GB1260893A - 2-hydroxypropylamine derivatives, their preparation and pharmaceutical compositions containing them - Google Patents
2-hydroxypropylamine derivatives, their preparation and pharmaceutical compositions containing themInfo
- Publication number
- GB1260893A GB1260893A GB40830/69A GB4083069A GB1260893A GB 1260893 A GB1260893 A GB 1260893A GB 40830/69 A GB40830/69 A GB 40830/69A GB 4083069 A GB4083069 A GB 4083069A GB 1260893 A GB1260893 A GB 1260893A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- compounds
- formula
- aryl
- pharmaceutical compositions
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
1,260,893. Urea derivatives. PFIZER Ltd. 13 Aug., 1970 [15 Aug., 1969], No. 40830/69. Heading C2C. The invention comprises novel urea derivatives of the formula wherein R is a ureido group; R<SP>1</SP> is H, halogen or C 1-6 -alkyl; R<SP>2</SP> is H or C 1-6 alkyl; R<SP>3</SP> is H, C 1-6 alkyl or aryl-C 1-6 alkyl ; R<SP>4</SP> is C 1-6 alkyl, hydroxy- C 1-6 alkyl, C 1-6 alkoxy-C 1-6 alkyl, aryloxy-C 1-6 alkyl, cycloalkyl; C 2-6 alkenyl or aryl-C 1-6 alkyl; and X is O or S ; the esters of compounds having free hydroxy groups; the aldehyde condensation products of compounds in which R<SP>2</SP> and R<SP>3</SP> are each hydrogen; the N-oxides of compounds in which R<SP>3</SP> is not hydrogen; and pharmaceutically acceptable acid addition salts thereof. The novel compounds are prepared by reacting the appropriate epoxides or chlorohydrins or ethers thereof of the formulµ with amines of the formula or by reacting propanolamines of the formula with aldehydes or ketones of the formula and reducing the products to give compounds in which R<SP>3</SP> is H and R<SP>4</SP> is CHR<SP>9</SP>R<SP>10</SP>, or a cycloalkyl group, R<SP>9</SP> being C 1-5 alkyl, which may be substituted by OH 1 C 1-6 alkoxy, aryloxy or aryl, and R<SP>10</SP> being H or C 1-4 alkyl, the alkyl groups of R<SP>9</SP> and R<SP>10</SP> together not containing more than S carbon atoms, or R<SP>4</SP> and R<SP>10</SP> together with carbon atom to which they are attached forming a cycloalkylidene group. Pharmaceutical compositions, suitable for oral or parenteral administration, contain the above novel compounds and pharmaceutically acceptable carriers. The compounds have anti-hypertensive activity and/or the ability to block the #-adrenergic receptors,
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB40830/69A GB1260893A (en) | 1969-08-15 | 1969-08-15 | 2-hydroxypropylamine derivatives, their preparation and pharmaceutical compositions containing them |
BR215086/69A BR6915086D0 (en) | 1969-08-15 | 1969-12-15 | THERAPEUTIC AGENTS |
FR7030098A FR2068502B1 (en) | 1969-08-15 | 1970-08-14 | |
DE19702040441 DE2040441A1 (en) | 1969-08-15 | 1970-08-14 | New phenyloxy and phenylthiopropylamines |
JP45071317A JPS4935260B1 (en) | 1969-08-15 | 1970-08-15 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB40830/69A GB1260893A (en) | 1969-08-15 | 1969-08-15 | 2-hydroxypropylamine derivatives, their preparation and pharmaceutical compositions containing them |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1260893A true GB1260893A (en) | 1972-01-19 |
Family
ID=10416847
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB40830/69A Expired GB1260893A (en) | 1969-08-15 | 1969-08-15 | 2-hydroxypropylamine derivatives, their preparation and pharmaceutical compositions containing them |
Country Status (5)
Country | Link |
---|---|
JP (1) | JPS4935260B1 (en) |
BR (1) | BR6915086D0 (en) |
DE (1) | DE2040441A1 (en) |
FR (1) | FR2068502B1 (en) |
GB (1) | GB1260893A (en) |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4035420A (en) | 1972-07-06 | 1977-07-12 | Aktiebolaget Hassle | Substituted ureido alkylene phenoxy propanolamines |
US4145363A (en) | 1975-02-05 | 1979-03-20 | Yamanouchi Pharmaceutical Co., Ltd. | 4-Carbamoylamino-α-aminomethylbenzyl alcohol derivatives |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4038313A (en) * | 1970-01-08 | 1977-07-26 | Ciba-Geigy Corporation | Cycloalkylureido phenoxy propanolamines |
-
1969
- 1969-08-15 GB GB40830/69A patent/GB1260893A/en not_active Expired
- 1969-12-15 BR BR215086/69A patent/BR6915086D0/en unknown
-
1970
- 1970-08-14 FR FR7030098A patent/FR2068502B1/fr not_active Expired
- 1970-08-14 DE DE19702040441 patent/DE2040441A1/en active Pending
- 1970-08-15 JP JP45071317A patent/JPS4935260B1/ja active Pending
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4035420A (en) | 1972-07-06 | 1977-07-12 | Aktiebolaget Hassle | Substituted ureido alkylene phenoxy propanolamines |
US4145363A (en) | 1975-02-05 | 1979-03-20 | Yamanouchi Pharmaceutical Co., Ltd. | 4-Carbamoylamino-α-aminomethylbenzyl alcohol derivatives |
Also Published As
Publication number | Publication date |
---|---|
BR6915086D0 (en) | 1973-03-08 |
FR2068502B1 (en) | 1974-08-30 |
DE2040441A1 (en) | 1971-02-25 |
JPS4935260B1 (en) | 1974-09-20 |
FR2068502A1 (en) | 1971-08-27 |
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