ES366561A1 - Benzoate esters of 4-pyrazolidinols - Google Patents
Benzoate esters of 4-pyrazolidinolsInfo
- Publication number
- ES366561A1 ES366561A1 ES366561A ES366561A ES366561A1 ES 366561 A1 ES366561 A1 ES 366561A1 ES 366561 A ES366561 A ES 366561A ES 366561 A ES366561 A ES 366561A ES 366561 A1 ES366561 A1 ES 366561A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- formula
- denotes
- pyrazolidinols
- disubstituted
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/04—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel compounds of the formula where the R's are the same and denote C 1-8 alkyl or phenyl-C 1-8 alkyl R1 denotes H, NO 2 , C 1-8 alkyl, C 1-8 alkoxy, F, Cl, Br, NH 2 , -NHC 1-8 alkyl, or CF 3 R2 denotes H, C 1-8 alkoxy, F, Cl or Br and acid addition salts thereof, are obtained by reaction of a 1,2- disubstituted - 4 - pyrazolidinol of the formula wherein Y denotes halogen or OH. 1,2 - Disubstituted - 4 - pyrazolidinols of Formula (II) are prepared by reacting hydrazines R.NHNHR with epichlorohydrin at temperatures of 0-24 C. Pharmaceutical compositions for use as local anaesthetics comprise compounds of Formula (I) above, or addition salts thereof in the form of sprays, lotions and ointments for topical application. Preparations for infiltration, nerve block, spinal, peridural and caudal anaesthesia comprise aqueous sterile solutions of the salts.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US72806568A | 1968-05-09 | 1968-05-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES366561A1 true ES366561A1 (en) | 1971-07-01 |
Family
ID=24925266
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES366561A Expired ES366561A1 (en) | 1968-05-09 | 1969-04-28 | Benzoate esters of 4-pyrazolidinols |
Country Status (8)
Country | Link |
---|---|
US (1) | US3542804A (en) |
BR (1) | BR6908548D0 (en) |
CH (1) | CH531517A (en) |
DE (1) | DE1923850A1 (en) |
ES (1) | ES366561A1 (en) |
FR (1) | FR2008146A1 (en) |
GB (1) | GB1230498A (en) |
IL (1) | IL32106A (en) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4207327A (en) * | 1977-08-19 | 1980-06-10 | A. H. Robins Company, Inc. | N-(4-Pyrazolidinyl)benzamides and their amino precursors |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2838521A (en) * | 1956-05-17 | 1958-06-10 | Robins Co Inc A H | Esters of amino alcohols |
-
1968
- 1968-05-09 US US728065A patent/US3542804A/en not_active Expired - Lifetime
-
1969
- 1969-04-28 ES ES366561A patent/ES366561A1/en not_active Expired
- 1969-04-29 IL IL32106A patent/IL32106A/en unknown
- 1969-05-05 GB GB1230498D patent/GB1230498A/en not_active Expired
- 1969-05-06 BR BR208548/69A patent/BR6908548D0/en unknown
- 1969-05-08 FR FR6914835A patent/FR2008146A1/fr not_active Withdrawn
- 1969-05-08 CH CH702669A patent/CH531517A/en not_active IP Right Cessation
- 1969-05-09 DE DE19691923850 patent/DE1923850A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
GB1230498A (en) | 1971-05-05 |
DE1923850A1 (en) | 1969-11-20 |
IL32106A (en) | 1972-03-28 |
US3542804A (en) | 1970-11-24 |
FR2008146A1 (en) | 1970-01-16 |
BR6908548D0 (en) | 1973-02-08 |
CH531517A (en) | 1972-12-15 |
IL32106A0 (en) | 1969-06-25 |
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