GB1231494A - - Google Patents

Info

Publication number
GB1231494A
GB1231494A GB1231494DA GB1231494A GB 1231494 A GB1231494 A GB 1231494A GB 1231494D A GB1231494D A GB 1231494DA GB 1231494 A GB1231494 A GB 1231494A
Authority
GB
United Kingdom
Prior art keywords
lys
boc
val
gly
cbo
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH1058364A external-priority patent/CH499497A/en
Application filed filed Critical
Publication of GB1231494A publication Critical patent/GB1231494A/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
    • C07K14/695—Corticotropin [ACTH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06086—Dipeptides with the first amino acid being basic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Abstract

1,231,494. ACTH-active peptides. CIBAGEIGY A.G. 9 July, 1968 [12 July, 1967], No. 32616/68. Addition to 1,119,353. Heading C2C. Novel peptides H-D-ser-tyr-ser-met-glu-hisphe - arg - try - gly - lys - pro - val - gly - lyslys - lys - lys - val - NH 2 and H - D - ser - tyrser - nle - glu - his - phe - arg - try - gly - lyspro - val - gly - lys - lys - lys - lys - val - NH 2 and their therapeutically acceptable acid addition salts and complexes are prepared by standard methods of peptide synthesis. The following compounds are isolated as intermediates: N<SP>α</SP> - CBO - lys(BOC) - val- NH 2 ; H - lys(BOC) - val - NH 2 ; CBO - lys(BOC) lys(BOC) - val - NH 2 ; H - lys(BOC) - lys(BOC)- val - NH 2 ; CBO - lys(BOC) - pro - val - glylys(BOC) - lys(BOC) - lys(BOC) - lys(BOC)- val - NH 2 ; H - lys(BOC) - pro - val - gly - lys- (BOC) - lys(BOC) - lys(BOC) - lys(BOC) - val- NH 2 ; and the novel peptides in which the terminal and side chain NH 2 groups and the side chain -COOH group of the glutamic acid residue are protected. Pharmaceutical compositions comprise the peptides of the invention in admixture with a suitable carrier and are formulated for enteral or parenteral administration.
GB1231494D 1964-08-13 1968-07-09 Expired GB1231494A (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CH1058364A CH499497A (en) 1964-08-13 1964-08-13 ACTH active peptides
CH1550964 1964-12-02
CH303765A CH548986A (en) 1964-08-13 1965-03-04 PROCESS FOR PRODUCING NEW PEPTIDES WITH ACTH EFFECT.
CH831665 1965-06-15
CH995167 1967-07-12

Publications (1)

Publication Number Publication Date
GB1231494A true GB1231494A (en) 1971-05-12

Family

ID=4357464

Family Applications (1)

Application Number Title Priority Date Filing Date
GB1231494D Expired GB1231494A (en) 1964-08-13 1968-07-09

Country Status (8)

Country Link
JP (1) JPS4825187B1 (en)
AT (1) AT309702B (en)
DE (1) DE1768814A1 (en)
DK (1) DK128416B (en)
FR (2) FR95422E (en)
GB (1) GB1231494A (en)
NL (1) NL6809836A (en)
SE (1) SE359823B (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9913905B2 (en) 2013-09-11 2018-03-13 Eagle Biologics, Inc. Liquid pharmaceutical formulations for injection comprising thiamine pyrophosphate 1-(3-aminopropyl)-2-methyl-1H-imidazole and uses thereof
US11471479B2 (en) 2014-10-01 2022-10-18 Eagle Biologics, Inc. Polysaccharide and nucleic acid formulations containing viscosity-lowering agents

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9913905B2 (en) 2013-09-11 2018-03-13 Eagle Biologics, Inc. Liquid pharmaceutical formulations for injection comprising thiamine pyrophosphate 1-(3-aminopropyl)-2-methyl-1H-imidazole and uses thereof
US9925263B2 (en) 2013-09-11 2018-03-27 Eagle Biologics, Inc. Liquid pharmaceutical formulations for injection comprising procaine and uses thereof
US10179172B2 (en) 2013-09-11 2019-01-15 Eagle Biologics, Inc. Liquid pharmaceutical formulations for injection comprising yellow 5 or orange G and uses thereof
US10646571B2 (en) 2013-09-11 2020-05-12 Eagle Biologics, Inc. Liquid protein formulations containing cimetidine
US10821184B2 (en) 2013-09-11 2020-11-03 Eagle Biologics, Inc. Liquid protein formulations containing thiamine pyrophosphate (TPP)
US10821183B2 (en) 2013-09-11 2020-11-03 Eagle Biologics, Inc. Liquid protein formulations containing 4-(3-butyl-1-imidazolio)-1-butane sulfonate (BIM)
US10849977B2 (en) 2013-09-11 2020-12-01 Eagle Biologics, Inc. Liquid Protein Formulations Containing Thiamine
US11819550B2 (en) 2013-09-11 2023-11-21 Eagle Biologics, Inc. Liquid protein formulations containing cyclic adenosine monophosphate (cAMP) or adenosine triphosphate (ATP)
US11471479B2 (en) 2014-10-01 2022-10-18 Eagle Biologics, Inc. Polysaccharide and nucleic acid formulations containing viscosity-lowering agents

Also Published As

Publication number Publication date
FR95422E (en) 1970-11-06
FR8145M (en) 1970-08-17
NL6809836A (en) 1969-01-14
JPS4825187B1 (en) 1973-07-26
DE1768814A1 (en) 1972-01-27
SE359823B (en) 1973-09-10
AT309702B (en) 1973-08-27
DK128416B (en) 1974-04-29

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Legal Events

Date Code Title Description
PS Patent sealed
PCNP Patent ceased through non-payment of renewal fee