GB1357121A - Peptide enzyme inhibitors - Google Patents

Peptide enzyme inhibitors

Info

Publication number
GB1357121A
GB1357121A GB1104871A GB1104871A GB1357121A GB 1357121 A GB1357121 A GB 1357121A GB 1104871 A GB1104871 A GB 1104871A GB 1104871 A GB1104871 A GB 1104871A GB 1357121 A GB1357121 A GB 1357121A
Authority
GB
United Kingdom
Prior art keywords
asn
peptides
pro
iii
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB1104871A
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
ER Squibb and Sons LLC
Original Assignee
ER Squibb and Sons LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ER Squibb and Sons LLC filed Critical ER Squibb and Sons LLC
Publication of GB1357121A publication Critical patent/GB1357121A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04—Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06156—Dipeptides with the first amino acid being heterocyclic and Trp-amino acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0821—Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1357121 Peptides E R SQUIBB & SONS Inc 23 April 1971 [28 July 1970] 11048/71 Heading C2C Peptides of the formulae (I), (II) and (III) (where X is Asn, Ser or Nle, n is 0 or 1, Y is Arg, His, Lys or Gly and Z is Asn or Gln) or their derivatives in which at least one carboxyl, amino, guanidino or hydroxy group is protected or a salt thereof are prepared by standard procedures especially by condensing the residue Trp-Pro-Y-Pro with remaining residues or amino acids using a solid phase process. The compounds (I)-(III) inhibit the conversion of angiotenisn (I) to angiotensin (II) and are thus hypotensive agents. The compounds are also biodegradable UV absorbents. Pharmaceutical compositions are in forms for oral and parenteral administration.
GB1104871A 1970-07-28 1971-04-23 Peptide enzyme inhibitors Expired GB1357121A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US5868670A 1970-07-28 1970-07-28

Publications (1)

Publication Number Publication Date
GB1357121A true GB1357121A (en) 1974-06-19

Family

ID=22018295

Family Applications (2)

Application Number Title Priority Date Filing Date
GB1104871A Expired GB1357121A (en) 1970-07-28 1971-04-23 Peptide enzyme inhibitors
GB2179473A Expired GB1357122A (en) 1970-07-28 1971-04-23 Polypeptide intermediates

Family Applications After (1)

Application Number Title Priority Date Filing Date
GB2179473A Expired GB1357122A (en) 1970-07-28 1971-04-23 Polypeptide intermediates

Country Status (9)

Country Link
JP (1) JPS546556B1 (en)
CA (1) CA946837A (en)
CH (1) CH543483A (en)
DE (1) DE2124451C3 (en)
FR (1) FR2100959B1 (en)
GB (2) GB1357121A (en)
HU (1) HU164325B (en)
IE (1) IE35074B1 (en)
NL (1) NL165655C (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0979829A2 (en) * 1998-08-13 2000-02-16 Beiersdorf Aktiengesellschaft Cosmetic or dermatologic compositions containing oligopeptides for clearing age spots, e.g. for prevention of skin tanning, in particular when caused by UV-radiations
WO2006105805A1 (en) * 2005-04-07 2006-10-12 Miso Sabovic Delaying skin ageing and disorders caused by skin ageing by suppression of angiotensin ii production or activity
WO2009058244A1 (en) * 2007-10-29 2009-05-07 Helix Biomedix Inc. Protective skin care tetrapeptides

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4108886A (en) * 1977-03-11 1978-08-22 E. R. Squibb & Sons, Inc. Thiopropanoylamino acid derivatives

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0979829A2 (en) * 1998-08-13 2000-02-16 Beiersdorf Aktiengesellschaft Cosmetic or dermatologic compositions containing oligopeptides for clearing age spots, e.g. for prevention of skin tanning, in particular when caused by UV-radiations
EP0979829A3 (en) * 1998-08-13 2000-03-01 Beiersdorf Aktiengesellschaft Cosmetic or dermatologic compositions containing oligopeptides for clearing age spots, e.g. for prevention of skin tanning, in particular when caused by UV-radiations
US6852699B1 (en) 1998-08-13 2005-02-08 Beiersdorf Ag Cosmetic or dermatological preparations comprising oligopeptides for lightening the skin of age marks and/or for preventing tanning of the skin, in particular tanning of the skin caused by uv radiation
US7498310B1 (en) 1998-08-13 2009-03-03 Beiersdorf Ag Cosmetic or dermatological preparations comprising oligopeptides for lightening the skin of age marks and/or for preventing tanning of the skin, in particular tanning of the skin caused by UV radiation
WO2006105805A1 (en) * 2005-04-07 2006-10-12 Miso Sabovic Delaying skin ageing and disorders caused by skin ageing by suppression of angiotensin ii production or activity
WO2009058244A1 (en) * 2007-10-29 2009-05-07 Helix Biomedix Inc. Protective skin care tetrapeptides
US8071555B2 (en) 2007-10-29 2011-12-06 Helix Biomedix Inc. Protective skin care peptides
CN101855235B (en) * 2007-10-29 2013-04-24 赫里克斯生物医疗公司 Protective skin care tetrapeptides

Also Published As

Publication number Publication date
HU164325B (en) 1974-01-28
JPS546556B1 (en) 1979-03-29
NL7108452A (en) 1972-02-01
IE35074L (en) 1972-01-28
GB1357122A (en) 1974-06-19
FR2100959B1 (en) 1974-09-06
NL165655B (en) 1980-12-15
CA946837A (en) 1974-05-07
CH543483A (en) 1973-10-31
DE2124451A1 (en) 1972-02-24
DE2124451B2 (en) 1979-11-29
NL165655C (en) 1981-05-15
IE35074B1 (en) 1975-10-29
DE2124451C3 (en) 1980-09-18
FR2100959A1 (en) 1972-03-24

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Legal Events

Date Code Title Description
PS Patent sealed
PE20 Patent expired after termination of 20 years