ES366561A1 - Benzoate esters of 4-pyrazolidinols - Google Patents

Benzoate esters of 4-pyrazolidinols

Info

Publication number
ES366561A1
ES366561A1 ES366561A ES366561A ES366561A1 ES 366561 A1 ES366561 A1 ES 366561A1 ES 366561 A ES366561 A ES 366561A ES 366561 A ES366561 A ES 366561A ES 366561 A1 ES366561 A1 ES 366561A1
Authority
ES
Spain
Prior art keywords
alkyl
formula
denotes
pyrazolidinols
disubstituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES366561A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AH Robins Co Inc
Original Assignee
AH Robins Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AH Robins Co Inc filed Critical AH Robins Co Inc
Publication of ES366561A1 publication Critical patent/ES366561A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds of the formula where the R's are the same and denote C 1-8 alkyl or phenyl-C 1-8 alkyl R1 denotes H, NO 2 , C 1-8 alkyl, C 1-8 alkoxy, F, Cl, Br, NH 2 , -NHC 1-8 alkyl, or CF 3 R2 denotes H, C 1-8 alkoxy, F, Cl or Br and acid addition salts thereof, are obtained by reaction of a 1,2- disubstituted - 4 - pyrazolidinol of the formula wherein Y denotes halogen or OH. 1,2 - Disubstituted - 4 - pyrazolidinols of Formula (II) are prepared by reacting hydrazines R.NHNHR with epichlorohydrin at temperatures of 0-24 C. Pharmaceutical compositions for use as local anaesthetics comprise compounds of Formula (I) above, or addition salts thereof in the form of sprays, lotions and ointments for topical application. Preparations for infiltration, nerve block, spinal, peridural and caudal anaesthesia comprise aqueous sterile solutions of the salts.
ES366561A 1968-05-09 1969-04-28 Benzoate esters of 4-pyrazolidinols Expired ES366561A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72806568A 1968-05-09 1968-05-09

Publications (1)

Publication Number Publication Date
ES366561A1 true ES366561A1 (en) 1971-07-01

Family

ID=24925266

Family Applications (1)

Application Number Title Priority Date Filing Date
ES366561A Expired ES366561A1 (en) 1968-05-09 1969-04-28 Benzoate esters of 4-pyrazolidinols

Country Status (8)

Country Link
US (1) US3542804A (en)
BR (1) BR6908548D0 (en)
CH (1) CH531517A (en)
DE (1) DE1923850A1 (en)
ES (1) ES366561A1 (en)
FR (1) FR2008146A1 (en)
GB (1) GB1230498A (en)
IL (1) IL32106A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4207327A (en) * 1977-08-19 1980-06-10 A. H. Robins Company, Inc. N-(4-Pyrazolidinyl)benzamides and their amino precursors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2838521A (en) * 1956-05-17 1958-06-10 Robins Co Inc A H Esters of amino alcohols

Also Published As

Publication number Publication date
FR2008146A1 (en) 1970-01-16
GB1230498A (en) 1971-05-05
IL32106A0 (en) 1969-06-25
DE1923850A1 (en) 1969-11-20
US3542804A (en) 1970-11-24
CH531517A (en) 1972-12-15
IL32106A (en) 1972-03-28
BR6908548D0 (en) 1973-02-08

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