GB1236955A - Preparation of (cis-1,2-epoxypropyl)phosphonic acid and salts thereof - Google Patents

Preparation of (cis-1,2-epoxypropyl)phosphonic acid and salts thereof

Info

Publication number
GB1236955A
GB1236955A GB23137/68A GB2313768A GB1236955A GB 1236955 A GB1236955 A GB 1236955A GB 23137/68 A GB23137/68 A GB 23137/68A GB 2313768 A GB2313768 A GB 2313768A GB 1236955 A GB1236955 A GB 1236955A
Authority
GB
United Kingdom
Prior art keywords
cis
acid
epoxypropyl
formula
ester
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB23137/68A
Other languages
English (en)
Inventor
Meyer Sletzinger
Seemon H Pines
Edward J Glamkowski
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to GB23137/68A priority Critical patent/GB1236955A/en
Priority to NL6814982A priority patent/NL6814982A/xx
Priority to IL6830914A priority patent/IL30914A0/xx
Priority to BR203535/68A priority patent/BR6803535D0/pt
Priority to LU57190D priority patent/LU57190A1/xx
Priority to ZM141/68A priority patent/ZM14168A1/xx
Priority to OA53406A priority patent/OA02916A/xx
Priority to MT588A priority patent/MTP588B/xx
Priority to IE59769A priority patent/IE32881B1/xx
Priority to IL32112A priority patent/IL32112A0/xx
Priority to BE732673D priority patent/BE732673A/xx
Priority to DE19691923544 priority patent/DE1923544A1/de
Priority to CH743169A priority patent/CH554378A/xx
Priority to NL6907461A priority patent/NL6907461A/xx
Priority to AT463869A priority patent/AT309464B/de
Priority to ES367268A priority patent/ES367268A1/es
Priority to BR208793/69A priority patent/BR6908793D0/pt
Priority to HUME1078A priority patent/HU163585B/hu
Priority to FR6915926A priority patent/FR2011837A1/fr
Publication of GB1236955A publication Critical patent/GB1236955A/en
Priority to ES395154A priority patent/ES395154A1/es
Priority to ES395156A priority patent/ES395156A1/es
Priority to ES71395159A priority patent/ES395159A1/es
Priority to ES395160A priority patent/ES395160A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/65502—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a three-membered ring
    • C07F9/65505—Phosphonic acids containing oxirane groups; esters thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/657163—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom
    • C07F9/657181—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms the ring phosphorus atom being bound to at least one carbon atom the ring phosphorus atom and, at least, one ring oxygen atom being part of a (thio)phosphonic acid derivative
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J3/00—Circuit arrangements for AC mains or AC distribution networks
    • H02J3/38—Arrangements for parallely feeding a single network by two or more generators, converters or transformers
    • H02J3/381—Dispersed generators
    • H—ELECTRICITY
    • H02—GENERATION; CONVERSION OR DISTRIBUTION OF ELECTRIC POWER
    • H02J—CIRCUIT ARRANGEMENTS OR SYSTEMS FOR SUPPLYING OR DISTRIBUTING ELECTRIC POWER; SYSTEMS FOR STORING ELECTRIC ENERGY
    • H02J2300/00—Systems for supplying or distributing electric power characterised by decentralized, dispersed, or local generation
    • H02J2300/20—The dispersed energy generation being of renewable origin
    • H02J2300/28—The renewable source being wind energy

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Power Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
GB23137/68A 1968-05-15 1968-05-15 Preparation of (cis-1,2-epoxypropyl)phosphonic acid and salts thereof Expired GB1236955A (en)

Priority Applications (23)

Application Number Priority Date Filing Date Title
GB23137/68A GB1236955A (en) 1968-05-15 1968-05-15 Preparation of (cis-1,2-epoxypropyl)phosphonic acid and salts thereof
NL6814982A NL6814982A (enExample) 1968-05-15 1968-10-18
IL6830914A IL30914A0 (en) 1968-05-15 1968-10-21 Processes for the preparation of phosphonic acids and salts thereof
BR203535/68A BR6803535D0 (pt) 1968-05-15 1968-10-29 Processo para a producao de antibioticos
LU57190D LU57190A1 (enExample) 1968-05-15 1968-10-29
ZM141/68A ZM14168A1 (en) 1968-05-15 1968-10-30 Process for production of antibiotics
OA53406A OA02916A (fr) 1968-05-15 1968-10-30 Procédé de fabrication d'antibiotiques plus particulièrement l'acide (cis-1,2-époxypropyl) phosphonique et de ses sels.
MT588A MTP588B (en) 1968-05-15 1968-11-22 Chemical process (process for production of intibiotics
IE59769A IE32881B1 (en) 1968-05-15 1969-04-29 Preparation of (cis-1,2-epoxypropyl)phosphonic acid and salts thereof
IL32112A IL32112A0 (en) 1968-05-15 1969-04-30 Methods for making phosphonates
BE732673D BE732673A (enExample) 1968-05-15 1969-05-07
DE19691923544 DE1923544A1 (de) 1968-05-15 1969-05-08 Verfahren zum Herstellen von Phosphonaten
CH743169A CH554378A (de) 1968-05-15 1969-05-14 Verfahren zur herstellung von (cis-1,2-epoxypropyl)phosphonsaeure bzw.- phosphonsaeure sowie deren salze.
NL6907461A NL6907461A (enExample) 1968-05-15 1969-05-14
AT463869A AT309464B (de) 1968-05-15 1969-05-14 Verfahren zur Herstellung der neuen (cis-1,2-Epoxypropyl)-phosphosäure oder eines Salzes dieser Säure
ES367268A ES367268A1 (es) 1968-05-15 1969-05-14 Un procedimiento para la obtencion de acidos fosfonicos o sus sales.
BR208793/69A BR6908793D0 (pt) 1968-05-15 1969-05-14 Processo para a producao de fosfanatos
HUME1078A HU163585B (enExample) 1968-05-15 1969-05-15
FR6915926A FR2011837A1 (enExample) 1968-05-15 1969-05-16
ES395154A ES395154A1 (es) 1968-05-15 1971-09-16 Un procedimiento para la obtencion de acidos fosfonicos o sus sales.
ES395156A ES395156A1 (es) 1968-05-15 1971-09-16 Un procedimiento para la obtencion de acidos fosfonicos o sus sales.
ES71395159A ES395159A1 (es) 1968-05-15 1971-09-16 Un procedimiento para la obtencion de acidos fosfonicos o sus sales.
ES395160A ES395160A1 (es) 1968-05-15 1971-09-16 Un procedimiento para la obtencion de acidos fosfonicos o sus sales.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB23137/68A GB1236955A (en) 1968-05-15 1968-05-15 Preparation of (cis-1,2-epoxypropyl)phosphonic acid and salts thereof

Publications (1)

Publication Number Publication Date
GB1236955A true GB1236955A (en) 1971-06-23

Family

ID=10190752

Family Applications (1)

Application Number Title Priority Date Filing Date
GB23137/68A Expired GB1236955A (en) 1968-05-15 1968-05-15 Preparation of (cis-1,2-epoxypropyl)phosphonic acid and salts thereof

Country Status (15)

Country Link
AT (1) AT309464B (enExample)
BE (1) BE732673A (enExample)
BR (2) BR6803535D0 (enExample)
CH (1) CH554378A (enExample)
DE (1) DE1923544A1 (enExample)
ES (5) ES367268A1 (enExample)
FR (1) FR2011837A1 (enExample)
GB (1) GB1236955A (enExample)
HU (1) HU163585B (enExample)
IL (2) IL30914A0 (enExample)
LU (1) LU57190A1 (enExample)
MT (1) MTP588B (enExample)
NL (2) NL6814982A (enExample)
OA (1) OA02916A (enExample)
ZM (1) ZM14168A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117964661A (zh) * 2024-04-01 2024-05-03 深圳创元生物医药科技有限公司 一种磷霉素基因毒杂质c的制备方法

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3635795A (en) * 1968-12-27 1972-01-18 Merck & Co Inc Enzymatic resolution of racemic (cis-1,2-epoxypropyl) phosphonic acid compounds
IT1042192B (it) * 1975-08-29 1980-01-30 Italchemi Spa Sintesi di acidi epossialchilfo sfonici
US20230219817A1 (en) * 2020-06-16 2023-07-13 Yara International Asa Process for the removal of heavy metals from a phosphoric acid containing composition

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117964661A (zh) * 2024-04-01 2024-05-03 深圳创元生物医药科技有限公司 一种磷霉素基因毒杂质c的制备方法
CN117964661B (zh) * 2024-04-01 2024-06-07 深圳创元生物医药科技有限公司 一种磷霉素基因毒杂质c的制备方法

Also Published As

Publication number Publication date
NL6907461A (enExample) 1969-11-18
CH554378A (de) 1974-09-30
BR6803535D0 (pt) 1973-02-22
DE1923544A1 (de) 1970-08-27
MTP588B (en) 1970-10-23
OA02916A (fr) 1970-12-15
HU163585B (enExample) 1973-09-27
FR2011837A1 (enExample) 1970-03-13
ZM14168A1 (en) 1970-06-18
ES395154A1 (es) 1973-12-16
BE732673A (enExample) 1969-11-07
BR6908793D0 (pt) 1973-05-10
ES395159A1 (es) 1974-01-01
ES395160A1 (es) 1974-01-01
IL32112A0 (en) 1969-06-25
ES395156A1 (es) 1974-01-01
ES367268A1 (es) 1972-03-16
NL6814982A (enExample) 1969-11-18
LU57190A1 (enExample) 1969-05-16
IL30914A0 (en) 1968-12-26
AT309464B (de) 1973-08-27

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