ES475659A1 - Cephalospoline compound and process for preparing same - Google Patents

Cephalospoline compound and process for preparing same

Info

Publication number
ES475659A1
ES475659A1 ES475659A ES475659A ES475659A1 ES 475659 A1 ES475659 A1 ES 475659A1 ES 475659 A ES475659 A ES 475659A ES 475659 A ES475659 A ES 475659A ES 475659 A1 ES475659 A1 ES 475659A1
Authority
ES
Spain
Prior art keywords
alkyl
new
cephalospoline
compound
preparing same
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES475659A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB48719/75A external-priority patent/GB1570582A/en
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES475659A1 publication Critical patent/ES475659A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/10—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles
    • C07D271/113—1,3,4-Oxadiazoles; Hydrogenated 1,3,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/36—Methylene radicals, substituted by sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Cephalosporins of formula (I) and their pharmaceutically acceptable salts and esters are new (R = organic acylamino, Y = N-contg. 5-membered ring. n = 0 or 1. R1 and R2 are H or 1-6C alkyl. R3 and R4 are each 1-3C alkyl or together they complete a monocyclic ring). Also new are the intermediates of formulae (VI) and (IXA) (where Rx = H or a blocking gp. m = 0 or 1. The dotted line is a double bond at 2 or 3 posn.). Cpds. (I) are antibacterials for use in human or veterinary medicine and are administered in usual oral, topical or parenteral forms e.g. unit doses of 50-500 mg for an adult human dose of 0.1-3 g/day. They are pref. used together with clavulanic acid or its derivs. A typical cpd. is 7- D-alpha-(3-benzoyl-3-methylureido) phenylacetamido -3-(2-carbamoylmethyl-1,3,4-oxadiazol-5-ylthio) methylceph-3-em-4-carboxylic acid/.
ES475659A 1975-11-27 1978-12-01 Cephalospoline compound and process for preparing same Expired ES475659A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB48719/75A GB1570582A (en) 1975-11-27 1975-11-27 Cephalosporins
GB1495276 1976-04-13

Publications (1)

Publication Number Publication Date
ES475659A1 true ES475659A1 (en) 1979-10-16

Family

ID=26250914

Family Applications (2)

Application Number Title Priority Date Filing Date
ES453722A Expired ES453722A1 (en) 1975-11-27 1976-11-26 Cephalospoline compound and process for preparing same
ES475659A Expired ES475659A1 (en) 1975-11-27 1978-12-01 Cephalospoline compound and process for preparing same

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES453722A Expired ES453722A1 (en) 1975-11-27 1976-11-26 Cephalospoline compound and process for preparing same

Country Status (14)

Country Link
JP (1) JPS5278894A (en)
AU (1) AU2008776A (en)
DE (1) DE2653621A1 (en)
DK (1) DK536176A (en)
ES (2) ES453722A1 (en)
FI (1) FI763363A (en)
FR (1) FR2332757A1 (en)
GR (1) GR61821B (en)
IL (1) IL50945A0 (en)
NL (1) NL7613243A (en)
NO (1) NO764034L (en)
NZ (1) NZ182649A (en)
PH (1) PH13321A (en)
SE (1) SE7613150L (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4278670A (en) * 1976-07-12 1981-07-14 Smithkline Corporation 7-Alpha-oxyiminoacylcephalosporins
CA1115267A (en) * 1976-08-30 1981-12-29 William J. Gottstein 7-(2-alkyloxyimino-2-furylacetamido)-3-(1- carboxyalkyltetrazolyl-5-thiomethyl)-3-cephem-4- carboxylic acid)
JPS53155051U (en) * 1977-05-10 1978-12-06
JPS54106495A (en) * 1978-02-09 1979-08-21 Dai Ichi Seiyaku Co Ltd Cephem derivative
DK225179A (en) 1978-06-22 1979-12-23 Chugai Pharmaceutical Co Ltd PROCEDURE FOR PREPARING CEPHALOSPORINE DERIVATIVES

Also Published As

Publication number Publication date
FI763363A (en) 1977-05-28
AU2008776A (en) 1978-06-08
IL50945A0 (en) 1977-01-31
NZ182649A (en) 1979-11-01
DE2653621A1 (en) 1977-06-08
ES453722A1 (en) 1979-06-01
JPS5278894A (en) 1977-07-02
SE7613150L (en) 1977-05-28
NO764034L (en) 1977-05-31
GR61821B (en) 1979-01-22
DK536176A (en) 1977-05-28
NL7613243A (en) 1977-06-01
FR2332757A1 (en) 1977-06-24
PH13321A (en) 1980-03-13

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