GB1233194A - - Google Patents
Info
- Publication number
- GB1233194A GB1233194A GB1233194DA GB1233194A GB 1233194 A GB1233194 A GB 1233194A GB 1233194D A GB1233194D A GB 1233194DA GB 1233194 A GB1233194 A GB 1233194A
- Authority
- GB
- United Kingdom
- Prior art keywords
- formyl
- morphinan
- derivatives
- ccooh
- aug
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KRKZHDBTLHCVRL-BBWFWOEESA-N (1R,9R,10R)-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2,4,6-triene-17-carbaldehyde Chemical class C1CCC[C@H]2[C@]3([H])N(C=O)CC[C@@]21C1=CC=CC=C1C3 KRKZHDBTLHCVRL-BBWFWOEESA-N 0.000 abstract 2
- AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 abstract 2
- TZIHFWKZFHZASV-UHFFFAOYSA-N methyl formate Chemical compound COC=O TZIHFWKZFHZASV-UHFFFAOYSA-N 0.000 abstract 2
- FZNYYMPPLIJMRC-CGTJXYLNSA-N (1R,9R,10R)-4-methoxy-17-azatetracyclo[7.5.3.01,10.02,7]heptadeca-2(7),3,5-triene-17-carbaldehyde Chemical compound C(=O)N1[C@H]2[C@@H]3CCCC[C@@]3(C=3C=C(C=CC3C2)OC)CC1 FZNYYMPPLIJMRC-CGTJXYLNSA-N 0.000 abstract 1
- NENLYAQPNATJSU-UHFFFAOYSA-N 1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline Chemical class C1NCCC2CCCCC21 NENLYAQPNATJSU-UHFFFAOYSA-N 0.000 abstract 1
- BDAGIHXWWSANSR-UHFFFAOYSA-N Formic acid Chemical compound OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 230000002378 acidificating effect Effects 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 150000005840 aryl radicals Chemical class 0.000 abstract 1
- 125000001589 carboacyl group Chemical group 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 238000006170 formylation reaction Methods 0.000 abstract 1
- 150000002537 isoquinolines Chemical class 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 abstract 1
- INAXVFBXDYWQFN-XHSDSOJGSA-N morphinan Chemical class C1C2=CC=CC=C2[C@]23CCCC[C@H]3[C@@H]1NCC2 INAXVFBXDYWQFN-XHSDSOJGSA-N 0.000 abstract 1
- 229940051807 opiod analgesics morphinan derivative Drugs 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- RLOWWWKZYUNIDI-UHFFFAOYSA-N phosphinic chloride Chemical compound ClP=O RLOWWWKZYUNIDI-UHFFFAOYSA-N 0.000 abstract 1
- 229920000137 polyphosphoric acid Polymers 0.000 abstract 1
- 239000000376 reactant Substances 0.000 abstract 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
- C07D217/18—Aralkyl radicals
- C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
- C07D217/24—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
- C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
- C07D221/22—Bridged ring systems
- C07D221/28—Morphinans
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US66321067A | 1967-08-25 | 1967-08-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1233194A true GB1233194A (enrdf_load_stackoverflow) | 1971-05-26 |
Family
ID=24660890
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1233194D Expired GB1233194A (enrdf_load_stackoverflow) | 1967-08-25 | 1968-08-22 | |
| GB1233193D Expired GB1233193A (enrdf_load_stackoverflow) | 1967-08-25 | 1968-08-22 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB1233193D Expired GB1233193A (enrdf_load_stackoverflow) | 1967-08-25 | 1968-08-22 |
Country Status (8)
| Country | Link |
|---|---|
| BE (1) | BE719788A (enrdf_load_stackoverflow) |
| CH (2) | CH543514A (enrdf_load_stackoverflow) |
| DE (1) | DE1795193C2 (enrdf_load_stackoverflow) |
| DK (1) | DK129238B (enrdf_load_stackoverflow) |
| FR (1) | FR1584396A (enrdf_load_stackoverflow) |
| GB (2) | GB1233194A (enrdf_load_stackoverflow) |
| NL (1) | NL158791B (enrdf_load_stackoverflow) |
| SE (1) | SE364511B (enrdf_load_stackoverflow) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260286A (en) * | 1992-10-16 | 1993-11-09 | Japan Tobacco, Inc. | 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2327737A1 (de) * | 1972-07-07 | 1974-01-24 | Hoffmann La Roche | Verfahren zur herstellung von isomorphinanen |
| US4003903A (en) * | 1975-02-12 | 1977-01-18 | Florida Board Of Regents | N-acyl-N-norsalutaridines and process for making them |
| FI773636A7 (fi) * | 1976-12-06 | 1978-06-07 | Hoffmann La Roche | Nya fenylderivat |
| US4194044A (en) | 1976-12-06 | 1980-03-18 | Hoffmann-La Roche Inc. | Process for preparing 3-phenoxy morphinans |
| US4668685A (en) * | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| CH657007GA3 (enrdf_load_stackoverflow) * | 1984-08-23 | 1986-08-15 | Tissot Sa | |
| CH684619B5 (fr) * | 1992-07-17 | 1995-05-15 | Longines Montres Comp D | Pièce d'horlogerie à affichage universel de l'heure. |
| US5905153A (en) * | 1996-10-02 | 1999-05-18 | Roche Vitamins Inc. | Process for preparing (9α,13α,14α)-1-(3-methoxy-morphinan-17-yl)alkanones |
| EP0834506B1 (de) * | 1996-10-02 | 2004-01-14 | F. Hoffmann-La Roche Ag | Verfahren zur Herstellung von (9alpha, 13alpha, 14alpha)-1-(3-Methoxymorphinan-17-yl)alkanonen |
| EP3712714B1 (fr) | 2019-03-19 | 2022-11-30 | Omega SA | Cadran pour une montre universelle |
-
1968
- 1968-08-02 CH CH1157868A patent/CH543514A/de not_active IP Right Cessation
- 1968-08-02 CH CH231871A patent/CH560194A5/xx not_active IP Right Cessation
- 1968-08-21 FR FR1584396D patent/FR1584396A/fr not_active Expired
- 1968-08-21 DE DE19681795193 patent/DE1795193C2/de not_active Expired
- 1968-08-22 BE BE719788D patent/BE719788A/xx not_active IP Right Cessation
- 1968-08-22 GB GB1233194D patent/GB1233194A/en not_active Expired
- 1968-08-22 DK DK405568A patent/DK129238B/da not_active IP Right Cessation
- 1968-08-22 GB GB1233193D patent/GB1233193A/en not_active Expired
- 1968-08-22 NL NL6811979A patent/NL158791B/xx not_active IP Right Cessation
- 1968-08-23 SE SE1142868A patent/SE364511B/xx unknown
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260286A (en) * | 1992-10-16 | 1993-11-09 | Japan Tobacco, Inc. | 2-piperidinecarboxylic acid derivatives useful as NMDA receptor antagonists |
Also Published As
| Publication number | Publication date |
|---|---|
| CH560194A5 (enrdf_load_stackoverflow) | 1975-03-27 |
| DK129238C (enrdf_load_stackoverflow) | 1975-02-03 |
| SE364511B (enrdf_load_stackoverflow) | 1974-02-25 |
| NL158791B (nl) | 1978-12-15 |
| DK129238B (da) | 1974-09-16 |
| GB1233193A (enrdf_load_stackoverflow) | 1971-05-26 |
| DE1795193A1 (de) | 1971-12-30 |
| FR1584396A (enrdf_load_stackoverflow) | 1969-12-19 |
| DE1795193C2 (de) | 1984-08-23 |
| CH543514A (de) | 1973-10-31 |
| NL6811979A (enrdf_load_stackoverflow) | 1969-02-27 |
| BE719788A (enrdf_load_stackoverflow) | 1969-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed | ||
| PE20 | Patent expired after termination of 20 years |