GB1208015A - Cephalosporins - Google Patents

Cephalosporins

Info

Publication number
GB1208015A
GB1208015A GB03868/67A GB1386867A GB1208015A GB 1208015 A GB1208015 A GB 1208015A GB 03868/67 A GB03868/67 A GB 03868/67A GB 1386867 A GB1386867 A GB 1386867A GB 1208015 A GB1208015 A GB 1208015A
Authority
GB
United Kingdom
Prior art keywords
acid
cephalosporins
group
amino
azidomethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
GB03868/67A
Other languages
English (en)
Inventor
Alan Gibson Long
Edward Mckenzie Wilson
William Graham
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Laboratories Ltd
Original Assignee
Glaxo Laboratories Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Laboratories Ltd filed Critical Glaxo Laboratories Ltd
Priority to GB03868/67A priority Critical patent/GB1208015A/en
Priority to US712963A priority patent/US3546219A/en
Priority to CH412068A priority patent/CH515275A/de
Priority to FR144494A priority patent/FR7573M/fr
Priority to FR1556823D priority patent/FR1556823A/fr
Priority to NL6804140A priority patent/NL6804140A/xx
Priority to SE03882/68A priority patent/SE360661B/xx
Priority to DE19681770033 priority patent/DE1770033A1/de
Publication of GB1208015A publication Critical patent/GB1208015A/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D501/14—Compounds having a nitrogen atom directly attached in position 7
    • C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
    • C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
    • C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
    • C07D501/38—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof
    • C07D501/44—Methylene radicals, substituted by nitrogen atoms; Lactams thereof with the 2-carboxyl group; Methylene radicals substituted by nitrogen-containing hetero rings attached by the ring nitrogen atom; Quaternary compounds thereof with the 7-amino radical acylated by an araliphatic carboxylic acid, which is substituted on the aliphatic radical by hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G75/00—Macromolecular compounds obtained by reactions forming a linkage containing sulfur with or without nitrogen, oxygen, or carbon in the main chain of the macromolecule

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Cephalosporin Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
GB03868/67A 1967-03-23 1967-03-23 Cephalosporins Expired GB1208015A (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
GB03868/67A GB1208015A (en) 1967-03-23 1967-03-23 Cephalosporins
US712963A US3546219A (en) 1967-03-23 1968-03-14 3-azidomethyl - 7-arylglyoxamidoceph-3-em-4-carboxylic acids and their salts and alpha-carbonyl derivatives
CH412068A CH515275A (de) 1967-03-23 1968-03-20 Verfahren zur Herstellung von Derivaten von Cephalosporin C
FR144494A FR7573M (enExample) 1967-03-23 1968-03-20
FR1556823D FR1556823A (enExample) 1967-03-23 1968-03-20
NL6804140A NL6804140A (enExample) 1967-03-23 1968-03-22
SE03882/68A SE360661B (enExample) 1967-03-23 1968-03-22
DE19681770033 DE1770033A1 (de) 1967-03-23 1968-03-22 Neue Derivate von Cephalosporin C und Verfahren zu ihrer Herstellung(II)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB03868/67A GB1208015A (en) 1967-03-23 1967-03-23 Cephalosporins

Publications (1)

Publication Number Publication Date
GB1208015A true GB1208015A (en) 1970-10-07

Family

ID=10030858

Family Applications (1)

Application Number Title Priority Date Filing Date
GB03868/67A Expired GB1208015A (en) 1967-03-23 1967-03-23 Cephalosporins

Country Status (7)

Country Link
US (1) US3546219A (enExample)
CH (1) CH515275A (enExample)
DE (1) DE1770033A1 (enExample)
FR (2) FR1556823A (enExample)
GB (1) GB1208015A (enExample)
NL (1) NL6804140A (enExample)
SE (1) SE360661B (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2223375A1 (de) * 1971-05-14 1972-11-23 Glaxo Lab Ltd Antibiotika und Verfahren zu ihrer Herstellung
JPS5248996B1 (enExample) * 1971-01-29 1977-12-14 Glaxo Lab Ltd
US4201779A (en) 1977-03-12 1980-05-06 Hoechst Aktiengesellschaft 7[(2-Amino-thiazol-4-yl)glyoxylamido]-cephem derivatives and processes for their preparation

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE36041B1 (en) * 1971-01-29 1976-08-04 Glaxo Lab Ltd Improvements in or relating to antibiotics
GB1389194A (en) * 1971-01-29 1975-04-03 Glaxo Lab Ltd Antibiotics
US4209616A (en) * 1971-01-29 1980-06-24 Glaxo Laboratories Limited Syn isomers of cephalosporins having α-hydroximino- or α-acyloxyiminoacylamido groups at position-7
US4017515A (en) * 1971-05-14 1977-04-12 Glaxo Laboratories Limited α-(Etherified oximino) carboxylic acids and acid chlorides
US3966717A (en) * 1971-05-14 1976-06-29 Glaxo Laboratories Limited 7-β-Acylamido-3-carbamoyloxymethylceph-3-em-4-carboxylic acids and salts thereof
US4024133A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(thienyl-,furyl- or pyridylacetamido)]cephalosporins
US4024137A (en) * 1971-05-14 1977-05-17 Glaxo Laboratories Limited 7β-[2-Etherified oximino-2-(phenyl- or naphthylacetamido)] cephalosporins
US3971778A (en) * 1972-05-12 1976-07-27 Glaxo Laboratories Limited Cephalosporins having (α-etherified oximino)acylamido groups at the 7-position
US3974153A (en) * 1971-05-14 1976-08-10 Glaxo Laboratories Limited 7-Hydrocarbonoxy imino-acetamido-3-carbamoyloxy methylceph-3-em-4 carboxylic acids
US3932385A (en) * 1971-05-14 1976-01-13 Glaxo Laboratories Limited Penicillins having a 6β-(α-etherified oximino) acylamido group
SU589918A3 (ru) * 1971-07-14 1978-01-25 Мерк Энд Ко Инк (Фирма) Способ получени сложного эфира 3-замещенной метил-7-ациломидо-7-метокси-2-цефем -4- карбоноаой кислоты
US3883518A (en) * 1972-05-15 1975-05-13 Merck & Co Inc 3-Methylene cephalosporins
GB1472534A (en) * 1973-07-06 1977-05-04 Glaxo Lab Ltd 7beta-hydroxyiminoacylamido-cephalosporins
US3931159A (en) * 1974-03-18 1976-01-06 American Home Products Corporation Substituted 3-benzoylacrylamido-cephalosporanic acid derivative
US4020058A (en) * 1974-10-03 1977-04-26 Glaxo Laboratories Limited Improvements in or relating to cephalosporin antibiotics
US4165430A (en) * 1976-03-19 1979-08-21 Glaxo Laboratories Limited Cephalosporins having a 7-carboxy substituted α-etherified oximinoarylacetamido) group
DE2818263A1 (de) * 1978-04-26 1979-11-08 Bayer Ag Beta-lactamantibiotika
IT1211080B (it) * 1981-07-21 1989-09-29 Craf Sud Idrazonocefem derivati biologicamente attivi.
GB8810393D0 (en) * 1988-05-03 1988-06-08 Glaxo Group Ltd Chemical process
SG146624A1 (en) * 2003-09-11 2008-10-30 Kemia Inc Cytokine inhibitors

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3338896A (en) * 1965-03-10 1967-08-29 Fujisawa Pharmaceutical Co 7-(substituted propionamido) cephalosporanic acid and derivatives thereof

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5248996B1 (enExample) * 1971-01-29 1977-12-14 Glaxo Lab Ltd
DE2223375A1 (de) * 1971-05-14 1972-11-23 Glaxo Lab Ltd Antibiotika und Verfahren zu ihrer Herstellung
DE2265234A1 (de) * 1971-05-14 1976-12-30 Glaxo Lab Ltd Zwischenprodukte fuer antibiotika und verfahren zu ihrer herstellung
JPS531280B1 (enExample) * 1971-05-14 1978-01-17
US4201779A (en) 1977-03-12 1980-05-06 Hoechst Aktiengesellschaft 7[(2-Amino-thiazol-4-yl)glyoxylamido]-cephem derivatives and processes for their preparation

Also Published As

Publication number Publication date
SE360661B (enExample) 1973-10-01
FR7573M (enExample) 1970-01-05
CH515275A (de) 1971-11-15
NL6804140A (enExample) 1968-09-24
DE1770033A1 (de) 1971-09-16
US3546219A (en) 1970-12-08
FR1556823A (enExample) 1969-02-07

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Legal Events

Date Code Title Description
PS Patent sealed [section 19, patents act 1949]
PCNP Patent ceased through non-payment of renewal fee