GB1253741A - A process for the manufacture of quinoline derivatives - Google Patents
A process for the manufacture of quinoline derivativesInfo
- Publication number
- GB1253741A GB1253741A GB33311/69A GB3331169A GB1253741A GB 1253741 A GB1253741 A GB 1253741A GB 33311/69 A GB33311/69 A GB 33311/69A GB 3331169 A GB3331169 A GB 3331169A GB 1253741 A GB1253741 A GB 1253741A
- Authority
- GB
- United Kingdom
- Prior art keywords
- propionic acid
- chloro
- ethyl ester
- benzoyl
- compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940027991 antiseptic and disinfectant quinoline derivative Drugs 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 125000002943 quinolinyl group Chemical class N1=C(C=CC2=CC=CC=C12)* 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 11
- FKRCODPIKNYEAC-UHFFFAOYSA-N ethyl propionate Chemical compound CCOC(=O)CC FKRCODPIKNYEAC-UHFFFAOYSA-N 0.000 abstract 10
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229920002554 vinyl polymer Polymers 0.000 abstract 5
- 239000002253 acid Substances 0.000 abstract 4
- 150000003839 salts Chemical class 0.000 abstract 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 3
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 abstract 3
- 125000001340 2-chloroethyl group Chemical group [H]C([H])(Cl)C([H])([H])* 0.000 abstract 2
- 125000003342 alkenyl group Chemical group 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- -1 methylenedioxy Chemical group 0.000 abstract 2
- 150000003248 quinolines Chemical class 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 230000000078 anti-malarial effect Effects 0.000 abstract 1
- 239000003430 antimalarial agent Substances 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
- C07D453/04—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems having a quinolyl-4, a substituted quinolyl-4 or a alkylenedioxy-quinolyl-4 radical linked through only one carbon atom, attached in position 2, e.g. quinine
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US74191368A | 1968-07-02 | 1968-07-02 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1253741A true GB1253741A (en) | 1971-11-17 |
Family
ID=24982727
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB33311/69A Expired GB1253741A (en) | 1968-07-02 | 1969-07-02 | A process for the manufacture of quinoline derivatives |
Country Status (14)
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030044A1 (en) * | 1979-11-01 | 1981-06-10 | Acf Chemiefarma Nv | Quinoline derivatives, processes for their preparation, their use, pharmaceutical compositions containing them and a method for the preparation of these pharmaceutical compositions |
| US7232834B2 (en) | 2002-09-11 | 2007-06-19 | Novexel Sa | Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH590275A5 (enrdf_load_stackoverflow) * | 1970-03-16 | 1977-07-29 | Hoffmann La Roche | |
| GB1441244A (en) * | 1972-11-17 | 1976-06-30 | Rech Et Dapplications Scient S | Derivatives of quinoline and method of preparing the same |
| AU2011202542A1 (en) | 2010-07-14 | 2012-02-02 | Indian Institute Of Science | Benzothiophene carboxamide compounds, composition and applications thereof |
-
1969
- 1969-06-26 CH CH1402971A patent/CH533123A/de not_active IP Right Cessation
- 1969-06-26 CH CH977369A patent/CH521975A/de not_active IP Right Cessation
- 1969-07-01 FR FR6922135A patent/FR2012151A1/fr not_active Withdrawn
- 1969-07-01 AT AT626969A patent/AT319481B/de not_active IP Right Cessation
- 1969-07-01 BE BE735450D patent/BE735450A/xx not_active IP Right Cessation
- 1969-07-02 DK DK359169AA patent/DK136069B/da not_active IP Right Cessation
- 1969-07-02 GB GB33311/69A patent/GB1253741A/en not_active Expired
- 1969-07-02 IE IE903/69A patent/IE33474B1/xx unknown
- 1969-07-02 CA CA055,885A patent/CA956312A/en not_active Expired
- 1969-07-02 SE SE941269A patent/SE367823B/xx unknown
- 1969-07-02 NL NL6910144.A patent/NL166475C/xx not_active IP Right Cessation
- 1969-07-02 DE DE19691933599 patent/DE1933599A1/de not_active Ceased
- 1969-07-02 DE DE1967178A patent/DE1967178C2/de not_active Expired
- 1969-07-02 SE SE7206590A patent/SE375775B/xx unknown
- 1969-07-02 IL IL32534A patent/IL32534A/xx unknown
-
1971
- 1971-01-21 AT AT49171A patent/AT341115B/de not_active IP Right Cessation
- 1971-06-04 JP JP46039235A patent/JPS4915278B1/ja active Pending
- 1971-06-23 DK DK308971AA patent/DK136982B/da unknown
- 1971-11-01 CA CA126,551A patent/CA962682A/en not_active Expired
- 1971-12-16 PH PH13115A patent/PH12608A/en unknown
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0030044A1 (en) * | 1979-11-01 | 1981-06-10 | Acf Chemiefarma Nv | Quinoline derivatives, processes for their preparation, their use, pharmaceutical compositions containing them and a method for the preparation of these pharmaceutical compositions |
| US7232834B2 (en) | 2002-09-11 | 2007-06-19 | Novexel Sa | Quinolylpropylpiperidine derivatives, intermediates and compositions containing them, and preparation therefor |
Also Published As
| Publication number | Publication date |
|---|---|
| IE33474L (en) | 1970-01-02 |
| NL6910144A (enrdf_load_stackoverflow) | 1970-01-06 |
| DK136982B (da) | 1977-12-27 |
| DE1967178C2 (de) | 1984-11-22 |
| IL32534A0 (en) | 1969-09-25 |
| NL166475B (nl) | 1981-03-16 |
| FR2012151A1 (enrdf_load_stackoverflow) | 1970-03-13 |
| DK136982C (enrdf_load_stackoverflow) | 1978-07-10 |
| CH533123A (de) | 1973-01-31 |
| IL32534A (en) | 1975-07-28 |
| DK136069C (enrdf_load_stackoverflow) | 1978-01-16 |
| AT319481B (de) | 1974-12-27 |
| AT341115B (de) | 1978-01-25 |
| CA962682A (en) | 1975-02-11 |
| NL166475C (nl) | 1981-08-17 |
| DE1933599A1 (de) | 1970-02-26 |
| ATA49171A (de) | 1977-05-15 |
| SE375775B (enrdf_load_stackoverflow) | 1975-04-28 |
| IE33474B1 (en) | 1974-07-10 |
| CA956312A (en) | 1974-10-15 |
| JPS4915278B1 (enrdf_load_stackoverflow) | 1974-04-13 |
| SE367823B (enrdf_load_stackoverflow) | 1974-06-10 |
| CH521975A (de) | 1972-04-30 |
| PH12608A (en) | 1979-06-27 |
| BE735450A (enrdf_load_stackoverflow) | 1970-01-02 |
| DK136069B (da) | 1977-08-08 |
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