rai-2 inhibitory activity and methods of obtaining the same |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4069240A (en) * | 1975-09-04 | 1978-01-17 | Uniroyal, Inc. | Nuclear hydrogenation of n-aryl carbamates |
| US4147876A (en) * | 1978-05-01 | 1979-04-03 | Daiichi Seiyaku Co., Ltd. | Easily hydrolyzable esters of 4-(2-carboxyethyl)phenyl trans-4-aminomethylcyclohexanecarboxylate and process of use |
| DE2819462A1 (de) * | 1978-05-03 | 1979-11-08 | Daiichi Seiyaku Co | Verfahren zur herstellung von 4'-(2-carboxyaethyl)phenyl-trans-4-aminomethylcyclohexan-carboxylat oder seiner saeureadditionssalze und neue zwischenprodukte zur herstellung dieser verbindung |
| FR2424902A1 (fr) * | 1978-05-03 | 1979-11-30 | Daiichi Seiyaku Co | Procede pour la preparation de trans-4-aminomethylcyclohexanecarboxylate de 4'-(2-carboxyethyl)phenyle ou de ses sels d'addition d'acides et intermediaires utiles dans cette preparation |
| US4313435A (en) | 1980-04-18 | 1982-02-02 | Gulf & Western Corporation | Apparatus and method of producing a succession of die cut tobacco blanks |
| US4465851A (en) * | 1981-01-22 | 1984-08-14 | Nippon Chemiphar Co., Ltd. | Guanidinocyclohexanecarboxylic acid derivatives |
| DE3262698D1 (en) * | 1981-11-17 | 1985-04-25 | Kabivitrum Ab | Antifibrinolytically active compounds |
| WO1999055661A1 (en) * | 1998-04-24 | 1999-11-04 | Proteus Molecular Design Limited | Aminomethyl-benzoic ester derivatives as tryptase inhibitors |
| EP1898922A4 (en) * | 2005-07-04 | 2012-03-14 | Ramu Krishnan | MEDICINE OR IMPROVED PHARMACEUTICAL COMPOUNDS AND PREPARATION THEREOF |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DD48209A (en:Method) * |
-
1969
- 1969-09-30 US US862512A patent/US3699149A/en not_active Expired - Lifetime
- 1969-09-30 CA CA063735A patent/CA929942A/en not_active Expired
- 1969-10-01 IL IL33104A patent/IL33104A/en unknown
- 1969-10-03 GB GB48814/69A patent/GB1277227A/en not_active Expired
- 1969-10-08 IE IE1393/69A patent/IE33596B1/xx unknown
- 1969-10-08 SE SE13844/69A patent/SE365506B/xx unknown
- 1969-10-09 ES ES372360A patent/ES372360A1/es not_active Expired
- 1969-10-10 CH CH1525769A patent/CH523222A/de not_active IP Right Cessation
- 1969-10-10 PH PH10787A patent/PH9762A/en unknown
- 1969-10-10 PL PL1969136290A patent/PL80293B1/pl unknown
- 1969-10-10 DE DE19691951061 patent/DE1951061A1/de active Granted
- 1969-10-13 DK DK542769AA patent/DK122954B/da not_active IP Right Cessation
- 1969-10-13 BE BE740202D patent/BE740202A/xx not_active IP Right Cessation
- 1969-10-13 FR FR6935019A patent/FR2020646B1/fr not_active Expired
- 1969-10-14 RO RO61267A patent/RO57232A/ro unknown
- 1969-10-14 NL NL696915495A patent/NL146790B/xx not_active IP Right Cessation
- 1969-10-14 AT AT09657/69A patent/AT291976B/de active
- 1969-10-14 NO NO4087/69A patent/NO130583C/no unknown
- 1969-10-14 FI FI692959A patent/FI52076C/fi active
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005058798A3 (en) * | 2003-12-17 | 2006-02-16 | Allergan Inc | Compounds having selective cytochrome p450rai-1 or selective cytochrome p450rai-2 inhibitory activity and methods of obtaining the same |
| US7226951B2 (en) | 2003-12-17 | 2007-06-05 | Allergan, Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
| US7638648B2 (en) | 2003-12-17 | 2009-12-29 | Allergan Inc. | Compounds having selective cytochrome P450RAI-1 or selective cytochrome P450RAI-2 inhibitory activity and methods of obtaining the same |
Also Published As
| Publication number | Publication date |
|---|---|
| NO130583B (en:Method) | 1974-09-30 |
| ES372360A1 (es) | 1972-03-16 |
| NO130583C (en:Method) | 1975-01-15 |
| RO57232A (en:Method) | 1975-01-15 |
| IL33104A (en) | 1973-01-30 |
| FR2020646A1 (en:Method) | 1970-07-17 |
| SE365506B (en:Method) | 1974-03-25 |
| CH523222A (de) | 1972-05-31 |
| AT291976B (de) | 1971-07-15 |
| DK122954B (da) | 1972-05-01 |
| PH9762A (en) | 1976-03-12 |
| FR2020646B1 (en:Method) | 1974-05-24 |
| IE33596L (en) | 1970-04-14 |
| FI52076C (fi) | 1977-06-10 |
| DE1951061A1 (de) | 1970-06-25 |
| BE740202A (en:Method) | 1970-04-13 |
| IE33596B1 (en) | 1974-08-21 |
| CA929942A (en) | 1973-07-10 |
| US3699149A (en) | 1972-10-17 |
| NL146790B (nl) | 1975-08-15 |
| FI52076B (en:Method) | 1977-02-28 |
| PL80293B1 (en) | 1975-08-30 |
| IL33104A0 (en) | 1969-12-31 |
| NL6915495A (en:Method) | 1970-04-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PE20 | Patent expired after termination of 20 years |