GB1249047A - Phenylbutazone derivatives and their preparation - Google Patents
Phenylbutazone derivatives and their preparationInfo
- Publication number
- GB1249047A GB1249047A GB5747469A GB5747469A GB1249047A GB 1249047 A GB1249047 A GB 1249047A GB 5747469 A GB5747469 A GB 5747469A GB 5747469 A GB5747469 A GB 5747469A GB 1249047 A GB1249047 A GB 1249047A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formula
- phenylbutazone
- molecules
- pharmaceutically acceptable
- nov
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D231/28—Two oxygen or sulfur atoms
- C07D231/30—Two oxygen or sulfur atoms attached in positions 3 and 5
- C07D231/32—Oxygen atoms
- C07D231/36—Oxygen atoms with hydrocarbon radicals, substituted by hetero atoms, attached in position 4
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
1,249,047. Phenylbutazone derivatives. DAUSSE S.A. 24 Nov., 1969 [25 Nov., 1968; 19 Feb., 1969], No. 57474/69. Heading C2C. Novel compounds of Formula I in which n is 1 or 2 and B is a monovalent or divalent radical of a saturated, heterocyclic, secondary, mono- or di-amine, the heterocyclic structure containing one or more hetero atoms, and being bonded to the CH 2 group of the formula by a nitrogen atom, B being other than piperidino or morpholino, and their pharmaceutically acceptable acid addition salts, are prepared by (a) reacting n molecules of phenylbutazone and n molecules of formaldehyde with one molecule of an amine of formula B(H) n , or (b) reacting n molecules of phenylbutazone with one molecule of an aminoether of formula B(CH 2 OC 2 H 5 ) n in the cold, and, if desired, forming a pharmaceutically acceptable acid addition salt of a resulting compound I. Pharmaceutical compositions having antiinflammatory, analgesic and antipyretic properties, for oral, rectal or topical administration, comprise a compound of Formula I or a pharmaceutically acceptable addition salt thereof.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR175144 | 1968-11-25 | ||
FR6983257 | 1969-02-19 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1249047A true GB1249047A (en) | 1971-10-06 |
Family
ID=26182329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB5747469A Expired GB1249047A (en) | 1968-11-25 | 1969-11-24 | Phenylbutazone derivatives and their preparation |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE741859A (en) |
CH (1) | CH507251A (en) |
GB (1) | GB1249047A (en) |
NL (1) | NL146048B (en) |
-
1969
- 1969-11-18 NL NL6917316A patent/NL146048B/en unknown
- 1969-11-18 BE BE741859D patent/BE741859A/xx not_active IP Right Cessation
- 1969-11-21 CH CH1737669A patent/CH507251A/en not_active IP Right Cessation
- 1969-11-24 GB GB5747469A patent/GB1249047A/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
NL146048B (en) | 1975-06-16 |
DE1958722A1 (en) | 1970-05-21 |
BE741859A (en) | 1970-05-04 |
NL6917316A (en) | 1970-05-27 |
CH507251A (en) | 1971-05-15 |
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