GB1230498A - - Google Patents
Info
- Publication number
- GB1230498A GB1230498A GB1230498DA GB1230498A GB 1230498 A GB1230498 A GB 1230498A GB 1230498D A GB1230498D A GB 1230498DA GB 1230498 A GB1230498 A GB 1230498A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alkyl
- formula
- denotes
- pyrazolidinols
- disubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
1,230,498. Benzoate esters of 4-pyrazolidinols. A. H. ROBINS CO. Inc. 5 May, 1969 [9 May, 1968], No. 22816/69. Heading C2C. Novel compounds of the formula where the R's are the same and denote C 1-8 alkyl or phenyl-C 1-8 alkyl ; R<SP>1</SP> denotes H, NO 2 , C 1-8 alkyl, C 1-8 alkoxy, F, Cl, Br, NH 2 , -NHC 1-8 alkyl, or CF 3 ; R<SP>2</SP> denotes H, C 1-8 alkoxy, F, Cl or Br; and acid addition salts thereof, are obtained by reaction of a 1,2- disubstituted - 4 - pyrazolidinol of the formula wherein Y denotes halogen or OH. 1,2 - Disubstituted - 4 - pyrazolidinols of Formula (II) are prepared by reacting hydrazines R.NHNHR with epichlorohydrin at temperatures of 0-24 C. Pharmaceutical compositions for use as local anaesthetics comprise compounds of Formula (I) above, or addition salts thereof in the form of sprays, lotions and ointments for topical application. Preparations for infiltration, nerve block, spinal, peridural and caudal anaesthesia comprise aqueous sterile solutions of the salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72806568A | 1968-05-09 | 1968-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1230498A true GB1230498A (en) | 1971-05-05 |
Family
ID=24925266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB1230498D Expired GB1230498A (en) | 1968-05-09 | 1969-05-05 |
Country Status (8)
Country | Link |
---|---|
US (1) | US3542804A (en) |
BR (1) | BR6908548D0 (en) |
CH (1) | CH531517A (en) |
DE (1) | DE1923850A1 (en) |
ES (1) | ES366561A1 (en) |
FR (1) | FR2008146A1 (en) |
GB (1) | GB1230498A (en) |
IL (1) | IL32106A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4207327A (en) * | 1977-08-19 | 1980-06-10 | A. H. Robins Company, Inc. | N-(4-Pyrazolidinyl)benzamides and their amino precursors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2838521A (en) * | 1956-05-17 | 1958-06-10 | Robins Co Inc A H | Esters of amino alcohols |
-
1968
- 1968-05-09 US US728065A patent/US3542804A/en not_active Expired - Lifetime
-
1969
- 1969-04-28 ES ES366561A patent/ES366561A1/en not_active Expired
- 1969-04-29 IL IL32106A patent/IL32106A/en unknown
- 1969-05-05 GB GB1230498D patent/GB1230498A/en not_active Expired
- 1969-05-06 BR BR208548/69A patent/BR6908548D0/en unknown
- 1969-05-08 FR FR6914835A patent/FR2008146A1/fr not_active Withdrawn
- 1969-05-08 CH CH702669A patent/CH531517A/en not_active IP Right Cessation
- 1969-05-09 DE DE19691923850 patent/DE1923850A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
US3542804A (en) | 1970-11-24 |
DE1923850A1 (en) | 1969-11-20 |
BR6908548D0 (en) | 1973-02-08 |
ES366561A1 (en) | 1971-07-01 |
IL32106A (en) | 1972-03-28 |
IL32106A0 (en) | 1969-06-25 |
CH531517A (en) | 1972-12-15 |
FR2008146A1 (en) | 1970-01-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PS | Patent sealed [section 19, patents act 1949] | ||
PLNP | Patent lapsed through nonpayment of renewal fees |