GB1269484A - Arylpyrazine and arylpyrimidine carboxylic acids and their derivatives - Google Patents

Arylpyrazine and arylpyrimidine carboxylic acids and their derivatives

Info

Publication number
GB1269484A
GB1269484A GB29539/70A GB2953970A GB1269484A GB 1269484 A GB1269484 A GB 1269484A GB 29539/70 A GB29539/70 A GB 29539/70A GB 2953970 A GB2953970 A GB 2953970A GB 1269484 A GB1269484 A GB 1269484A
Authority
GB
United Kingdom
Prior art keywords
reacting
amino
substituted
condensing
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB29539/70A
Other languages
English (en)
Inventor
Tsung-Ying Shen
Gordon Lyn Walford
Bruce Edward Witzel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1269484A publication Critical patent/GB1269484A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/34—One oxygen atom
    • C07D239/36—One oxygen atom as doubly bound oxygen atom or as unsubstituted hydroxy radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D241/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
GB29539/70A 1969-06-25 1970-06-18 Arylpyrazine and arylpyrimidine carboxylic acids and their derivatives Expired GB1269484A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US83664769A 1969-06-25 1969-06-25
US3029470A 1970-04-20 1970-04-20

Publications (1)

Publication Number Publication Date
GB1269484A true GB1269484A (en) 1972-04-06

Family

ID=26705875

Family Applications (1)

Application Number Title Priority Date Filing Date
GB29539/70A Expired GB1269484A (en) 1969-06-25 1970-06-18 Arylpyrazine and arylpyrimidine carboxylic acids and their derivatives

Country Status (7)

Country Link
BE (1) BE752456A (enExample)
CH (1) CH537390A (enExample)
DE (1) DE2031228A1 (enExample)
FR (1) FR2053012B1 (enExample)
GB (1) GB1269484A (enExample)
IL (1) IL34719A (enExample)
NL (1) NL7008625A (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0889038A1 (de) * 1997-07-03 1999-01-07 Lonza Ag Verfahren zur Herstellung von Alkoxy- oder Aryloxypyrazinderivaten
US7446117B2 (en) 2002-09-16 2008-11-04 Glaxo Group Limited Cox-2 inhibiting pyridine derivatives

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2201083A1 (en) * 1972-09-28 1974-04-26 Ferlux 6-Phenyl pyrimidine-4-carboxylic acids - analgesics, vasodilators, cardiac stimulants and respiratory analeptics
EP1501514B1 (en) * 2002-05-03 2012-12-19 Exelixis, Inc. Protein kinase modulators and methods of use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1121922A (en) * 1966-06-17 1968-07-31 Ici Ltd Pyrimidine derivatives

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0889038A1 (de) * 1997-07-03 1999-01-07 Lonza Ag Verfahren zur Herstellung von Alkoxy- oder Aryloxypyrazinderivaten
JPH1171354A (ja) * 1997-07-03 1999-03-16 Lonza Ag アルコキシピラジン誘導体の製造方法
US6066736A (en) * 1997-07-03 2000-05-23 Lonza Ag Process for preparing alkoxypyrazine derivatives
US6235905B1 (en) 1997-07-03 2001-05-22 Lonza Ag Process for preparing alkoxypyrazine derivatives
US6291674B2 (en) 1997-07-03 2001-09-18 Lonza Ag Process for preparing alkoxypyrazine derivatives
US7446117B2 (en) 2002-09-16 2008-11-04 Glaxo Group Limited Cox-2 inhibiting pyridine derivatives

Also Published As

Publication number Publication date
FR2053012A1 (enExample) 1971-04-16
IL34719A0 (en) 1970-08-19
NL7008625A (enExample) 1970-12-29
IL34719A (en) 1973-08-29
FR2053012B1 (enExample) 1974-05-24
BE752456A (fr) 1970-12-24
CH537390A (de) 1973-05-31
DE2031228A1 (de) 1971-01-28

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