GB1236801A - PROCESS FOR THE MANUFACTURE OF alpha-THYROCALCITONIN AND &beta-THYROCALCITONIN - Google Patents
PROCESS FOR THE MANUFACTURE OF alpha-THYROCALCITONIN AND &beta-THYROCALCITONINInfo
- Publication number
- GB1236801A GB1236801A GB2389768A GB2389768A GB1236801A GB 1236801 A GB1236801 A GB 1236801A GB 2389768 A GB2389768 A GB 2389768A GB 2389768 A GB2389768 A GB 2389768A GB 1236801 A GB1236801 A GB 1236801A
- Authority
- GB
- United Kingdom
- Prior art keywords
- thyrocalcitonin
- asn
- ser
- phe
- leu
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 abstract 6
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 abstract 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 abstract 2
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical compound C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 abstract 2
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N formic acid Substances OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 239000002904 solvent Substances 0.000 abstract 2
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 abstract 2
- 229960004319 trichloroacetic acid Drugs 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- QEFRNWWLZKMPFJ-YGVKFDHGSA-N L-methionine S-oxide Chemical group CS(=O)CC[C@H](N)C(O)=O QEFRNWWLZKMPFJ-YGVKFDHGSA-N 0.000 abstract 1
- KZNQNBZMBZJQJO-UHFFFAOYSA-N N-glycyl-L-proline Natural products NCC(=O)N1CCCC1C(O)=O KZNQNBZMBZJQJO-UHFFFAOYSA-N 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 abstract 1
- 229960000583 acetic acid Drugs 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000000502 dialysis Methods 0.000 abstract 1
- 238000001962 electrophoresis Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 230000008020 evaporation Effects 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 238000004108 freeze drying Methods 0.000 abstract 1
- 238000005227 gel permeation chromatography Methods 0.000 abstract 1
- 239000012362 glacial acetic acid Substances 0.000 abstract 1
- 108010077435 glycyl-phenylalanyl-glycine Proteins 0.000 abstract 1
- 238000005342 ion exchange Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 238000001556 precipitation Methods 0.000 abstract 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
- 239000001117 sulphuric acid Substances 0.000 abstract 1
- 238000004809 thin layer chromatography Methods 0.000 abstract 1
- 210000001685 thyroid gland Anatomy 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/23—Calcitonins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/585—Calcitonins
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Endocrinology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Epidemiology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH734667 | 1967-05-24 | ||
| CH995067 | 1967-07-12 | ||
| CH115968 | 1968-01-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1236801A true GB1236801A (en) | 1971-06-23 |
Family
ID=27172746
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2389768A Expired GB1236801A (en) | 1967-05-24 | 1968-05-20 | PROCESS FOR THE MANUFACTURE OF alpha-THYROCALCITONIN AND &beta-THYROCALCITONIN |
Country Status (7)
| Country | Link |
|---|---|
| BE (1) | BE715572A (enrdf_load_stackoverflow) |
| CA (1) | CA919590A (enrdf_load_stackoverflow) |
| CY (1) | CY753A (enrdf_load_stackoverflow) |
| DE (1) | DE1767477C3 (enrdf_load_stackoverflow) |
| FR (2) | FR1576527A (enrdf_load_stackoverflow) |
| GB (1) | GB1236801A (enrdf_load_stackoverflow) |
| NL (1) | NL6807271A (enrdf_load_stackoverflow) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1950711A1 (de) * | 1968-10-15 | 1970-04-30 | Ciba Geigy | Neue Peptide und Verfahren zu ihrer Herstellung |
| GB1294771A (en) * | 1969-01-31 | 1972-11-01 | Sandoz Ltd | Thyrocalcitonin derivative |
| FR2585702B1 (fr) * | 1985-07-31 | 1989-03-03 | Lafon Labor | Derives de phenyl-piperazine, procede de preparation et utilisation en therapeutique |
-
1968
- 1968-05-14 CA CA019947A patent/CA919590A/en not_active Expired
- 1968-05-15 DE DE19681767477 patent/DE1767477C3/de not_active Expired
- 1968-05-17 FR FR1576527D patent/FR1576527A/fr not_active Expired
- 1968-05-20 GB GB2389768A patent/GB1236801A/en not_active Expired
- 1968-05-22 NL NL6807271A patent/NL6807271A/xx unknown
- 1968-05-22 BE BE715572D patent/BE715572A/xx unknown
- 1968-08-13 FR FR162828A patent/FR8477M/fr not_active Expired
-
1974
- 1974-08-31 CY CY75374A patent/CY753A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| NL6807271A (enrdf_load_stackoverflow) | 1968-11-25 |
| BE715572A (enrdf_load_stackoverflow) | 1968-11-22 |
| CY753A (en) | 1974-08-31 |
| DE1767477B2 (de) | 1974-10-24 |
| DE1767477C3 (de) | 1975-06-12 |
| FR1576527A (enrdf_load_stackoverflow) | 1969-08-01 |
| FR8477M (fr) | 1972-06-09 |
| DE1767477A1 (de) | 1971-09-09 |
| CA919590A (en) | 1973-01-23 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PCNP | Patent ceased through non-payment of renewal fee |