GB1262830A - Novel sydnonimine derivative - Google Patents
Novel sydnonimine derivativeInfo
- Publication number
- GB1262830A GB1262830A GB2810170A GB2810170A GB1262830A GB 1262830 A GB1262830 A GB 1262830A GB 2810170 A GB2810170 A GB 2810170A GB 2810170 A GB2810170 A GB 2810170A GB 1262830 A GB1262830 A GB 1262830A
- Authority
- GB
- United Kingdom
- Prior art keywords
- methylphenethyl
- imine
- phenylcarbamoyl
- novel
- novel compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- GSKDBLIBBOYOFU-UHFFFAOYSA-N oxadiazol-5-amine Chemical class NC1=CN=NO1 GSKDBLIBBOYOFU-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 2
- OWFUPROYPKGHMH-UHFFFAOYSA-N n-phenyl-n'-[3-(1-phenylpropan-2-yl)oxadiazol-3-ium-5-yl]carbamimidate Chemical compound C1=C(N=C([O-])NC=2C=CC=CC=2)ON=[N+]1C(C)CC1=CC=CC=C1 OWFUPROYPKGHMH-UHFFFAOYSA-N 0.000 abstract 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 abstract 1
- 210000003169 central nervous system Anatomy 0.000 abstract 1
- 239000003085 diluting agent Substances 0.000 abstract 1
- -1 imine hydrochloride Chemical class 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- DGTNSSLYPYDJGL-UHFFFAOYSA-N phenyl isocyanate Chemical compound O=C=NC1=CC=CC=C1 DGTNSSLYPYDJGL-UHFFFAOYSA-N 0.000 abstract 1
- 239000002798 polar solvent Substances 0.000 abstract 1
- 235000017281 sodium acetate Nutrition 0.000 abstract 1
- 239000001632 sodium acetate Substances 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/04—1,2,3-Oxadiazoles; Hydrogenated 1,2,3-oxadiazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Hydrogenated Pyridines (AREA)
Abstract
1,262,830. 3-(α-Methylphenethyl)-N-(phenylcarbamoyl)-sydnone imine. VSESOJUZNY NAUCHNO-ISSLEDOVATELSKY KHIMIKO-FARMATSEVTICHESKY INSTITUT IMENI S. ORDZHONIKIDZE. 10 June, 1970, No. 28101/70. Heading C2L. The novel compound, 3-(α-methylphenethyl)- N-(phenylcarbamoyl)-sydnone imine, is obtained by reacting 3-(α-methylphenethyl)-syndone imine hydrochloride with phenyl isocyanate in a polar solvent in the presence of sodium acetate. Pharmaceutical compositions, having a stimulating effect on the central nervous system and suitable for oral administration, contain the above novel compound and pharmaceutically acceptable diluents.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2810170A GB1262830A (en) | 1970-06-10 | 1970-06-10 | Novel sydnonimine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB2810170A GB1262830A (en) | 1970-06-10 | 1970-06-10 | Novel sydnonimine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1262830A true GB1262830A (en) | 1972-02-09 |
Family
ID=10270292
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB2810170A Expired GB1262830A (en) | 1970-06-10 | 1970-06-10 | Novel sydnonimine derivative |
Country Status (1)
Country | Link |
---|---|
GB (1) | GB1262830A (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4245100A (en) | 1977-11-28 | 1981-01-13 | Vsesojuzny Nauchno-Issledovatelsky Khimikofarmatsevtichesky Institut Imeni S. Ordzhonikidze | Sydnonimine N-acyl derivatives and method for preparing same |
EP0050916A3 (en) * | 1980-10-02 | 1982-06-02 | American Home Products Corporation | Cns stimulants and antihypertensive agents |
US8415385B2 (en) | 2007-03-14 | 2013-04-09 | Hao Chen | Sydnonimines-specific dopamine reuptake inhibitors and their use in treating dopamine related disorders |
US8691853B2 (en) | 2007-03-14 | 2014-04-08 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating autoimmune conditions and delaying or preventing autoimmune related pathologic progressions |
WO2014145126A2 (en) | 2013-03-15 | 2014-09-18 | Melior Discovery, Inc. | Methods of treating dyskinesia and related disorders |
US9119843B2 (en) | 2009-12-04 | 2015-09-01 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions |
-
1970
- 1970-06-10 GB GB2810170A patent/GB1262830A/en not_active Expired
Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4245100A (en) | 1977-11-28 | 1981-01-13 | Vsesojuzny Nauchno-Issledovatelsky Khimikofarmatsevtichesky Institut Imeni S. Ordzhonikidze | Sydnonimine N-acyl derivatives and method for preparing same |
EP0050916A3 (en) * | 1980-10-02 | 1982-06-02 | American Home Products Corporation | Cns stimulants and antihypertensive agents |
US8415385B2 (en) | 2007-03-14 | 2013-04-09 | Hao Chen | Sydnonimines-specific dopamine reuptake inhibitors and their use in treating dopamine related disorders |
US8691853B2 (en) | 2007-03-14 | 2014-04-08 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating autoimmune conditions and delaying or preventing autoimmune related pathologic progressions |
US9149466B2 (en) | 2007-03-14 | 2015-10-06 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating autoimmune conditions and delaying or preventing autoimmune related pathologic progressions |
US9604945B2 (en) | 2007-03-14 | 2017-03-28 | Caliper Life Sciences, Inc. | Sydnonimines-specific dopamine reuptake inhibitors and their use in treating dopamine related disorders |
US9119843B2 (en) | 2009-12-04 | 2015-09-01 | Caliper Life Sciences, Inc. | Method of using dopamine reuptake inhibitors and their analogs for treating diabetes symptoms and delaying or preventing diabetes-associated pathologic conditions |
WO2014145126A2 (en) | 2013-03-15 | 2014-09-18 | Melior Discovery, Inc. | Methods of treating dyskinesia and related disorders |
US12048697B2 (en) | 2013-03-15 | 2024-07-30 | Melior Pharmaceuticals Ii, Llc | Methods of treating dyskinesia and related disorders |
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