GB1208541A - Benzodiazepine derivatives and a process for the manufacture thereof - Google Patents
Benzodiazepine derivatives and a process for the manufacture thereofInfo
- Publication number
- GB1208541A GB1208541A GB22780/69A GB2278069A GB1208541A GB 1208541 A GB1208541 A GB 1208541A GB 22780/69 A GB22780/69 A GB 22780/69A GB 2278069 A GB2278069 A GB 2278069A GB 1208541 A GB1208541 A GB 1208541A
- Authority
- GB
- United Kingdom
- Prior art keywords
- moiety
- haloalkanoyl
- alkanoyl
- halogen
- benzodiazepine derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 229940053197 benzodiazepine derivative antiepileptics Drugs 0.000 title abstract 2
- 125000003310 benzodiazepinyl group Chemical class N1N=C(C=CC2=C1C=CC=C2)* 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 3
- 239000002253 acid Substances 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 229910052736 halogen Inorganic materials 0.000 abstract 2
- 150000002367 halogens Chemical class 0.000 abstract 2
- 150000003839 salts Chemical class 0.000 abstract 2
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 abstract 1
- 101100516554 Caenorhabditis elegans nhr-5 gene Proteins 0.000 abstract 1
- KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 125000002252 acyl group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 125000000623 heterocyclic group Chemical group 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 125000004430 oxygen atom Chemical group O* 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 abstract 1
- 229940125723 sedative agent Drugs 0.000 abstract 1
- 239000000932 sedative agent Substances 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US72735668A | 1968-05-07 | 1968-05-07 | |
| US80670269A | 1969-03-12 | 1969-03-12 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| GB1208541A true GB1208541A (en) | 1970-10-14 |
Family
ID=27111492
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| GB22780/69A Expired GB1208541A (en) | 1968-05-07 | 1969-05-05 | Benzodiazepine derivatives and a process for the manufacture thereof |
Country Status (14)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7029918B2 (en) * | 2002-01-25 | 2006-04-18 | Roche Diagnostics Operations, Inc. | Water-soluble derivatives of lipophilic drugs |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT224121B (de) * | 1959-12-10 | 1962-11-12 | Hoffmann La Roche | Verfahren zur Herstellung von neuen 1,4-Benzodiazepin-Derivaten |
| AT256114B (de) * | 1964-08-13 | 1967-08-10 | Hoffmann La Roche | Verfahren zur Herstellung von neuen Benzodiazepinderivaten |
-
1969
- 1969-04-25 CH CH631569A patent/CH568996A5/xx not_active IP Right Cessation
- 1969-04-25 CH CH1581271A patent/CH579058A5/xx not_active IP Right Cessation
- 1969-04-25 CA CA049,759A patent/CA971170A/en not_active Expired
- 1969-04-25 CH CH1581371A patent/CH579059A5/xx not_active IP Right Cessation
- 1969-04-29 IL IL32100A patent/IL32100A/en unknown
- 1969-05-01 CA CA050,258,A patent/CA950455A/en not_active Expired
- 1969-05-05 GB GB22780/69A patent/GB1208541A/en not_active Expired
- 1969-05-06 NO NO1865/69A patent/NO123492B/no unknown
- 1969-05-06 DK DK247869AA patent/DK142456B/da not_active IP Right Cessation
- 1969-05-06 AT AT434369A patent/AT288403B/de not_active IP Right Cessation
- 1969-05-06 AT AT434469A patent/AT288404B/de not_active IP Right Cessation
- 1969-05-06 FR FR6914421A patent/FR2007970A1/fr not_active Withdrawn
- 1969-05-06 BE BE732558D patent/BE732558A/xx not_active IP Right Cessation
- 1969-05-07 JP JP44035117A patent/JPS4810479B1/ja active Pending
- 1969-05-07 SE SE06468/69A patent/SE351647B/xx unknown
- 1969-05-07 DE DE1923139A patent/DE1923139C2/de not_active Expired
- 1969-05-07 NL NL6906971.A patent/NL165176C/xx not_active IP Right Cessation
-
1971
- 1971-12-30 MY MY97/71A patent/MY7100097A/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BE732558A (enrdf_load_stackoverflow) | 1969-11-06 |
| CA971170A (en) | 1975-07-15 |
| SE351647B (enrdf_load_stackoverflow) | 1972-12-04 |
| DE1923139A1 (de) | 1969-11-20 |
| DE1923139C2 (de) | 1982-04-15 |
| AT288404B (de) | 1971-03-10 |
| CA950455A (en) | 1974-07-02 |
| CH579058A5 (enrdf_load_stackoverflow) | 1976-08-31 |
| JPS4810479B1 (enrdf_load_stackoverflow) | 1973-04-03 |
| NL165176B (nl) | 1980-10-15 |
| DK142456C (enrdf_load_stackoverflow) | 1981-08-03 |
| NL6906971A (enrdf_load_stackoverflow) | 1969-11-11 |
| IL32100A (en) | 1972-12-29 |
| IL32100A0 (en) | 1969-06-25 |
| CH568996A5 (enrdf_load_stackoverflow) | 1975-11-14 |
| AT288403B (de) | 1971-03-10 |
| DK142456B (da) | 1980-11-03 |
| MY7100097A (en) | 1971-12-31 |
| NL165176C (nl) | 1981-03-16 |
| NO123492B (enrdf_load_stackoverflow) | 1971-11-29 |
| FR2007970A1 (enrdf_load_stackoverflow) | 1970-01-16 |
| CH579059A5 (enrdf_load_stackoverflow) | 1976-08-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PS | Patent sealed [section 19, patents act 1949] | ||
| PCNP | Patent ceased through non-payment of renewal fee |