GB1216141A - Peptides having acth-activity - Google Patents
Peptides having acth-activityInfo
- Publication number
- GB1216141A GB1216141A GB2058/68A GB205868A GB1216141A GB 1216141 A GB1216141 A GB 1216141A GB 2058/68 A GB2058/68 A GB 2058/68A GB 205868 A GB205868 A GB 205868A GB 1216141 A GB1216141 A GB 1216141A
- Authority
- GB
- United Kingdom
- Prior art keywords
- boc
- lys
- val
- pro
- tyr
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 6
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 5
- 108010053725 prolylvaline Proteins 0.000 abstract 3
- 150000001875 compounds Chemical class 0.000 abstract 2
- 108010015792 glycyllysine Proteins 0.000 abstract 2
- CNBUSIJNWNXLQQ-NSHDSACASA-N (2s)-3-(4-hydroxyphenyl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)N[C@H](C(O)=O)CC1=CC=C(O)C=C1 CNBUSIJNWNXLQQ-NSHDSACASA-N 0.000 abstract 1
- FHOAKXBXYSJBGX-YFKPBYRVSA-N (2s)-3-hydroxy-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoic acid Chemical compound CC(C)(C)OC(=O)N[C@@H](CO)C(O)=O FHOAKXBXYSJBGX-YFKPBYRVSA-N 0.000 abstract 1
- 108010092526 GKPV peptide Proteins 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 150000001413 amino acids Chemical class 0.000 abstract 1
- LHHCSNFAOIFYRV-DOVBMPENSA-N boceprevir Chemical class O=C([C@@H]1[C@@H]2[C@@H](C2(C)C)CN1C(=O)[C@@H](NC(=O)NC(C)(C)C)C(C)(C)C)NC(C(=O)C(N)=O)CC1CCC1 LHHCSNFAOIFYRV-DOVBMPENSA-N 0.000 abstract 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 abstract 1
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000007911 parenteral administration Methods 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 108010020532 tyrosyl-proline Proteins 0.000 abstract 1
- 108010073969 valyllysine Proteins 0.000 abstract 1
- 108010009962 valyltyrosine Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/695—Corticotropin [ACTH]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
1,216,141. A.C.T.H.-active-peptides. CIBA Ltd. 15 Jan., 1968 [17 Jan., 1967; 23 June, 1967], No. 2058/68. Addition to 1,119,353. Heading C2C. Novel peptides H-D-ser-tyr-ser-nle-glu-hisphe - arg - try - gly - lys - pro - val - gly - lyslys - lys - lys - pro - val lys - val - tyr - pro- (OH or NH 2 ) and the corresponding compounds containing the glutamine residue instead of the glutamyl residue and their acid addition salts, functional derivatives and complexes are prepared by methods known per se in the peptide art. Intermediate peptides and amino acids isolated are H - Nle - OCH 3 , BOC - Ser - Nle - OCH 3 , H - Ser - Nle - OCH 3 , BOC - Tyr - Ser - Nle- OCH 3 , H - Tyr - Ser - Nle - OCH 3 , BOC - DSer - Tyr - Ser - Nle - OCH3, BOC - D - Ser- Tyr - Ser - Nle - NH - NH 2 , BOC - D - Ser - Tyr- Ser - Nle - Glu(OtBu) - His - Phe - Arg - Try- Gly - OH, H - Lys(BOC) - Pro - Val - Gly- Lys(BOC) - Lys(BOC) - Lys(BOC) - Lys(BOC)- Pro - Val - Lys(BOC) - Val - Tyr - Pro - OtBu, Z - Val - Tyr - Pro - NH 2 , H - Val - Tyr - Pro- NH 2 , Z - Lys(BOC) - Val - Tyr - Pro - NH 2 , HLys(BOC) - Val - Tyr - Pro - NH 2 , Z - Val- Lys(BOC) - Val - Tyr - Pro - NH 2 , Z - Lys (BOC) - Lys(BOC) - Pro - Val - Lys(BOC) - Val- Tyr - Pro - NH 2 , Z - Lys(BOC) - Pro - Val - Gly- Lys(BOC) - Lys(BOC) - Lys(BOC) - Lys(BOC)- Pro - Val - Lys(BOC) - Val - Tyr - Pro - NH 2 and the N-unprotected peptides corresponding to the previous three protected peptides. Pharmaceutical compositions comprise one of the novel compounds in admixture with a suitable excipient for enteral or parenteral administration.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH66767 | 1967-01-17 | ||
| CH895367 | 1967-06-23 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1216141A true GB1216141A (en) | 1970-12-16 |
Family
ID=25685305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB2058/68A Expired GB1216141A (en) | 1967-01-17 | 1968-01-15 | Peptides having acth-activity |
Country Status (7)
| Country | Link |
|---|---|
| JP (1) | JPS4825186B1 (en) |
| BE (1) | BE709454A (en) |
| CH (1) | CH540229A (en) |
| DE (1) | DE1668875A1 (en) |
| FR (1) | FR7330M (en) |
| GB (1) | GB1216141A (en) |
| NL (1) | NL6800661A (en) |
-
1967
- 1967-01-17 CH CH66767A patent/CH540229A/en not_active IP Right Cessation
-
1968
- 1968-01-09 DE DE19681668875 patent/DE1668875A1/en active Pending
- 1968-01-15 GB GB2058/68A patent/GB1216141A/en not_active Expired
- 1968-01-16 BE BE709454D patent/BE709454A/xx unknown
- 1968-01-16 NL NL6800661A patent/NL6800661A/xx unknown
- 1968-01-17 JP JP43002203A patent/JPS4825186B1/ja active Pending
- 1968-03-26 FR FR145374A patent/FR7330M/fr not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE1668875A1 (en) | 1971-07-29 |
| NL6800661A (en) | 1968-07-18 |
| CH540229A (en) | 1973-09-28 |
| JPS4825186B1 (en) | 1973-07-26 |
| BE709454A (en) | 1968-07-16 |
| FR7330M (en) | 1969-10-06 |
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