GB1197758A - Process for the Preparation of the Tetrasodium Salt of Reduced Nicotinamide-Adenine-Dinucleotide-Phosphate. - Google Patents

Process for the Preparation of the Tetrasodium Salt of Reduced Nicotinamide-Adenine-Dinucleotide-Phosphate.

Info

Publication number
GB1197758A
GB1197758A GB4080667A GB4080667A GB1197758A GB 1197758 A GB1197758 A GB 1197758A GB 4080667 A GB4080667 A GB 4080667A GB 4080667 A GB4080667 A GB 4080667A GB 1197758 A GB1197758 A GB 1197758A
Authority
GB
United Kingdom
Prior art keywords
phosphate
tetrasodium salt
reduced
adenine
dinucleotide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB4080667A
Inventor
Guenter Rose
Hansdieter Nuernberger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AWD Pharma GmbH and Co KG
Original Assignee
Arzneimittelwerk Dresden GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arzneimittelwerk Dresden GmbH filed Critical Arzneimittelwerk Dresden GmbH
Priority to GB4080667A priority Critical patent/GB1197758A/en
Publication of GB1197758A publication Critical patent/GB1197758A/en
Expired legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16Purine radicals
    • C07H19/20Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)

Abstract

1,197,758. Tetrasodium salt of reduced nicotinamide - adenine - dinucleotide phosphate. ARZNEIMITTELWERK DRESDEN VEB. 6 Sept., 1967, No. 40806/67. Heading C2C. The tetrasodium salt of reduced nicotinamideadeninedinucleotide phosphate is prepared by applying a solution of reduced nicotinamideadeninedinucleotide phosphate to a column of DEAE cellulose and eluting with a volatile buffer medium having a pH of less than 8 and having a linear increasing gradient of a sodium halide which is soluble in alcohol, the pH of the eluate being then adjusted to about 10 by adding a dilute aqueous solution of sodium hydroxide. The elution is preferably carried out at about 4‹ C. Good results are obtained by using the system pyridine-acetic acid or ethylene diamine-acetic acid at a pH below 8, e.g. 7À6-7À8, as the volatile buffer and using NaI or NaBr as the sodium halide.
GB4080667A 1967-09-06 1967-09-06 Process for the Preparation of the Tetrasodium Salt of Reduced Nicotinamide-Adenine-Dinucleotide-Phosphate. Expired GB1197758A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
GB4080667A GB1197758A (en) 1967-09-06 1967-09-06 Process for the Preparation of the Tetrasodium Salt of Reduced Nicotinamide-Adenine-Dinucleotide-Phosphate.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB4080667A GB1197758A (en) 1967-09-06 1967-09-06 Process for the Preparation of the Tetrasodium Salt of Reduced Nicotinamide-Adenine-Dinucleotide-Phosphate.

Publications (1)

Publication Number Publication Date
GB1197758A true GB1197758A (en) 1970-07-08

Family

ID=10416710

Family Applications (1)

Application Number Title Priority Date Filing Date
GB4080667A Expired GB1197758A (en) 1967-09-06 1967-09-06 Process for the Preparation of the Tetrasodium Salt of Reduced Nicotinamide-Adenine-Dinucleotide-Phosphate.

Country Status (1)

Country Link
GB (1) GB1197758A (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151349A (en) * 1977-02-01 1979-04-24 Boehringer Mannheim Gmbh Crystalline potassium salt of β-nicotinamide adenine dinucleotide phosphoric acid and method for its preparation
CN112774254A (en) * 2021-01-09 2021-05-11 北京智飞绿竹生物制药有限公司 Method for cleaning ion exchange chromatography medium

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4151349A (en) * 1977-02-01 1979-04-24 Boehringer Mannheim Gmbh Crystalline potassium salt of β-nicotinamide adenine dinucleotide phosphoric acid and method for its preparation
CN112774254A (en) * 2021-01-09 2021-05-11 北京智飞绿竹生物制药有限公司 Method for cleaning ion exchange chromatography medium

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Legal Events

Date Code Title Description
PS Patent sealed
PLNP Patent lapsed through nonpayment of renewal fees