GB1212628A - Preparation of salicylanilides derivatives - Google Patents

Preparation of salicylanilides derivatives

Info

Publication number
GB1212628A
GB1212628A GB55818/68A GB5581868A GB1212628A GB 1212628 A GB1212628 A GB 1212628A GB 55818/68 A GB55818/68 A GB 55818/68A GB 5581868 A GB5581868 A GB 5581868A GB 1212628 A GB1212628 A GB 1212628A
Authority
GB
United Kingdom
Prior art keywords
derivatives
halogenated
ring
salicylanilide
reacting
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB55818/68A
Inventor
Earl Martin Chamberlin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of GB1212628A publication Critical patent/GB1212628A/en
Expired legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/16Amides, e.g. hydroxamic acids
    • A61K31/165Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00Carboxylic acid amides
    • C07C233/01Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • EFIXED CONSTRUCTIONS
    • E04BUILDING
    • E04CSTRUCTURAL ELEMENTS; BUILDING MATERIALS
    • E04C5/00Reinforcing elements, e.g. for concrete; Auxiliary elements therefor
    • E04C5/16Auxiliary parts for reinforcements, e.g. connectors, spacers, stirrups
    • E04C5/18Spacers of metal or substantially of metal

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Architecture (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Civil Engineering (AREA)
  • Structural Engineering (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1,212,628. Salicylanilide derivatives. MERCK & CO. Inc. 25 Nov., 1968 [1 Dec., 1967], No. 55818/68. Heading C2C. Salicylanilide derivatives of the formula wherein each of n and n<SP>1</SP> is 0, 1, 2 or 3, each of X and X<SP>1</SP> is halogen, C 1-5 alkyl, halogenated C 1-5 alkyl, NO 2 , CN, halogenated C 1-5 alkoxy or halogenated C 1-5 alkylthio, Q is 0 or 5; Y is H or OH, and Z is Cl, Br or I, and in which Ring C is linked to ring B at the 3<SP>1</SP> or 4<SP>1</SP> position of ring B are prepared by reacting salicylanilide derivatives of the above formula in which 2 is H with bromine, chlorine, iodine, iodine chloride or iodine bromide. 31 - Chloro - 4<SP>1</SP>- (p - chlorophenoxy) - salicylanilide is obtained by reacting salicylic acid with 4 - amino - 2 - chlorophenyl - p - chlorophenyl ether, resulting from the reduction of 2 - chloro - 4 - nitro - phenyl - p - chlorophenylether, which is prepared by reacting 3,4-dichloronitrobenzene with p-chlorophenol.
GB55818/68A 1967-12-01 1968-11-25 Preparation of salicylanilides derivatives Expired GB1212628A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US68712867A 1967-12-01 1967-12-01

Publications (1)

Publication Number Publication Date
GB1212628A true GB1212628A (en) 1970-11-18

Family

ID=24759178

Family Applications (1)

Application Number Title Priority Date Filing Date
GB55818/68A Expired GB1212628A (en) 1967-12-01 1968-11-25 Preparation of salicylanilides derivatives

Country Status (12)

Country Link
AT (1) AT293363B (en)
BR (1) BR6804469D0 (en)
CH (1) CH526514A (en)
CS (1) CS149651B2 (en)
DE (1) DE1810821A1 (en)
ES (1) ES360542A1 (en)
GB (1) GB1212628A (en)
IL (1) IL31105A (en)
NL (1) NL6816239A (en)
NO (1) NO122313B (en)
SE (1) SE368394B (en)
YU (1) YU32305B (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL184257C (en) * 1974-06-19 1989-06-01 Merck & Co Inc PROCESS FOR PREPARING RAFOXANIDE PREPARATIONS.

Also Published As

Publication number Publication date
IL31105A (en) 1972-08-30
ES360542A1 (en) 1970-10-16
IL31105A0 (en) 1969-01-29
AT293363B (en) 1971-10-11
YU32305B (en) 1974-08-31
CH526514A (en) 1972-08-15
CS149651B2 (en) 1973-07-25
NO122313B (en) 1971-06-14
YU276868A (en) 1974-02-28
NL6816239A (en) 1969-06-03
SE368394B (en) 1974-07-01
DE1810821A1 (en) 1969-07-17
BR6804469D0 (en) 1973-02-22

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PLNP Patent lapsed through nonpayment of renewal fees