ES418929A1 - Procedure for the preparation of polipeptides. (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for the preparation of polipeptides. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES418929A1 ES418929A1 ES418929A ES418929A ES418929A1 ES 418929 A1 ES418929 A1 ES 418929A1 ES 418929 A ES418929 A ES 418929A ES 418929 A ES418929 A ES 418929A ES 418929 A1 ES418929 A1 ES 418929A1
- Authority
- ES
- Spain
- Prior art keywords
- protecting group
- hydrogen atom
- radical
- amino acids
- peptide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/16—Oxytocins; Vasopressins; Related peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Life Sciences & Earth Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Procedure for the preparation of polypeptides of the general formula **(See formula)** in which X represents the radical of an amino acid or a linear peptide of 2 to 6 amino acids and Q represents the radical of arginine or lysine, and where all amino acids with asymmetric center have L configuration, and of its non-toxic and pharmaceutically acceptable acid addition salts, characterized by: a) dissociate from a peptide of the general formula **(See formula)** in which R2 represents the optionally protected radical of an amino acid or a linear peptide of 2 to 6 amino acids; R2 represents a hydrogen atom or an amide protecting group, and Q'represents a grouping of the formula -RH-CH [- (CH2) 3 -NH-C (= NH) -NHR3] -CO- or -NH-CH [- (CH2) 4-NH-R4] -CO-, where R3 represents a hydrogen atom or a guanidine radical protecting group and R4 represents a hydrogen atom or an amine group protecting the lysine radical, provided that at least one of the radicals R1, R2 and R3 or R4 represents or contains a protecting group and wherein all amino acids with asymmetric center have L configuration, the protecting group or groups and optionally converting the free peptide obtained by reaction with an organic or inorganic acid, into a pharmaceutically acceptable and non-toxic acid addition salt; O well b) oxidizing a peptide of the general formula **(See formula)** in which X and Q have the same meaning as before, and R5 and R6 represent in each case a hydrogen atom or a sulfohydryl protecting group, and where all amino acids with an asymmetric center have an L configuration, with simultaneous or preliminary dissociation of the possibly existing protecting groups, and, if desired, converting the product obtained, by reaction with an organic or inorganic acid, into a pharmaceutically acceptable and non-toxic acid addition salt; O well c) oxidizing a peptide of the general formula **(See formula)** in which R1 represents the radical, possibly protected, of an amino acid or a linear peptide of 2 to 6 amino acids; R2 represents a hydrogen atom or an amide protecting group; Q'represents a grouping of the formula -NH-CH [- (CH2) 3-NH-C (= NH) -NHR3] -CO- or -NH- CH [- (CH2) 4-NH-R4] -CO-, where R3 represents a hydrogen atom or a guanidine radical protecting group, and R4 represents a hydrogen atom or an amino group protecting from the lysine radical, and R5 and R6 represent, in each case, a hydrogen atom or a sulfohydryl protecting group, provided that one, at least of the radicals R1, R2 and R3 or R4 represents or contains a protecting group, and wherein all amino acids with asymmetric center have L configuration, with simultaneous dissociation of the protecting group or groups and, if desired, converting the obtained product, by reaction with an organic or inorganic acid into a non-toxic and pharmaceutically acceptable acid addition salt. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH1380372 | 1972-09-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES418929A1 true ES418929A1 (en) | 1976-03-01 |
Family
ID=4395476
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES418929A Expired ES418929A1 (en) | 1972-09-21 | 1973-09-20 | Procedure for the preparation of polipeptides. (Machine-translation by Google Translate, not legally binding) |
Country Status (8)
| Country | Link |
|---|---|
| JP (1) | JPS4969693A (en) |
| AU (1) | AU5966773A (en) |
| BE (1) | BE805132A (en) |
| DE (1) | DE2347456A1 (en) |
| ES (1) | ES418929A1 (en) |
| FR (1) | FR2200001A1 (en) |
| NL (1) | NL7312987A (en) |
| ZA (1) | ZA735680B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0014815A3 (en) * | 1978-12-20 | 1980-10-29 | Ciba-Geigy Ag | Peptide derivatives, process for their preparation and intermediates, and pharmaceutical compositions containing one of these compounds |
| IT1186733B (en) * | 1985-06-05 | 1987-12-16 | Eniricerche Spa | TRIPEPTIDIC COMPOUNDS WITH HYPOTHENSIVE ACTION |
-
1973
- 1973-08-20 ZA ZA735680A patent/ZA735680B/en unknown
- 1973-08-27 AU AU59667/73A patent/AU5966773A/en not_active Expired
- 1973-09-19 JP JP48105082A patent/JPS4969693A/ja active Pending
- 1973-09-20 DE DE19732347456 patent/DE2347456A1/en active Pending
- 1973-09-20 NL NL7312987A patent/NL7312987A/xx unknown
- 1973-09-20 ES ES418929A patent/ES418929A1/en not_active Expired
- 1973-09-21 FR FR7333919A patent/FR2200001A1/en not_active Withdrawn
- 1973-09-21 BE BE135880A patent/BE805132A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2200001A1 (en) | 1974-04-19 |
| ZA735680B (en) | 1974-07-31 |
| JPS4969693A (en) | 1974-07-05 |
| BE805132A (en) | 1974-03-21 |
| NL7312987A (en) | 1974-03-25 |
| DE2347456A1 (en) | 1974-04-11 |
| AU5966773A (en) | 1975-02-27 |
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