GB1272841A - New corticoid steroid compounds of cytostatic interest - Google Patents
New corticoid steroid compounds of cytostatic interestInfo
- Publication number
- GB1272841A GB1272841A GB3952/69A GB395269A GB1272841A GB 1272841 A GB1272841 A GB 1272841A GB 3952/69 A GB3952/69 A GB 3952/69A GB 395269 A GB395269 A GB 395269A GB 1272841 A GB1272841 A GB 1272841A
- Authority
- GB
- United Kingdom
- Prior art keywords
- amino
- chloroethyl
- bis
- compounds
- reaction
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000003470 adrenal cortex hormone Substances 0.000 title 1
- -1 corticoid steroid compounds Chemical class 0.000 title 1
- 239000000824 cytostatic agent Substances 0.000 title 1
- 230000001085 cytostatic effect Effects 0.000 title 1
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 4
- FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 abstract 4
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 2
- 150000007513 acids Chemical class 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 239000011203 carbon fibre reinforced carbon Substances 0.000 abstract 2
- 239000003246 corticosteroid Substances 0.000 abstract 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 2
- PDUQYHSWRUIXCI-UHFFFAOYSA-N 2-[4-[bis(2-chloroethyl)amino]phenyl]-2-methylpropanoyl chloride Chemical compound ClCCN(CCCl)C1=CC=C(C=C1)C(C(=O)Cl)(C)C PDUQYHSWRUIXCI-UHFFFAOYSA-N 0.000 abstract 1
- JSDITRAWIKWHTB-UHFFFAOYSA-N 2-[bis(2-chloroethyl)amino]-4-methylbenzoyl chloride Chemical compound ClCCN(CCCl)C=1C=C(C=CC1C(=O)Cl)C JSDITRAWIKWHTB-UHFFFAOYSA-N 0.000 abstract 1
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 abstract 1
- FYWSBUKNPDTATO-UHFFFAOYSA-N 3-[4-[bis(2-chloroethyl)amino]phenyl]butanoyl 3-[4-[bis(2-chloroethyl)amino]phenyl]butanoate Chemical compound ClCCN(CCCl)C1=CC=C(C=C1)C(CC(=O)OC(CC(C)C1=CC=C(C=C1)N(CCCl)CCCl)=O)C FYWSBUKNPDTATO-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 239000005864 Sulphur Chemical group 0.000 abstract 1
- UVCLSTMPJQIITB-UHFFFAOYSA-N [2-[4-[bis(2-chloroethyl)amino]phenyl]sulfanylacetyl] 2-[4-[bis(2-chloroethyl)amino]phenyl]sulfanylacetate Chemical compound ClCCN(CCCl)C1=CC=C(C=C1)SCC(=O)OC(CSC1=CC=C(C=C1)N(CCCl)CCCl)=O UVCLSTMPJQIITB-UHFFFAOYSA-N 0.000 abstract 1
- IIUCZXAVDYFVJA-UHFFFAOYSA-N [2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoyl] 2-acetamido-3-[4-[bis(2-chloroethyl)amino]phenyl]propanoate Chemical compound C=1C=C(N(CCCl)CCCl)C=CC=1CC(NC(C)=O)C(=O)OC(=O)C(NC(=O)C)CC1=CC=C(N(CCCl)CCCl)C=C1 IIUCZXAVDYFVJA-UHFFFAOYSA-N 0.000 abstract 1
- 150000008065 acid anhydrides Chemical class 0.000 abstract 1
- 125000005236 alkanoylamino group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 230000000259 anti-tumor effect Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 239000000969 carrier Substances 0.000 abstract 1
- 125000001475 halogen functional group Chemical group 0.000 abstract 1
- 238000002513 implantation Methods 0.000 abstract 1
- SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Substances 0.000 abstract 1
- 239000008188 pellet Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by an uninterrupted chain of only two carbon atoms, e.g. pregnane derivatives
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Priority Applications (17)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3952/69A GB1272841A (en) | 1969-01-23 | 1969-01-23 | New corticoid steroid compounds of cytostatic interest |
| DE2001305A DE2001305C3 (de) | 1969-01-23 | 1970-01-13 | Cytostatisch wirksame Corticosteroid-21 -ester, deren Herstellung sowie diese enthaltende Arzneimittel |
| NO123/70A NO130476C (enExample) | 1969-01-23 | 1970-01-13 | |
| CH49670A CH534143A (de) | 1969-01-23 | 1970-01-14 | Verfahren zur Herstellung von Corticosteroidestern |
| US00004067A US3732260A (en) | 1969-01-23 | 1970-01-19 | Corticoid steroid compounds |
| FI700138A FI47659C (fi) | 1969-01-23 | 1970-01-19 | Analogiamenetelmä kortikosteroidien 21-estereiden tai niiden happoaddi tiosuolojen valmistamiseksi. |
| ES375613A ES375613A1 (es) | 1969-01-23 | 1970-01-19 | Metodo para preparar 21-esteres de coticosteroides. |
| SE00674/70A SE358387B (enExample) | 1969-01-23 | 1970-01-20 | |
| IE80/70A IE33953B1 (en) | 1969-01-23 | 1970-01-21 | New corticoid steroid compounds of cytostatic interest |
| FR7002113A FR2034483B1 (enExample) | 1969-01-23 | 1970-01-21 | |
| CA072847A CA935152A (en) | 1969-01-23 | 1970-01-22 | Corticoid steroid compounds |
| DK29470AA DK123713B (da) | 1969-01-23 | 1970-01-22 | Analogifremgangsmåde til fremstilling af 21-estere af corticosteroider eller syreadditionssalte deraf. |
| BE744766D BE744766A (fr) | 1969-01-23 | 1970-01-22 | 21-esters d'hormones steroides corticoides et procede pour leurpreparation |
| NL7000977.A NL160570C (nl) | 1969-01-23 | 1970-01-23 | Werkwijze voor het bereiden van geneesmiddelen met kanker remmende eigenschappen door een corticosteroide met een n-bis-(chloorethyl)-aminogroep houdende zijketen in een voor geneeskundige doeleinden geschikte toedieningsvorm te brengen, aldus verkregen gevormde geneesmiddelen, alsmede werkwijze voor het bereiden van daarvoor geschikte genees- krachtige verbindingen. |
| BR216251/70A BR7016251D0 (pt) | 1969-01-23 | 1970-01-23 | Processo para preparar 2l-esteres de um esteroide de corticoide |
| AT64870A AT300212B (de) | 1969-01-23 | 1970-01-23 | Verfahren zur Herstellung von neuen cytostatisch wirksamen Corticosteroid-21-estern |
| US05/335,761 US4029778A (en) | 1969-01-23 | 1973-03-13 | Cortical steroid nitrogen mustard compositions and treatment therewith |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB3952/69A GB1272841A (en) | 1969-01-23 | 1969-01-23 | New corticoid steroid compounds of cytostatic interest |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1272841A true GB1272841A (en) | 1972-05-03 |
Family
ID=9767981
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB3952/69A Expired GB1272841A (en) | 1969-01-23 | 1969-01-23 | New corticoid steroid compounds of cytostatic interest |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US3732260A (enExample) |
| AT (1) | AT300212B (enExample) |
| BE (1) | BE744766A (enExample) |
| BR (1) | BR7016251D0 (enExample) |
| CA (1) | CA935152A (enExample) |
| CH (1) | CH534143A (enExample) |
| DE (1) | DE2001305C3 (enExample) |
| DK (1) | DK123713B (enExample) |
| ES (1) | ES375613A1 (enExample) |
| FI (1) | FI47659C (enExample) |
| FR (1) | FR2034483B1 (enExample) |
| GB (1) | GB1272841A (enExample) |
| IE (1) | IE33953B1 (enExample) |
| NL (1) | NL160570C (enExample) |
| NO (1) | NO130476C (enExample) |
| SE (1) | SE358387B (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001219A (en) * | 1975-02-13 | 1977-01-04 | Leandro Baiocchi | Steroidal derivatives of bendazolic acid and process for the preparation of the same |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4261910A (en) * | 1978-08-14 | 1981-04-14 | Kureha Kagaku Kogyo Kabushiki Kaisha | Process for the preparation of Chlorambucil derivatives |
| CH666044A5 (de) * | 1984-07-31 | 1988-06-30 | Onkologi N Ct Ak Med V | Derivate von 11-desoxy-17 alpha-oxykortikosteron. |
| DK1407784T3 (da) * | 2001-06-25 | 2011-02-28 | Ajinomoto Kk | Antitumormidler |
| ES2694481T3 (es) * | 2008-05-23 | 2018-12-21 | The University Of British Columbia | Fármacos modificados para su uso en nanopartículas liposomales |
-
1969
- 1969-01-23 GB GB3952/69A patent/GB1272841A/en not_active Expired
-
1970
- 1970-01-13 NO NO123/70A patent/NO130476C/no unknown
- 1970-01-13 DE DE2001305A patent/DE2001305C3/de not_active Expired
- 1970-01-14 CH CH49670A patent/CH534143A/de not_active IP Right Cessation
- 1970-01-19 ES ES375613A patent/ES375613A1/es not_active Expired
- 1970-01-19 FI FI700138A patent/FI47659C/fi active
- 1970-01-19 US US00004067A patent/US3732260A/en not_active Expired - Lifetime
- 1970-01-20 SE SE00674/70A patent/SE358387B/xx unknown
- 1970-01-21 FR FR7002113A patent/FR2034483B1/fr not_active Expired
- 1970-01-21 IE IE80/70A patent/IE33953B1/xx unknown
- 1970-01-22 CA CA072847A patent/CA935152A/en not_active Expired
- 1970-01-22 BE BE744766D patent/BE744766A/xx not_active IP Right Cessation
- 1970-01-22 DK DK29470AA patent/DK123713B/da not_active IP Right Cessation
- 1970-01-23 AT AT64870A patent/AT300212B/de not_active IP Right Cessation
- 1970-01-23 NL NL7000977.A patent/NL160570C/xx not_active IP Right Cessation
- 1970-01-23 BR BR216251/70A patent/BR7016251D0/pt unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4001219A (en) * | 1975-02-13 | 1977-01-04 | Leandro Baiocchi | Steroidal derivatives of bendazolic acid and process for the preparation of the same |
Also Published As
| Publication number | Publication date |
|---|---|
| IE33953L (en) | 1970-07-23 |
| ES375613A1 (es) | 1972-10-16 |
| NO130476C (enExample) | 1974-12-18 |
| DE2001305A1 (de) | 1970-08-27 |
| DK123713B (da) | 1972-07-24 |
| FR2034483A1 (enExample) | 1970-12-11 |
| BE744766A (fr) | 1970-07-01 |
| CA935152A (en) | 1973-10-09 |
| FI47659C (fi) | 1974-02-11 |
| DE2001305B2 (de) | 1974-08-15 |
| FR2034483B1 (enExample) | 1974-02-01 |
| AT300212B (de) | 1972-07-25 |
| FI47659B (enExample) | 1973-10-31 |
| BR7016251D0 (pt) | 1973-01-25 |
| NL160570C (nl) | 1979-11-15 |
| SE358387B (enExample) | 1973-07-30 |
| NL160570B (nl) | 1979-06-15 |
| NL7000977A (enExample) | 1970-07-27 |
| DE2001305C3 (de) | 1975-05-07 |
| IE33953B1 (en) | 1974-12-30 |
| CH534143A (de) | 1973-02-28 |
| US3732260A (en) | 1973-05-08 |
| NO130476B (enExample) | 1974-09-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |