ES2104688T3 - A PROCEDURE FOR THE PREPARATION OF A TIO-3-CEFEM 3-SUBSTITUTED COMPOUND. - Google Patents

A PROCEDURE FOR THE PREPARATION OF A TIO-3-CEFEM 3-SUBSTITUTED COMPOUND.

Info

Publication number
ES2104688T3
ES2104688T3 ES91900053T ES91900053T ES2104688T3 ES 2104688 T3 ES2104688 T3 ES 2104688T3 ES 91900053 T ES91900053 T ES 91900053T ES 91900053 T ES91900053 T ES 91900053T ES 2104688 T3 ES2104688 T3 ES 2104688T3
Authority
ES
Spain
Prior art keywords
cefem
tio
procedure
preparation
substituted compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91900053T
Other languages
Spanish (es)
Inventor
Yuichi Yamamoto
Tsuneo Okonogi
Seiji Shibahara
Shigeharu Inoue
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Meiji Seika Kaisha Ltd
Original Assignee
Meiji Seika Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Meiji Seika Kaisha Ltd filed Critical Meiji Seika Kaisha Ltd
Application granted granted Critical
Publication of ES2104688T3 publication Critical patent/ES2104688T3/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

SE PUEDE PRODUCIR UN ESTER DE 7 UIDO 5)$0 PREFERENCIAL, FACIL Y EFICAZMENTE HACIENDO REACCIONAR EL ESTER DE 7 ARBOXILICO CON LA FORMULA GENERAL *FIG* (EN DONDE R1 REPRESENTA ACILO, R REPRESENTA UN GRUPO PROTECTOR DEL GRUPO CARBOXILO Y R'' REPRESENTA ALQUILO INFERIOR O ARILO (NO)SUSTITUIDO) O UNA MEZCLA DE LOS MISMOS CON AMINOS SECUNDARIOS Y TERCIARIOS Y, ADEMAS, REACCIONANDO UNA SAL DE AMINO TERCIARIA DEL PRODUCTO DE REACCION CON UN COMPUESTO DE FORMULA GENERAL (4): R4 QUILO O METILO DE HETEROALQUILO SUSTITUIDO Y X REPRESENTA UN GRUPO DE SALIDA.YOU CAN PRODUCE AN ESTER OF 7 UIDO 5) $ 0 PREFERENTIALLY, EASILY AND EFFECTIVELY BY REACTING THE ESTER OF 7 ARBOXILICO WITH THE GENERAL FORMULA * FIG * (WHERE R1 REPRESENTS ACILO, R REPRESENTS A PROTECTIVE GROUP OF THE CARBOXYLUM GROUP AND LOWER RENT OR ARYL (NOT) REPLACED) OR A MIXTURE OF THE SAME WITH SECONDARY AND TERTIARY AMINES AND, IN ADDITION, REACTING A TERTIARY AMINO SALT OF THE REACTION PRODUCT WITH A COMPOUND OF GENERAL FORMULA (4): R4 QUILO OR METHYL OF METHYL SUBSTITUTED AND X REPRESENTS A DEPARTURE GROUP.

ES91900053T 1989-12-07 1990-12-07 A PROCEDURE FOR THE PREPARATION OF A TIO-3-CEFEM 3-SUBSTITUTED COMPOUND. Expired - Lifetime ES2104688T3 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP1316424A JPH0686459B2 (en) 1989-12-07 1989-12-07 Process for producing 3-substituted thio-3-cephem compound

Publications (1)

Publication Number Publication Date
ES2104688T3 true ES2104688T3 (en) 1997-10-16

Family

ID=18076928

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91900053T Expired - Lifetime ES2104688T3 (en) 1989-12-07 1990-12-07 A PROCEDURE FOR THE PREPARATION OF A TIO-3-CEFEM 3-SUBSTITUTED COMPOUND.

Country Status (6)

Country Link
US (1) US5294705A (en)
EP (1) EP0504404B1 (en)
JP (1) JPH0686459B2 (en)
DE (1) DE69031222T2 (en)
ES (1) ES2104688T3 (en)
WO (1) WO1991009037A1 (en)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL100576A (en) * 1991-01-18 1995-11-27 Eli Lilley And Company Cephalosporin antibiotics
TW427993B (en) * 1993-09-09 2001-04-01 Fujisawa Pharmaceutical Co New cephem compounds
US5698547A (en) * 1994-04-01 1997-12-16 Microcide Pharmaceuticals, Inc. Cephalosporin antibiotics
CZ287296A3 (en) * 1994-04-01 1997-05-14 Microcide Pharmaceuticals Cephalosporin antibiotics and antibacterial preparations in which they are comprised
US5688786A (en) * 1994-04-01 1997-11-18 Microcide Pharmaceuticals, Inc. β-lactam antibiotics
US5498777A (en) * 1994-07-20 1996-03-12 Merck & Co., Inc. 3-thioheteroaryl cephalosporin compounds, compositions and methods of use
AU4123396A (en) * 1994-12-09 1996-06-26 Fujisawa Pharmaceutical Co., Ltd. Cephem compounds and pharmaceutical use thereof
WO2003042219A1 (en) * 2001-11-12 2003-05-22 Hans Rudolf Pfaendler Novel c-3 s/o- and s/n formaldehe acetal derivatives of cephalo sporins and their use as antibiotics

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH605997A5 (en) * 1974-08-30 1978-10-13 Ciba Geigy Ag
US3992377A (en) * 1974-12-13 1976-11-16 Eli Lilly And Company 3-Thio-substituted cephalosporin antibiotics
US4812562A (en) * 1985-07-25 1989-03-14 Taisho Pharmaceutical Co., Ltd. Cephalosporin derivatives
JPS62267228A (en) * 1986-05-16 1987-11-19 Kyowa Hakko Kogyo Co Ltd Antibacterial agent
DE3642450A1 (en) * 1986-12-12 1988-06-23 Bayer Ag SUBSTITUTED BENZAMIDES
JPH01128986A (en) * 1987-11-14 1989-05-22 Banyu Pharmaceut Co Ltd 3-pyridinioalkylthiocephalosporin derivative

Also Published As

Publication number Publication date
EP0504404A1 (en) 1992-09-23
DE69031222D1 (en) 1997-09-11
JPH0686459B2 (en) 1994-11-02
EP0504404A4 (en) 1993-03-10
EP0504404B1 (en) 1997-08-06
DE69031222T2 (en) 1997-12-11
JPH03178980A (en) 1991-08-02
WO1991009037A1 (en) 1991-06-27
US5294705A (en) 1994-03-15

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